Clinical Effect of Lifestyle Modification on Cardiovascular Risk in Prehypertensives: PREHIPER I Study

Márquez-Celedonio, Félix Guillermo; Téxon-Fernández, Obdulia; Chávez-Negrete, Adolfo; Hernández-López, Sergio; Marín-Rendón, Sadoc; Berlín-Lascurain, Susana

doi:10.1016/s1885-5857(09)71518-x

Cited by 19 publications

(19 citation statements)

References 14 publications

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“…A similar result was observed in a smaller study recently carried out in a Mexican population sample. 9 A relevant issue that remains unexplored in the study by Fogari et al is whether the obtained results will be maintained in the long term, that is, whether the patients who maintain their normal weight will develop hypertension in the future. Even if these patients develop hypertension, they will have less exposure to hypertension as a risk factor and will require drug medication later in life compared with overweight individuals.…”

mentioning

confidence: 99%

Weight loss and blood pressure normalization: the relevance of early interventions in hypertension

Cicero

2010

Hypertens Res

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mentioning

confidence: 99%

Weight loss and blood pressure normalization: the relevance of early interventions in hypertension

Cicero

2010

Hypertens Res

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“…36,37 In contrast, maintained or increased cardiovascular fitness in younger adults can change cardiovascular risk trajectory. 16,38 However, a dominant finding is that we have not observed any sustained effects in blood pressure reduction from studies reporting outcomes after 12 months. This is the first review in the blood pressure literature to explore the sustained effects of exercise intervention and the first to exclude studies with <3 months follow-up, which may have previously contributed to overestimation of effect.…”

Section: Discussionmentioning

confidence: 83%

“…Additional analyses 16 Describe methods of additional analyses (e.g., sensitivity or subgroup analyses, meta-regression), if done, indicating which were pre-specified.…”

Section: -7 Supplementmentioning

confidence: 99%

Will Exercise Advice Be Sufficient for Treatment of Young Adults With Prehypertension and Hypertension? A Systematic Review and Meta-Analysis

et al. 2016

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Previous studies report benefits of exercise for blood pressure control in middle age and older adults, but longer-term effectiveness in younger adults is not well established. We performed a systematic review and meta-analysis of published randomized control trials with meta-regression of potential effect modifiers. An information specialist completed a comprehensive search of available data sources, including studies published up to June 2015. Authors applied strict inclusion and exclusion criteria to screen 9524 titles. Eligible studies recruited younger adults with a cardiovascular risk factor (with at least 25% of cohort aged 18–40 years); the intervention had a defined physical activity strategy and reported blood pressure as primary or secondary outcome. Meta-analysis included 14 studies randomizing 3614 participants, mean age 42.2±6.3 (SD) years. At 3 to 6 months, exercise was associated with a reduction in systolic blood pressure of −4.40 mm Hg (95% confidence interval, −5.78 to −3.01) and in diastolic blood pressure of −4.17 mm Hg (95% confidence interval, −5.42 to −2.93). Intervention effect was not significantly influenced by baseline blood pressure, body weight, or subsequent weight loss. Observed intervention effect was lost after 12 months of follow-up with no reported benefit over control, mean difference in systolic blood pressure −1.02 mm Hg (95% confidence interval, −2.34 to 0.29), and in diastolic blood pressure −0.91 mm Hg (95% confidence interval, −1.85 to 0.02). Current exercise guidance provided to reduce blood pressure in younger adults is unlikely to benefit long-term cardiovascular risk. There is need for continued research to improve age-specific strategies and recommendations for hypertension prevention and management in young adults.

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“…It is necessary to expand the scale of clinical trials in order to adopt appropriate interventions in the treatment of inflammatory mechanisms, to understand the development and outcome of intervention after PH, and to better monitor the occurrence and development of hypertension. Therefore, for effective control of hypertension and other cardiovascular and cerebrovascular diseases, more attention should be paid to the basis and clinical intervention of hs-CRP during the PH stage (Timmermans et al, 1993;Julius et al, 2006;Márquez-Celedonio et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Intervention for prehypertension and its cardiovascular risk factors in Inner Mongolia

Zhao¹,

Wang²,

Lü³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Blood pressure levels were evaluated among prehypertension patients with associated cardiovascular risk factors to determine the effect of different interventions with respect to new endpoint events. A total of 1112 patients were equally and randomly divided into control, lifestyle, drug, and lifestyle + drug groups, and were followed-up for 12 months. We collected the age, height, weight, blood pressure, heart rate, blood lipid levels, blood glucose levels, and other clinical data from all subjects at the baseline and at the end of the follow-up period. The average systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the intervention groups were significantly reduced after the intervention (lifestyle + drug > drug > lifestyle). SBP and DBP were higher in the control group than before intervention (P < 0.05). Age, gender, heart rate, triglyceride (TG) levels, body mass index (BMI), alcohol consumption, and family history were the major factors affecting blood pressure. Increased BMI, TG, high-sensitivity C-reactive protein, alcohol consumption, family history, SBP, and DBP were major risk factors of hypertension. At the end of the follow-up period, there were 67 cases of hypertension, 32 cases of diabetes, and 12 cases of the endpoint events. Hypertension and diabetes events were reduced in the intervention groups relative to the control group (P < 0.05). The number of cases with incident cardiovascular endpoints did not differ among the three intervention groups (P > 0.05). Therefore, hypertension and related cardiovascular events can be controlled with different interventions.

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Clinical Effect of Lifestyle Modification on Cardiovascular Risk in Prehypertensives: PREHIPER I Study

Cited by 19 publications

References 14 publications

Weight loss and blood pressure normalization: the relevance of early interventions in hypertension

Weight loss and blood pressure normalization: the relevance of early interventions in hypertension

Will Exercise Advice Be Sufficient for Treatment of Young Adults With Prehypertension and Hypertension? A Systematic Review and Meta-Analysis

Intervention for prehypertension and its cardiovascular risk factors in Inner Mongolia

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