Clinical effects of cervical conization with positive margins in cervical cancer

Abstract

Radical surgery after cervical conization is a common approach for the treatment of cervical cancer. In some cases, disease progression is observed after positive margins at conization, but the effect of conization on disease progression remains unclear. Thus, the aim of this study was to investigate the clinical outcomes of positive margins at conization in cervical cancer. A total of 101 patients who underwent cervical conization before radical hysterectomy and pelvic lymph node dissection were considered eligible by reviewing medical records. The association between the positive margins and patient outcomes, including subsequent lymph node metastasis, was evaluated. The rate of lymphovascular space invasion (LVSI) positivity at radical surgery was significantly higher in patients with positive margins (p = 0.017) than in those with negative margins, although there was no significant difference in the rate of pelvic lymph node metastasis (p = 0.155). Moreover, there was no significant difference in the overall survival or progression-free survival between the two groups (p = 0.332 and 0.200, respectively). A positive margin at conization presented no significant prognostic disadvantage; thus, diagnostic conization is one of the most suitable treatment options for early-stage cervical cancer that is difficult to accurately assess.

The Influence of Family-Oriented Enabling Psychological Nursing on Posttraumatic Stress and Fear of Recurrence in Patients with Cervical Cancer

“…Traumatic events were life events or disasters that threatened or seriously harmed life and physical integrity, such as the death of a loved one, accident, cancer, war, and natural disaster, which often damaged the physical and mental health of individuals [14]. Cervical cancer was one of the severe traumatic events that threatened the health and life of an individual, causing great damage not only to the individual's body but also to their psychological trauma [15]. e probability of posttraumatic stress disorder among people who had suffered major trauma was as high as 58% [16].…”

Extensive lesions and a positive cone margin are strong predictors of residual disease in subsequent hysterectomy following conization for squamous intraepithelial lesion grade 2 or 3 study design

“…Margin involvement is regarded as an important predictor of residual disease [ 5 , 14 , 26 ]. Repeated cervical conization is considered an acceptable alternative for women with a positive cone margin who desire fertility preservation, and hysterectomy is the definitive therapy for women with no reproductive requirements [ 27 , 28 ]. If the choice of treatment is new conization or hysterectomy, most women will unnecessarily undergo these procedures because they have no residual lesions.…”

“…Previous studies evaluated independent pre-conization variables and concluded that some pretreatment predictors might help in planning cervical conization [ 28 , 39 , 40 ]. In our study, logistic regression analysis revealed that involvement of the four quadrants was the only significant independent predictor of residual lesion.…”

Prognostic Value of Body Composition and Systemic Inflammatory Markers in Patients with Locally Advanced Cervical Cancer Following Chemoradiotherapy

“…10 Most previous studies on the prognosis of cervical cancer focused on tumour or treatment-related factors. 11,12 However, the prognostic implications of body composition remain unclear in patients with cervical cancer.…”