Clinical effectiveness and cost-effectiveness of clopidogrel and modified-release dipyridamole in the secondary prevention of occlusive vascular events: a systematic review and economic evaluation

Abstract

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The effectiveness and cost-effectiveness of biomarkers for the prioritisation of patients awaiting coronary revascularisation: a systematic review and decision model

“…These estimates are based on previous work 201 which employed systematic approaches to identify appropriate utility estimates to apply to patients with ischaemic heart disease, myocardial infarction and stroke, representing the major health states of the model.…”

Modified-Release Dipyridamole Combined with Aspirin for Secondary Stroke Prevention

“…However, in light of the current evidence, some of the more recently issued recommendations suggest that MR-dipyridamole combined with aspirin may be preferable to aspirin monotherapy and possibly to clopidogrel monotherapy (e.g., ACCP 2004 [26]; National Institute for Health and Clinical Excellence 2005 [26]). One of the points in favor of the combination is its positive cost-benefit ratio for stroke prevention (at least for the first 2 years after stroke) [27].…”

Exploring Structural Uncertainty in Model-Based Economic Evaluations

“…inclusion/exclusion of non-vascular death as a health state. They found that model predictions were strongly sensitive to this structural assumption, with potential impact on funding decisions [17]. In another model commissioned by the NICE comparing alternative management strategies for lung cancer, the cost-effectiveness results were most sensitive to the choice of survival functions (Weibull vs. log-logistic) used to estimate overall survival [18].…”