Clinical diagnosis of systemic lupus erythematosus

Armas-Cruz, R; Harnecker, J; Ducach, G; Jalil, J; Gonzalez, F

doi:10.1016/0002-9343(58)90080-9

Cited by 116 publications

(23 citation statements)

References 15 publications

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“…We therefore studied plasma renin activity (PRA) in patients with systemic lupus erythematosus (SLE) and found it elevated in a large percentage of them even in the presence of normal arterial blood pressure. This could be due to sodium wastage through damaged tubuli and correlate with the reported low prevalence of severe hypertension in lupus nephritis [2,7,15,16,23,27]. We report herein evidence to support this contention.…”

Section: Introductionsupporting

confidence: 88%

“…In this case, the previous biopsies had shown segmental glomerular sclerosis and slight interstitial changes. Finally, it is tempting to speculate that the presence of a salt-wasting tubular defect in lupus nephritis might be related to the rela tively low frequency of hypertension in SLE which in different series [2,15,16,23,27] of SLE patients varies from 8 to 25% and it is usually mild. Severe hypertension in SLE is usually associated with high corticosteroid doses or with renal insufficiency [15,40].…”

Section: Discussionmentioning

confidence: 99%

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Normotensive Hyperreninemia in Systemic Lupus erythematosus

Herrera-Acosta¹,

Guerrero²,

Erbessd³

et al. 1978

Nephron

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High plasma renin activity (PRA) was found in 16 of 42 randomly selected non-uremic systemic lupus erythematosus (SLE) patients. Mild hypertension was present in 3 of the 16. 6 high-PRA and 10 normal-PRA patients were admitted to a metabolic ward. Salt restriction produced a disproportionate rise in both PRA and aldosterone, adecrease in glomerular filtration rate (GFR), and a slightly greater negative sodium balance in the group with high PRA. Potassium excretion was less than intake in both groups. Balance studies were performed in 6 additional high-PRA patients before and during indomethacin administration (150 mg/24 h). PRA and aldosterone were markedly suppressed by indomethacin. U_NaV was significantly greater than in the control period despite of the 28% reduction in GFR. These results suggest that high PRA is secondary to impaired distal tubular sodium reabsorption. Such a defect could be responsible for the relatively low frequency of hypertension in lupus nephritis.

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Section: Introductionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Normotensive Hyperreninemia in Systemic Lupus erythematosus

Herrera-Acosta¹,

Guerrero²,

Erbessd³

et al. 1978

Nephron

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“…With our present 2 cases, a total of 36 cases will permit a meaningful review of SLE-myelopathy. 5 other cases have been mentioned, with little detail, among large surveys of SLE cases [Du bois, 1953;Armaz-Cruz et al, 1958;Bash and Vachtenheim, 1963;Nusonova and Konchakova. 1965;Sergenl et al, 1975], The results of the literature reviewed arc summa rized in table II. 32 of these 36 patients were female giving a female:male ratio of 8:1 which is approxi mately comparable to that in the literature [Siegal et al, 1965], Their ages ranged be tween 11 and 65 years with a mean of 34.5 years.…”

Section: Discussionmentioning

confidence: 99%

Myelopathy as the Main Presenting Feature of Systemic Lupus erythematosus

Al-Husaini¹,

Jamal²

1985

Eur Neurol

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Myelopathy is a rare complication of systemic lupus erythematosus (SLE). Only 34 cases have been fully described in the literature. 5 other cases have been listed among large surveys of SLE patients. It is particularly unusual to find evidence of spinal cord involvement as the presenting feature of the disease. 2 cases are described in which SLE presented as a myelopathy and both made a satisfactory recovery with steroid treatment. The literature concerning SLE-myelopathy is reviewed.

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“…Although neck rigidity was reported in classic studies of SLE (5,6), aseptic meningitis is one of the least common of the neurologic manifestations of the disease and a number of studies have not mentioned it as one of its complications (15)(16)(17)(18)(19)(20). Cerebrospinal fluid abnormalities suggestive of meningeal inflammation have frequently been described i n association with a variety of the neurologic syndromes associated with SLE.…”

Section: Discussionmentioning

confidence: 99%

Aseptic meningitis in systemic lupus erythematosus

Canoso

Cohen

1975

Arthritis & Rheumatism

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Three patients with aseptic meningitis were subsequently diagnosed as having lupus erythematosus. One patient had a single meningitic episode, another had chronic meningitis, and the third two acute episodes 5 years apart. All 3 patients developed further neuropsychiatric manifestations of SLE, leading to death in 1. Aseptic meningitis appears to be an early manifestation of SLE and may herald more serious brain damage. No new cases of aseptic meningitis occurred in this series after initiation of therapy for SLE. In contrast, bacterial meningitis did occur as a late complication of the disease. Address reprint orders to Dr. Cohen. Submitted for publication November 5, 1974; accepted January 20,1975. A l t h o u g h systemic lupus erythematosus (SLE) can involve any part of the c e n t r a l and peripheral nervous system (1-4), lupus m e n i n g i t i s has seldom been described (1-14). Because of t h e i m p o r t a n t differential diagnostic aspects of t h i s condition and its relevance to therapy, t h e a u t h o r s describe in this rep o r t 3 p a t i e n t s in whom aseptic meningitis was an early and p r o m i n e n t manifestation of SLE.

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Clinical diagnosis of systemic lupus erythematosus

Cited by 116 publications

References 15 publications

Normotensive Hyperreninemia in Systemic Lupus erythematosus

Normotensive Hyperreninemia in Systemic Lupus erythematosus

Myelopathy as the Main Presenting Feature of Systemic Lupus erythematosus

Aseptic meningitis in systemic lupus erythematosus

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