Clinical Effects of a Hop Water Extract on Japanese Cedar Pollinosis during the Pollen Season: A Double-Blind, Placebo-Controlled Trial

Segawa, Shuichi; Takata, Yoshinobu; Wakita, Yoshihisa; Kaneko, Toshihiro; Kaneda, Hirotaka; Watari, Junji; Enomoto, Tatsuko; Enomoto, Tadao

doi:10.1271/bbb.70157

Cited by 15 publications

(10 citation statements)

References 25 publications

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“…Nevertheless, flavonoid intervention in humans is limited. Previous clinical research using several flavonoid extracts indicates that flavonoids have therapeutic effects on allergic rhinitis [66,67,68,69,70]. These extracts were Perilla frutescens (rosmarinic acid as a major flavonoid), apple polyphenols (procyanidins or apple condensed tannin, catechin, epicatechin, phlorizin, and chlorogenic acid), hop water extract (quercetin and kaempferol glycosides), and tomato extract (naringenin chalcone).…”

Section: Effects Of Flavonoids On Allergic Diseasesmentioning

confidence: 99%

Potential Beneficial Effects of Wine Flavonoids on Allergic Diseases

et al. 2019

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Wine, a widely consumed beverage, comprises several biophenols that promote health. Flavonoids, majorly present in red wine, have been shown to have antioxidant, anti-inflammatory, anticancer, and immunomodulatory activities. Regular consumption of red wine (100 mL/day) is estimated to provide an average of 88 mg of flavonoids, whereas recent epidemiological studies indicate that wine is one of the major sources of flavonoid intake amongst wine lovers in European countries (providing an average intake of 291–374 mg/day of flavonoids). In addition to being antioxidants, in vitro studies suggest that flavonoids also have anti-allergic activities that inhibit IgE synthesis, activation of mast cells and basophils or other inflammatory cells, and production of inflammatory mediators, including cytokines. Furthermore, they affect the differentiation of naïve CD4+ T cells into effector T cell subsets. Moreover, several studies have reported the benefits of flavonoids in allergic models such as atopic dermatitis, asthma, anaphylaxis, and food allergy; however, evidence in humans is limited to allergic rhinitis and respiratory allergy. Although further evaluation is required, it is expected that an appropriate intake of flavonoids may be beneficial in preventing, and eventually managing, allergic diseases.

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Section: Effects Of Flavonoids On Allergic Diseasesmentioning

confidence: 99%

Potential Beneficial Effects of Wine Flavonoids on Allergic Diseases

et al. 2019

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“…Indeed, the results of recent clinical trials using flavonoid extracts or flavonoids indicate that flavonoids have beneficial effects on allergic rhinitis [104,105,106,107,108,109,110,111,112]. …”

Section: Human Intervention Studies Of Flavonoids In Asthmamentioning

confidence: 99%

Flavonoids and Asthma

Tanaka

Takahashi

2013

Nutrients

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Asthma is a chronic disease, characterized by airway inflammation, airflow limitation, hyper-reactivity and airway remodeling. It is believed that asthma is caused by the interaction between genetic and environmental factors. The prevalence of allergic diseases, including asthma, has increased worldwide during the past two decades. Although the precise reasons that have caused this increase remain unknown, dietary change is thought to be one of the environmental factors. Flavonoids, which are polyphenolic plant secondary metabolites ubiquitously present in vegetables, fruits and beverages, possess antioxidant and anti-allergic traits, as well as immune-modulating activities. Flavonoids are powerful antioxidants and anti-allergic nutrients that inhibit the release of chemical mediators, synthesis of Th2 type cytokines, such as interleukin (IL)-4 and IL-13, and CD40 ligand expression by high-affinity immunoglobulin E (IgE) receptor-expressing cells, such as mast cells and basophils. They also inhibit IL-4-induced signal transduction and affect the differentiation of naïve CD4+ T cells into effector T-cells through their inhibitory effect on the activation of the aryl hydrocarbon receptor. Various studies of flavonoids in asthmatic animal models have demonstrated their beneficial effects. The results of several epidemiological studies suggest that an increase in flavonoid intake is beneficial for asthma. Moreover, clinical trials of flavonoids have shown their ameliorative effects on symptoms related to asthma. However, these human studies are currently limited; further validation is required to clarify whether an appropriate intake of flavonoids may constitute dietary treatment and for part of a preventive strategy for asthma.

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“…Recently oral intake of extracts derived from tomato and hop water have been shown to be effective for perennial and seasonal allergic rhinitis [28, 29]. The main constituents in these extracts responsible for the antiallergic clinical effect are thought to be flavonoids such as narigenin, quercetin, and kaempferol, but it remains unknown what the direct effect of flavonoids by themselves is on symptoms of allergic rhinitis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Enzymatically Modified Isoquercitrin, a Flavonoid, on Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind Placebo-Controlled Trial

Kawai

Hirano

Arimitsu

et al. 2009

Int Arch Allergy Immunol

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Background: Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. Methods: In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two capsules daily of 100 mg EMIQ or a placebo for 8 weeks during the pollen season. Subjective symptoms and activities of daily living (ADL) scores were recorded every day, and the quality of life (QOL) score was obtained every 4 weeks. Blood sampling was performed before and after the study to measure serum cytokines, chemokines, IgE, quercetin and oxidized biomarkers. Results: During the entire study period, total ocular score and ocular itching score for the EMIQ group were significantly lower (p < 0.05) than for the placebo group. When limited to the individual periods, total symptom score for the EMIQ group was significantly lower (p < 0.05, week 4–5) than that for the placebo group while other scores for the EMIQ group, such as total nasal score (p = 0.06, week 4–5), nasal obstruction score (p = 0.08, week 4–5), lacrimation score (p = 0.06, week 5–6), ocular congestion score (p = 0.08, week 4–7) and ADL score (p = 0.08, week 4–7), all tended to be lower. The levels of serum cytokines such as interleukin (IL)-4, IL-5, IL-12, IL-13, interferon-γ, and eotaxin and IgE were not significantly downregulated by the intake of EMIQ but the serum concentrations of oxidized low-density lipoprotein and thymus and activation-regulated chemokine were reduced. Conclusion: Intake of the quercetin glycoside EMIQ was safe and influenced ocular symptoms caused by pollinosis.

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Clinical Effects of a Hop Water Extract on Japanese Cedar Pollinosis during the Pollen Season: A Double-Blind, Placebo-Controlled Trial

Cited by 15 publications

References 25 publications

Potential Beneficial Effects of Wine Flavonoids on Allergic Diseases

Potential Beneficial Effects of Wine Flavonoids on Allergic Diseases

Flavonoids and Asthma

Effect of Enzymatically Modified Isoquercitrin, a Flavonoid, on Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind Placebo-Controlled Trial

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