Clinical effectiveness of late maxillary protraction in cleft lip and palate: A methods paper

Abstract

Objectives A prospective parallel cohort trial was conducted to compare outcomes of patients treated with maxillary protraction vs. LeFort 1 maxillary advancement surgery. Setting and Sample Population The primary site for the clinical trial is Children’s Hospital Los Angeles; the satellite test site is Seattle Children’s Hospital. All patients have isolated cleft lip and palate and a skeletal Class III malocclusion. Material & Methods A total of 50 patients, ages 11–14 will be recruited for the maxillary protraction cohort. The maxillary surgery cohort consists of 50 patients, ages 16–21, who will undergo LeFort 1 maxillary advancement surgery. Patients with additional medical or cognitive handicaps were excluded from the study. Results Current recruitment of patients is on track to complete the study within the proposed recruitment period. Conclusion This observational trial is collecting information that will examine dental, skeletal, financial, and quality of life issues from both research cohorts.

Reply: Thirty Years Later: What Has Craniofacial Distraction Osteogenesis Surgery Replaced?

“…We are optimistic that the results will demonstrate whether traction can substitute for distraction in select cases. 6…”

“…We are optimistic that the results will demonstrate whether traction can substitute for distraction in select cases. 6 Condylar changes with mandibular distraction, although recognized, remain poorly understood. Gu et al's observations reinforce how little we know about the effect of mechanical force on condylar morphology.…”

“…Because Dr. Ransom et al 6 have revealed that the new bone formed during mandibular distraction osteogenesis was derived from mandibular skeletal stem cells through Rainbow mice in 2018.…”