Clinical effects of dezocine plus propofol <i>vs</i> fentanyl plus propofol in painless colonoscopy

Yang, Yun Ho; Wang, Yajie; Liu, Hui; Deng, Shi-Kun; Zhang, Xifeng

doi:10.11569/wcjd.v22.i22.3340

Cited by 1 publication

(3 citation statements)

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“…The sample size varied from 60 to 200 patients with a total of 677. The 5 included studies involved gastroscopy, [ 29 ] colonoscopy, [ 23 , 30 ] and gastrointestinal endoscopy. [ 22 , 24 ] The combination of dezocine with propofol is compared with fentanyl and propofol in various doses.…”

Section: Resultsmentioning

confidence: 99%

“…[ 22 ] The rates of apnea, postoperative nausea, vomiting and dizziness were also found to be lower in dezocine supplementation group than those in fentanyl supplementation group. [ 23 ] However, another RCT revealed similar mean atrial pressure, heart rate, respiratory rate and SpO2 between two groups for gastrointestinal endoscopy. [ 24 ] Our meta-analysis suggested that dezocine plus propofol is associated with the significant reduction in propofol dose, awakening time and hypopnea compared to fentanyl plus propofol for gastrointestinal endoscopy, but comparable induction time, postoperative pain score, nausea, and vomiting are observed between 2 groups.…”

Section: Discussionmentioning

confidence: 99%

“…There are three reasons for explaining the significant heterogeneity. First, the 5 included studies involved gastroscopy, [ 29 ] colonoscopy, [ 23 , 30 ] and gastrointestinal endoscopy. [ 22 , 24 ] Different procedures and pain intensity are included in gastroscopy and colonoscopy.…”

Section: Discussionmentioning

confidence: 99%

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Analgesic comparison of dezocine plus propofol versus fentanyl plus propofol for gastrointestinal endoscopy

Zhang¹,

Zhao³

et al. 2021

Medicine

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Introduction: As the adjunctive anesthesia to propofol, both dezocine and fentanyl showed some potential for gastrointestinal endoscopy. This meta-analysis aimed to compare their efficacy and safety. Methods: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of dezocine versus fentanyl for the anesthesia of patients undergoing gastrointestinal endoscopy were included. Results: Five RCTs involving 677 patients were included in the meta-analysis. Overall, compared with fentanyl plus propofol for gastrointestinal endoscopy, dezocine plus propofol resulted in the reduction in propofol dose(mean difference [MD] = −11.72; 95% confidence interval [CI] = −22.83 to −0.61; P = .04), awakening time (std. MD = −1.79; 95% CI = −3.31 to −0.27; P = .02) and hypopnea (risk ratio [RR] = 0.16; 95% CI = 0.06–0.41; P = .0002), but had no remarkable effect on induction time (MD = 1.20; 95% CI = −0.98 to 3.39; P = .28), postoperative pain score (MD = −0.38; 95% CI = −1.00 to 0.24; P = .24), nausea or vomiting (RR = 0.45; 95% CI = 0.10–1.98; P = .29). Conclusion: Dezocine plus propofol may be better for the anesthesia of gastrointestinal endoscopy than fentanyl plus propofol.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%