Depression is common in older home health patients and increases their risk of adverse outcomes. Depression screening is required by Medicare’s OASIS. The Depression CAREPATH was developed as a feasible strategy for home health nurses to manage depression in their medical patients. The protocol builds on nurses’ existing clinical skills and is designed to fit within routine home visits. Major components include ongoing clinical assessment, care coordination, medication management, education and goal setting. In a randomized trial, Depression CAREPATH patients had greater improvement in depressive symptoms compared to usual care. The difference between groups was significant at three months, growing larger and more clinically meaningful over one year. The intervention had no impact on patient length-of-stay, number of home visits, or duration of visits. Thus, home health nurses can play a pivotal role in the long term course and outcomes of depressed patients.