Clinical effects of photodynamic and low-level laser therapies as an adjunct to scaling and root planing of chronic periodontitis: A split-mouth randomized controlled clinical trial

Malgikar, Suryakanth; Reddy, Srikanth; S, Sagar; Satyanarayana, D.; Reddy, Guntakala Vikram; Josephin, Johnson J

doi:10.4103/0970-9290.183130

Cited by 36 publications

(31 citation statements)

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“…This divergence of protocols also occurs with LLLT. Studies in humans have found promising results with a single LLLT session adjunct to SRP [23,24]; in turn Pjecic et al [25] found promising results with 10 LLLT sessions.…”

Section: Discussionmentioning

confidence: 99%

aPDT for periodontitis treatment in ovariectomized rats under systemic nicotine

Garcia

Júnior

Ervolino

et al. 2018

Photodiagnosis and Photodynamic Therapy

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Section: Discussionmentioning

confidence: 99%

aPDT for periodontitis treatment in ovariectomized rats under systemic nicotine

Garcia

Júnior

Ervolino

et al. 2018

Photodiagnosis and Photodynamic Therapy

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“…Differences of 0.10 mm and 0.19 mm were reported for the adjunctive application of soft lasers during SI (Aykol et al 2011, Lopes et al 2010. Luchesi et al (2013) and Malgikar et al (2016) reported a difference of 0.07 and 0.09 mm, respectively, between the improvements of PD after SI with or without adjunctive photodynamic therapy.…”

Section: Discussionmentioning

confidence: 95%

Adjunctive air-polishing with erythritol in nonsurgical periodontal therapy – a randomized clinical trial

Jentsch

Flechsig

Kette

et al. 2020

Preprint

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Background: This study was aimed to investigate if the adjunctive use of erythritol air-polishing powder applied with the nozzle-system during subgingival instrumentation (SI) has an effect on the outcome of non-surgical periodontal treatment in patients with moderate to severe periodontitis. Methods: Fourty-two individuals with periodontitis receiving nonsurgical periodontal therapy by SI without (controls, n=21) and with adjunctive air-polishing using nozzle + erythritol powder (test, n=21) were analyzed for clinical variables, four selected microorganisms and two biomarkers at baseline, before SI as well as three and six months after SI. Statistical analysis included nonparametric tests for intra- and intergroup comparisons. Results: In both groups, the clinical variables probing depth (PD), attachment level and BOP significantly improved three and six months after SI. The number of sites with PD ≥ 5 mm was significantly lower in the test group than in the control group after six months. At six months vs. baseline, there were significant reductions of Tannerella forsythia and Treponema denticola counts as well as lower levels of MMP-8 in the test group but not in the controls. There was no further significant difference of any clinical and non-clinical variable between both groups at three and six months after SI. Conclusions: Subgingival instrumentation with adjunctive erythritol air-polishing powder may add beneficial effects like reducing the probing depth measured as number of residual periodontal pocket with PD ≥ 5 mm when compared with subgingival instrumentation only. Clinical relevanceThe adjunctive use of erythritol air-polishing powder applied with the nozzle-system during SI may improve the clinical outcome of SI. Trial registration: The study was retrospectively registered in the German register of clinical trials, DRKS00015239 on 6th August 2018, https://www.drks.de/drks_web/navigate.do?navigationId =trial.HTML&TRIAL

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“…This is of great importance since the gram‐negative microorganisms analyzed here, Pg , Pi , and Fn , have shown great resistance against PDT compared with gram‐positive bacteria because of differences in the outer membrane structures of the two types of bacteria . While preserving the integrity of gingival tissue and preventing secondary gingival lesions this type of photosensitizing agent has also been shown to play an important role in preventing re‐colonization of specific periodontopathogens in periodontal lesions .…”

Section: Discussionmentioning

confidence: 97%

Impact of photodynamic therapy versus ultrasonic scaler on gingival health during treatment with orthodontic fixed appliances

et al. 2018

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Objectives: Poor oral hygiene during treatment with fixed appliances results in plaque accumulation. The presence of bacteria in the gingival crevice triggers an inflammatory reaction in the gingival tissues. The aim of this study was to compare the impact of two preventive treatments, photodynamic therapy (PDT), and ultrasonic scaler (US), on gingival health in patients under fixed orthodontic treatment. Methods: Twenty orthodontic patients were randomly allocated to two groups: PDT or US. Each group received seven sessions [days 0, 15, 30, 45, 90 (3months follow-up), 180 (6-months follow-up), 270 (9months follow-up)] of experimental interventions, and clinical parameters [Plaque index(PI); gingival index-(GI); probing depth(PD)], periodontopathogens [Agreggatibacter actinomycetemcomitans; Porphyromonas gingivalis; Prevotella intermedia; Micromonas micros; Fusobacterium nucleatum; Tannerella forsythia; Campylobacter rectus; Eikenella corrodens; Capnocytopaga sp.] and protein markers [IL-1b;IL-1ra;IL-6;IL-10;TNF-a;FGF-2/FGF basic] were monitored at baseline and at 3, 6, and 9 months. ANOVA, Student's t-test with Bonferroni correction and ANOVA with multiple rank test were used to identify differences between groups (P < 0.05). Results: Clinical assessments [PI, GI, and PD] yielded no differences (P > 0.05) between groups, which showed a major decrease at the start of the trial. Reductions in total colony forming units (log CFU reduction) were observed with both treatments, although to a greater extent in the PDT group, but with no differences between groups (P > 0.05). Similar reductions in log CFU counts of P. gingivalis, P. intermedia, and F. nucleatum were observed in both groups (P > 0.05). The two groups also showed similar trends for inflammatory mediators with decreased levels of IL-1b, IL-10, and TNF-a, whereas IL-6 and IL-1ra levels remained stable and those of FGF-2 were increased after both interventions, with no differences (P > 0.05) between groups. Conclusion: Both PDT and US methods proved similar effectiveness for the treatment of gingival inflammation induced by fixed orthodontic appliances. Lasers Surg. Med. 51:256-267, 2019.

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Clinical effects of photodynamic and low-level laser therapies as an adjunct to scaling and root planing of chronic periodontitis: A split-mouth randomized controlled clinical trial

Abstract: In patients with chronic periodontitis, a combination of a single application of PDT (using a 980 nm laser and MB) and LLLT provide additional benefit to SRP in terms of clinical parameters 6 months following the intervention.

Cited by 36 publications

References 0 publications

aPDT for periodontitis treatment in ovariectomized rats under systemic nicotine

aPDT for periodontitis treatment in ovariectomized rats under systemic nicotine

Adjunctive air-polishing with erythritol in nonsurgical periodontal therapy – a randomized clinical trial

Impact of photodynamic therapy versus ultrasonic scaler on gingival health during treatment with orthodontic fixed appliances

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