Clinical effects of an oral supplement rich in antioxidants on skin radiance in women

Abstract

BackgroundEnvironmental factors impact the skin aging resulting in decrease of skin radiance. Nutrition and particularly antioxidants could help to fight against skin degradation.ObjectiveThe aim of this study was to evaluate the effects of an oral supplement rich in specific antioxidants, SkinAx2TM, on the improvement of the skin radiance in women.MethodsThe open-label clinical study enrolled 35 women, aged 40–70, with facial dull complexion. Subjects were supplemented orally with a daily dosage of 150 mg of an antioxidant-rich formulation containing superoxide dismutase-rich melon concentrate, grape seed extract rich in monomers of flavanols, vitamin C, and zinc for 8 weeks. Each subject served as her own control. The C.L.B.T.™ test has been used to evaluate facial skin coloring (C), luminosity (L), brightness (B), and transparency (T) involved in skin radiance. Facial skin imperfections have been assessed by clinical assessment. Firmness has been evaluated by clinical assessment and cutometer measurement. Finally, an auto-questionnaire has been carried out in order to evaluate the satisfaction of the subjects concerning different parameters involved in skin radiance and the global efficacy of the supplement.ResultsSkin “red pink” and “olive” colors were significantly improved after supplementation (P<0.0001). Luminosity was increased by 25.9% (P<0.0001) whereas brightness and transparency were not affected by the supplementation. Facial skin imperfections were significantly reduced after the antioxidant-rich formulation intake (global reduction: −18.0%; P<0.0001). Indeed, dark circles, redness, and spots significantly diminished after oral treatment. Firmness and elasticity have been shown to be improved. Subjects were globally satisfied by the product (82.4%) and have found improvements on their facial skin. Furthermore, 64.7% reported to look better at the end of the supplementation.ConclusionThe oral supplement containing the antioxidant-rich formulation was found to improve skin radiance by reducing skin coloring, increasing face luminosity, reducing imperfections, and improving skin firmness in women with dull complexion.

An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants

“…Our results are in line with other studies which have also given a useful insight into the epidermal and dermal ultra-structural changes after either antioxidant topical application [56] or antioxidant oral supplementation [57][58][59] .…”

Prospective Evaluation of the Efficacy of a Food Supplement in Increasing Photoprotection and Improving Selective Markers Related to Skin Photo-Ageing

“…In both cases, the levels of MDA are increased as a result of the UVA exposure, but the per cent increase decreased over consecutive visits, indicating an effect of the food supplement in enhancing the antioxidant capacity of the skin. In comparison with other studies showing significant improvement of hydration, radiance, L*, ITA°a nd elasticity after 4-25 weeks of oral intake [49,50], in the present study a statistically significant improvement in these parameters was observed starting after 2 weeks of product use. The skin hydration results show that the food supplement quickly increased skin moisturisation levels, and was able to maintain higher skin hydration during the course of the study.…”

Effects of Topical Mandelic Acid Treatment on Facial Skin Viscoelasticity

“…More recent studies have used the Cutometer to examine the effects of botulinum toxin, various topical skin treatments and oral supplements. [9][10][11][12][13][14][15][16][17] Mandelic acid is a large α-hydroxy acid molecule, C 8 H 8 O 3 . Hydroxylation of amygdalin results in the production of mandelic acid.…”