Clinical Effects of Formulated Food of <i><scp>P</scp>eucedanum japonicum</i> Extract and Saw Palmetto Extract in Male Patients with Lower Urinary Tract Symptoms

Kageyama, Shinji; Beppu, Masanori; Ohnogi, Hiromu; Miyazaki, Shun; Haruno, Akihiro; Ito, Yoshihiko; Yamada, Shizuo

doi:10.1111/luts.12155

Cited by 6 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple studies have reported that oxidative stress increases in bladder tissues in diabetes (Changolkar et al 2005;Kanika et al 2011;Ha et al 2013;Chen et al 2015;Lin et al 2020;Wang et al 2021;Laddha and Kulkarni 2022). Oxidative stress has also been reported from clinical studies of various types of LUTD other than diabetes (Antunes-Lopes et al 2019;Matsuo et al 2020), and the urinary presence of oxidative stress indicators such as 8-hydroxy-2′doexyguanosine has been proposed as biomarker for LUTS in general (Kageyama et al 2018;Matsumoto et al 2019). Interestingly, treatment for 14 days with the antioxidants resveratrol (10 mg/kg/day, p.o.)…”

Section: Oxidative Stressmentioning

confidence: 98%

Established and emerging treatments for diabetes-associated lower urinary tract dysfunction

Erdogan

Liu

Arioglu‐Inan

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Dysfunction of the lower urinary tract (LUT) including urinary bladder and urethra (and prostate in men) is one of the most frequent complications of diabetes and can manifest as overactive bladder, underactive bladder, urinary incontinence, and as aggravated symptoms of benign prostate hyperplasia. We have performed a selective literature search to review existing evidence on efficacy of classic medications for the treatment of LUT dysfunction in diabetic patients and animals, i.e., α1-adrenoceptor and muscarinic receptor antagonists, β3-adrenoceptor agonists, and phosphodiesterase type 5 inhibitors. Generally, these agents appear to have comparable efficacy in patients and/or animals with and without diabetes. We also review effects of antidiabetic medications on LUT function. Such studies have largely been performed in animal models. In the streptozotocin-induced models of type 1 diabetes, insulin can prevent and reverse alterations of morphology, function, and gene expression patterns in bladder and prostate. Typical medications for the treatment of type 2 diabetes have been studied less often, and the reported findings are not yet sufficient to derive robust conclusions. Thereafter, we review animal studies with emerging medications perhaps targeting diabetes-associated LUT dysfunction. Data with myoinositol, daidzein, and with compounds that target oxidative stress, inflammation, Rac1, nerve growth factor, angiotensin II receptor, serotonin receptor, adenosine receptor, and soluble guanylyl cyclase are not conclusive yet, but some hold promise as potential treatments. Finally, we review nonpharmacological interventions in diabetic bladder dysfunction. These approaches are relatively new and give promising results in preclinical studies. In conclusion, the insulin data in rodent models of type 1 diabetes suggest that diabetes-associated LUT function can be mostly or partially reversed. However, we propose that considerable additional experimental and clinical studies are needed to target diabetes itself or pathophysiological changes induced by chronic hyperglycemia for the treatment of diabetic uropathy.

show abstract

Section: Oxidative Stressmentioning

confidence: 98%

Established and emerging treatments for diabetes-associated lower urinary tract dysfunction

Erdogan

Liu

Arioglu‐Inan

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

show abstract

“…47 SPE + Selenium + Lycopene in combination with tamsulosin is more efficacious than single therapies in improving IPSS and increasing maximal urinary flow-rate in patients affected by LUTS/BPH. Other combination therapies, such as with tamsulosin, [48][49][50] Urtica dioica, 39 Pinus pinaster 36 and Peucedanum japonicum, 51 have also shown positive results in co-prescriptions for treating BPH and BPH-linked disorders.…”

Section: Clinical Application Of Spe In Urinary System Diseasesmentioning

confidence: 99%

The Therapeutic Potential of Saw Palmetto Extract in Urological Disorders

Yin

Wang

et al. 2021

Natural Product Communications

View full text Add to dashboard Cite

Saw palmetto extract (SPE) has been widely used as a therapeutic remedy for urinary dysfunction in western countries. Furthermore, as an herb drug, it can be used as an alternative therapy for benign prostatic hyperplasia (BPH) due to its safety and minimum adverse effects. Reportedly, SPE improves the urinary symptoms, which mainly depend on anti-androgenic effects and effects on autonomic receptors in the lower urinary tract. However, the mechanisms of action responsible for the therapeutic roles of SPE have not been fully elucidated. Relevant studies indicate that SPE has some positive effects on the treatment of urological diseases in animals, and clinical trials are ongoing. In this review, we summarize the pharmacological properties and discuss the possible therapeutic mechanisms of SPE in urological diseases, including anti-androgenic effects, effects on autonomic receptors in the lower urinary tract, anti-inflammatory activity, anti-proliferative and pro-apoptotic effects, and highlight a potential therapeutic approach in the clinical treatment of patients with BPH, prostate cancer, chronic prostatitis (CP) and erectile dysfunction (ED).

show abstract

“…[ 139 ] 3. [ 74 ] Potentilla chinensis Rosaceae Chinese Cinquefoil Aerial part (aqueous extract) 1. Attenuated RA-induced DO in rats 2.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, clinical effects of the extract were investigated in male patients with LUTS. It improved urodynamic parameters and subjective symptom scores without reported adverse drug reactions [ 74 ]. These investigations suggest its possible therapeutic application in OAB treatment.…”

Section: Introductionmentioning

confidence: 99%

“…It has been used to treat diarrhoea and stomach ache, and served as a diuretic and sexual tonic [ 154 ]. Several clinical studies showed that administration of saw palmetto ( Serenoa repens ) extract improved the IPSS in patients with LUTS and alleviated urodynamic symptoms including urination frequency and nocturia [ 41 , 51 , 74 ]. In a clinical research encompassed 591 patients with inflammation assosciated chronic benign prostate conditions, saw palmetto extract (SPE) mitigated bladder voiding, LUTS as well as erectile function, and improved IPSS and National Institute of Health—Chronic Prostatitis Symptom Index (NIH-CPSI) [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Medicinal plants and natural products for treating overactive bladder

Chen,

Hoi,

Lee

2024

Chin Med

View full text Add to dashboard Cite

Background Overactive bladder (OAB) presents a high prevalence of 16–18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, medicinal plants and herbal remedies have been utilized for treating lower urinary tract symptoms (LUTS) in both Eastern and Western cultures since ancient times. In recent years, accumulating progress has also been made in OAB treatment research by using medicinal plants. Methods Relevant literature on the studies of medicinal plants and herbs used to treat OAB was reviewed. The medicinal plants were summarized and categorized into two groups, single-herb medications and herbal formulations. Results The present review has summarized current understanding of OAB’s pathophysiology, its available treatments and new drug targets. Medicinal plants and natural products which have been used or have shown potential for OAB treatment were updated and comprehensively categorized. Studies on a wide variety of medicinal plants showed promising results, although only a few phytochemicals have been isolated and identified. Until now, none of these herbal compounds have been further developed into clinical therapeutics for OAB. Conclusions This review provides the basis for discovering and designing new phytopharmaceutical candidates with effective and well-tolerated properties to treat OAB. Increasing evidences indicate new strategies with alternative herbal treatment for OAB have high efficacy and safety, showing great promise for their clinical use. Future studies in a rigorously designed controlled manner will be beneficial to further support the eligibility of herbal treatment as OAB therapeutics.

show abstract

Clinical Effects of Formulated Food of Peucedanum japonicum Extract and Saw Palmetto Extract in Male Patients with Lower Urinary Tract Symptoms

Abstract: Food formulated with P. japonicum extract and SPE may be useful to decrease frequency of nighttime urination and residual urine volume in male patients with LUTS.

Cited by 6 publications

References 14 publications

Established and emerging treatments for diabetes-associated lower urinary tract dysfunction

Established and emerging treatments for diabetes-associated lower urinary tract dysfunction

The Therapeutic Potential of Saw Palmetto Extract in Urological Disorders

Medicinal plants and natural products for treating overactive bladder

Contact Info

Product

Resources

About