Clinical effectiveness of a silk fabric in the treatment of atopic dermatitis

Ricci, Giampaolo; Patrizi, Annalisa; Bendandi, Barbara; Menna, Giuseppe; Varotti, Elisa; Masi, Massimo

doi:10.1111/j.1365-2133.2004.05705.x

Cited by 93 publications

(71 citation statements)

References 12 publications

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“…Topical steroids and immunomodulators also appear to be able to reduce the degree of bacterial colonization [4,5,6], as does the recently proposed use of silver-coated textiles [7]. In a previous work with a special silk fabric (MICROAIR DermaSilk®) [8] we observed a clinical improvement of eczema in the area covered by the textile in 46 children with AD. This fabric also has antibacterial properties in vitro [9] thanks to a water-resistant treatment with AEGIS AEM 5572/5, a durable antimicrobial finish for textile products that prevents bacterial survival (including S. aureus ) and odour.…”

Section: Introductionmentioning

confidence: 93%

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Evaluation of the Antibacterial Activity of a Special Silk Textile in the Treatment of Atopic Dermatitis

Ricci¹,

Patrizi²,

Mandrioli³

et al. 2006

Dermatology

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Background: Increased skin Staphylococcus aureus colonization is frequently found in atopic patients. The reduction of local overinfection decreases skin inflammation and improves the flares. Objective: To evaluate the effectiveness of the antimicrobial activity of a silk fabric (MICROAIR DermaSilk®) coated with alkoxysilane quaternary ammonium with durable antimicrobial properties (AEGIS AEM 5572/5) in children affected by atopic dermatitis (AD). Methods: Sixteen children, 12 affected by AD with symmetric eczematous lesions on the antecubital areas and 4 without any cutaneous disease, used, for 7 days, tubular arm covers made of this special silk fabric but only one of each pair was coated with AEGIS AEM 5572/5. Microbiological examinations were done with standard cultural swabs and by means of quantification of bacterial agents using agar plates at baseline, after 1 h and after 7 days. Results: After 7 days a significant improvement in the mean value of the ‘local SCORAD’ index was observed in both the covered areas compared to the values obtained at baseline. The reduction in the mean number of colony forming units per square centimetre was similar in both areas. Conclusions: Although this special silk fabric seems to be able to improve skin lesions in AD, we were unable to demonstrate that such silk fabrics coated with AEGIS AEM 5572/5 have an antibacterial activity in vivo, as shown in vitro.

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Section: Introductionmentioning

confidence: 93%

“…In conclusion, the improvement seen in the eczema appears to be related to the direct contact with a delicate and soft fabric such as serine-free silk [8] which relieves itching, restores the disrupted cutaneous barrier and, thanks to the AEGIS coaction, protects the area from further overinfection.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antibacterial Activity of a Special Silk Textile in the Treatment of Atopic Dermatitis

Ricci¹,

Patrizi²,

Mandrioli³

et al. 2006

Dermatology

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“…It is hoped that future material innovations will further improve compliance with compression therapy (30,31).…”

Section: Prospectsmentioning

confidence: 99%

Contact allergy to compression stockings: Is this possible?

Valesky¹,

Kaufmann²,

Meißner³

2014

Phlebologie

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SummaryIn the treatment of chronic venous insufficiency or lymphoedema, compression stockings are standard therapy. Nevertheless, patient compliance is relatively low. One reason for this are symptoms such as itching, burning or redness, which are considered by patients, but also frequently by attending physicians, as an allergy to the compression stockings. The review covers the basics of contact allergies, shows how often allergies to compression stockings occur and what the causes are, and briefly describes the common differential diagnoses, their causes and prevention. Schlüsselwörter

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“…Such a commercially available fabric (DermaSilk®) has antibacterial properties thanks to treatment with AEGIS AEM 5772/5, a covalently linked water-resistant antimicrobial finish for textiles based on the compound alkoxysilane quaternary ammonium [17]. In a recent trial, patients wearing DermaSilk showed significant clinical improvement of AD when compared to patients wearing cotton clothes [5, 18]. The aim of our study was to compare the effectiveness of DermaSilk with that of standard care consisting of the application of a modern topical corticosteroid and the wearing of cotton clothes in children suffering from moderate AD.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Silk Clothing in the Treatment of Atopic Dermatitis Proves Comparable to Topical Corticosteroid Treatment

et al. 2006

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Background: Atopic dermatitis (AD) is aggravated by mechanical irritation and bacterial colonization. Objective: This study compared the efficacy of an antimicrobial silk fabric (DermaSilk®) with that of a topical corticosteroid in the treatment of AD. Methods: Fifteen children were enrolled and wore a dress, where the left side was made of DermaSilk and the right side was made of cotton. The right arm and leg were treated daily with the corticosteroid mometasone for 7 days. The treatment efficacy was measured with a modified EASI (Eczema Area and Severity Index) and with an assessment by the patients/parents and by a physician. All patients were evaluated at baseline, as well as 7 and 21 days after the initial examination. Results: All parameters showed that, irrespective of the treatment, there was a significant decrease of eczema after 7 days. No significant difference between DermaSilk-treated and corticosteroid-treated skin could be observed. Conclusion: DermaSilk showed potential to become an effective treatment of AD.

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Clinical effectiveness of a silk fabric in the treatment of atopic dermatitis

Abstract: The use of special silk clothes may be useful in the management of AD in children.

Cited by 93 publications

References 12 publications

Evaluation of the Antibacterial Activity of a Special Silk Textile in the Treatment of Atopic Dermatitis

Evaluation of the Antibacterial Activity of a Special Silk Textile in the Treatment of Atopic Dermatitis

Contact allergy to compression stockings: Is this possible?

Antimicrobial Silk Clothing in the Treatment of Atopic Dermatitis Proves Comparable to Topical Corticosteroid Treatment

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