2020
DOI: 10.21203/rs.3.rs-90880/v1
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Clinical Effects of Polymyxin B in Patients infected with Carbapenem-resistant organisms

Abstract: Purpose: Carbapenem-resistant organisms (CROs) pose great challenges for clinical treatment. Polymyxin B (PMB) is one of the “last resort” choices of CRO infections. We explored the possible factors affecting PMB efficacy. Methods: This retrospective study involved CRO infected patients treated with PMB for ≥72 h. The endpoint indicator was clinical efficacy. We compared the characteristics (demographics, pathogenic bacteria, PMB treatment) between patients who had “clinical success” (CS) and “clinical failure… Show more

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“…We aimed to select targets with connection to known FBXW7 functions and to cover different degron strengths. ETS translocation variant 5 (ETV5) is a member of PEA3 subfamily of transcription factors, involved in cell growth, invasion and migration [222].…”
Section: Examine the Novel Motifs In Their Full-length Natural Contextmentioning
confidence: 99%
“…We aimed to select targets with connection to known FBXW7 functions and to cover different degron strengths. ETS translocation variant 5 (ETV5) is a member of PEA3 subfamily of transcription factors, involved in cell growth, invasion and migration [222].…”
Section: Examine the Novel Motifs In Their Full-length Natural Contextmentioning
confidence: 99%