Clinical effectiveness and cost-effectiveness of stem cell transplantation in the management of acute leukaemia: a systematic review

Abstract

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Costo efectividad de los tratamientos de consolidación para la leucemia mieloide aguda en pacientes pediátricos, estratificados en riesgo alto, dentro del sistema de salud colombiano

“…Los resultados no contradicen los de otros estudios de costo-efectividad en los que se ha evaluado el trasplante en la consolidación de leucemias agudas en población adulta (11,26,27) mediante árboles de decisión con condiciones agudas como resultado y las mismas distribuciones de probabilidad teóricas.…”

“…No existen modelos económicos que comparen el costo-efectividad del trasplante y de la quimioterapia en el tratamiento de la leucemia mieloide aguda en niños (11). Debido a las diferencias en la efectividad y el costo que las alternativas de tratamiento de consolidación para la leucemia mieloide aguda representan para el sistema de salud, es necesario evaluar su costo-efectividad.…”

Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation: a Global Observational Study

“…[17][18][19][20][21] The economic aspects of HSCT with its patient-centered approach have traditionally concentrated on costs of the individual procedure for an individual patient. 17,[22][23][24] Studies on macro-economic aspects or on cost-effectiveness in individual countries have gained broader acceptance only recently. 11,21,22,25 They were triggered in part by some rapid changes in the use of HSCT, such as for breast cancer or chronic myeloid leukemia 18,26 and by the rising awareness of the disturbing gap between unlimited requests and limited resources in any health care system.…”

Evidence-Based Guided Interventions in Acute Leukemia

“…Four systematic reviews evaluated the effect of autologous hematopoietic cell transplantation (HCT) in first CR (Ashfaq, et al 2010, Levi, et al 2004, Nathan, et al 2004, Wang, et al 2010.…”

“…Eight reviews and meta-analyses were identified but only three of them were systematic and comprehensive (Ashfaq, et al 2010, Hubel, et al 2011, Koreth, et al 2009. Koreth et al performed a systematic review comparing allogeneic HCT with conventional consolidation chemotherapy or autologous HCT (Koreth, et al 2009).…”