Clinical effect of short-term spinal cord stimulation in the treatment of patients with primary brainstem hemorrhage-induced disorders of consciousness

Huang, Weilong; Chen, Qiang; Liu, Lin; Tang, Jiaxi; Zhang, Hua; Tang, Zongzhe; Jiang, Qing; Li, Tao; Jian-wu, Liu; Wang, Dong

doi:10.3389/fneur.2023.1124871

Cited by 4 publications

(1 citation statement)

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“…This modality of treatment demonstrates potential not only for transient cognitive improvements but also for facilitating long-term recovery in brain function ( Yang et al, 2022 ). Recently, percutaneous short-term SCS has been reported to may be useful in the treatment of DoC ( Yang et al, 2022 ; Huang et al, 2023 ). This minimally invasive approach affords clinicians the ability to directly engage with neuronal circuits that may be responsible for the modulation of conscious states ( Zhuang et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Anatomical-related factors and outcome of percutaneous short-term spinal cord stimulation electrode shift in patients with disorders of consciousness: a retrospective study

He,

Yang,

et al. 2024

Front. Aging Neurosci.

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BackgroundDisorders of consciousness (DoC) represent a spectrum of neurological conditions that pose significant treatment challenges. Percutaneous short-term spinal cord stimulation (SCS) has emerged as a promising experimental diagnostic treatment to assess and potentially improve consciousness levels. However, the effectiveness of this intervention is frequently compromised by the shift of electrodes, particularly in the cervical region, which can negatively affect therapeutic outcomes.MethodsThis retrospective study aimed to study if electrodes shift in percutaneous short-term SCS in patients with DoC would affect the outcome. We analyzed the relationship between electrode shift length and patient outcome, as well as the correlation with various anatomical parameters, including the actual length of the cervical spine, linear length, spinal canal transverse diameter, spinal canal diameter, and C2 cone height, in a cohort of patients undergoing the procedure.ResultsOur findings revealed that in patients with better outcome, there are significant less patient with electrode shift (p = 0.019). Further, a linear correlation was found between the length of electrode shift and patients’ outcome (Rho = 0.583, p = 0.002), with longer shift lengths associated with poorer outcomes. Contrary to our expectations, there was no significant association between the measured anatomical parameters and the extent of electrode shift. However, a trend was found between the actual length of the cervical spine and the shift of the electrode (p = 0.098). Notably, the shorter spinal canal transverse diameter was found to be significantly associated with better outcome in patients with DoC receiving percutaneous short-term SCS (p = 0.033).ConclusionThese results highlight the clinical importance of electrode stability in the cervical region during SCS treatment for patients with DoC. Ensuring secure placement of electrodes may play a crucial role in enhancing patients’ outcome and minimize postoperative complications. Given the lack of association with expected anatomical parameters, future research should investigate other factors that could impact electrode stability to optimize this therapeutic intervention.

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