Clinical dosimetric impact of Acuros XB and analytical anisotropic algorithm (AAA) on real lung cancer treatment plans : review

Rana, Suresh

doi:10.14319/ijcto.0201.9

Cited by 41 publications

(26 citation statements)

References 36 publications

(83 reference statements)

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“…Dose differences may also vary depending on the photon beam energy used for calculations. [13,14,15] The results of this study, however, showed no clear dependency on the field size. Similarly, difference between the PBC and measurements did not show a clear trend when results at various points (P1, P2, P3, and P4) were compared with each other.…”

Section: Discussioncontrasting

confidence: 73%

Limitation of Pencil Beam Convolution (PBC) Algorithm for Photon Dose Calculations in Inhomogeneous Medium

Dorje¹

2014

JCTR

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Purpose: The main purpose of this study is to investigate the accuracy of pencil beam convolution (PBC) algorithm when high-density inhomogeneity is involved along the photon beam path. This study will help the PBC users understand the limitation of PBC during the treatment planning of real cancer treatment plans, especially when tumor is located beyond high-density tissue such as bone. Methods: Inhomogeneous phantom (30 cm x 30 cm, 17 cm deep) with a 5 cm thick solid water as the top layer followed by 5 cm thick PVC and 7 cm solid water was manufactured for depth dose calculations and measurements. Data were obtained beyond PVC medium for three field sizes: 5 x 5 cm 2 , 10 x 10 cm 2 , and 20 x 20 cm 2. Dose calculations were performed using PBC and measurements were done using chamber. Measured and calculated data were compared against each other. Results: PBC produced dose prediction errors beyond high density medium by 3.7% to 7.3% for field size 5 x 5 cm 2 , by 4.8% to 6.9% for field size 10 x 10 cm 2 , and by 5.9% to 7.3% for field size 20 x 20 cm 2. The results of this study, however, showed no clear dependency on the field size. Similarly, difference between the PBC and measurements did not show a clear trend when results at various points were compared with each other. Conclusion: PBC can overestimate the dose by up to 7.3% beyond high-density medium. High density materials such metallic immobilization devices must be avoided in the beam path during the patient treatment.

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Section: Discussioncontrasting

confidence: 73%

Limitation of Pencil Beam Convolution (PBC) Algorithm for Photon Dose Calculations in Inhomogeneous Medium

Dorje¹

2014

JCTR

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“…The AAA algorithm used in this study was proved to be better than the pencil beam convolution algorithm 18. However, it was expected that the calculation accuracy would further be improved if the Acuros XB algorithm19 was used.…”

Section: Discussionmentioning

confidence: 85%

Evaluation of the dosimetric impact of applying flattening filter‐free beams in intensity‐modulated radiotherapy for early‐stage upper thoracic carcinoma of oesophagus

Zhang

Lin

et al. 2015

J of Medical Radiation Sci

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IntroductionFlattening filter-free (FFF) radiation beams have recently become clinically available on modern linear accelerators in radiation therapy. This study aimed to evaluate the dosimetric impact of using FFF beams in intensity-modulated radiotherapy (IMRT) for early-stage upper thoracic oesophageal cancer.MethodsEleven patients with primary stage upper thoracic oesophageal cancer were recruited. For each patient, two IMRT plans were computed using conventional beams (Con-P) and FFF beams (FFF-P), respectively. Both plans employed a five-beam arrangement and were prescribed with 64 Gy to (planning target volume) PTV1 and 54 Gy to PTV2 in 32 fractions using 6 MV photons. The dose parameters of the target volumes and organs at risks (OARs), and treatment parameters including the monitor units (MU) and treatment time (TT) for Con-P and FFF-P were recorded and compared.ResultsThe mean D5 of PTV1 and PTV2 were higher in FFF-P than Con-P by 0.4 Gy and 0.3 Gy, respectively. For the OARs, all the dose parameters did not show significant difference between the two plans except the mean V5 and V10 of the lung in which the FFF-P was lower (46.7% vs. 47.3% and 39.1% vs. 39.6%, respectively). FFF-P required 54% more MU but 18.4% less irradiation time when compared to Con-P.ConclusionThe target volume and OARs dose distributions between the two plans were comparable. However, FFF-P was more effective in sparing the lung from low dose and reduced the mean TT compared with Con-P. Long-term clinical studies are suggested to evaluate the radiobiological effects of FFF beams.

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“…We have used analytic anisotropic algorithm (AAA) for dose calculations, which is a RTOG‐acceptable algorithm for dose computations for RTOG lung protocols. Several papers have pointed out the limitation of AAA in the presence of low‐density heterogeneity (21‐25) . Recently, a number of investigators have recommended the use of Acuros XB, a new dose calculation algorithm available in Eclipse, for dose calculations in lung treatment plans (21‐25) .…”

Section: Discussionmentioning

confidence: 99%

A dosimetric comparison of three‐dimensional conformal radiotherapy, volumetric‐modulated arc therapy, and dynamic conformal arc therapy in the treatment of non‐small cell lung cancer using stereotactic body radiotherapy

Rauschenbach

Mackowiak

Malhotra

2014

J Applied Clin Med Phys

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This study evaluates three‐dimensional conformal radiotherapy (3D CRT), volumetric‐ modulated arc therapy (VMAT), and dynamic conformal arc therapy (DCAT) planning techniques using dosimetric indices from Radiation Therapy Oncology Group (RTOG) protocols 0236, 0813, and 0915 for the treatment of early‐stage non‐small cell lung cancer (NSCLC) using stereotactic body radiotherapy (SBRT). Twenty‐five clinical patients, five per lung lobe, previously treated for NSCLC using 3D CRT SBRT under respective RTOG protocols were replanned with VMAT and DCAT techniques. All plans were compared using respective RTOG dosimetric indices. High‐ and low‐dose spillage improved for VMAT and DCAT plans, though only VMAT was able to improve dose to all organs at risk (OARs). DCAT was only able to provide a minimal improvement in dose to the heart and ipsilateral brachial plexus. Mean bilateral, contralateral, and V20 (percentage of bilateral lung receiving at least 20 Gy dose) doses were reduced with VMAT in comparison with respective 3D CRT clinical plans. Though some of the DCAT plans had values for the above indices slightly higher than their respective 3D CRT plans, they still were able to meet the RTOG constraints. VMAT and DCAT were able to offer improved skin dose by 1.1% and 11%, respectively. Monitor units required for treatment delivery increased with VMAT by 41%, but decreased with DCAT by 26%. VMAT and DCAT provided improved dose distributions to the PTV, but only VMAT was consistently superior in sparing dose to OARs in all the five lobes. DCAT should still remain an alternative to 3D CRT in facilities that do not have VMAT or intensity‐modulated radiotherapy (IMRT) capabilities.PACS numbers: 87.53.Ly, 87.55.dk, 87.55.D‐

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Clinical dosimetric impact of Acuros XB and analytical anisotropic algorithm (AAA) on real lung cancer treatment plans : review

Cited by 41 publications

References 36 publications

Limitation of Pencil Beam Convolution (PBC) Algorithm for Photon Dose Calculations in Inhomogeneous Medium

Limitation of Pencil Beam Convolution (PBC) Algorithm for Photon Dose Calculations in Inhomogeneous Medium

Evaluation of the dosimetric impact of applying flattening filter‐free beams in intensity‐modulated radiotherapy for early‐stage upper thoracic carcinoma of oesophagus

A dosimetric comparison of three‐dimensional conformal radiotherapy, volumetric‐modulated arc therapy, and dynamic conformal arc therapy in the treatment of non‐small cell lung cancer using stereotactic body radiotherapy

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