“…Encouraging minimal invasive dentistry ( Mm et al, 2014 ), mainly for dental caries treatment ( Thompson et al, 2008 , Bjørndal, 2018 ), has led to the development of conservative strategies ( McComb, 2000 , Pintado-Palomino et al, 2019 ) that involve the preservation of the affected dentin for lesion treatment ( Statement, 2017 ). In this regard, the development of bioactive restorative materials has become a necessity and it has been the subject of studies ( Abuna et al, 2016 , Amrollahi et al, 2016 , Braga, 2019 , Sauro and Pashley, 2016 ).…”