Clinical Effects of Xinmailong Therapy in Patients with Chronic Heart Failure

Abstract

In the last 100 years, intensive studies have been done on the identification of the systematic approaches to find the cure for the chronic heart failure, however the mystery remains unresolved due to its complicated pathogenesis and ineffective early diagnosis. The present investigation was aimed to evaluate the potential effects of the traditional chinese medicine, Xinmailong, on the chronic heart failure (CHF) patients as compared to the standard western medical treatment available so far. In our study, we selected two groups of voluntary CHF patients at the Xiangya Hospital, which were allowed to administrate Xinmailong or standard treatments, respectively. Another group of voluntary healthy individuals were recruited as the control group. The treatment effectiveness was measured by five symptomatic factors, i.e. angiotensin II (Ang_II), high sensitivity C-reactive protein (hs_CRP), Left Ventricular End Systolic Volume Index (LVESVI), left ventricular ejection fraction (LVEF) and pro-B-type natriuretic peptide (NT_proBNP), between the control group and the CHF patients at different stages of drug administration and in different treatment groups. The timeline for the full dose administration was set to 15 days and five measurements as indicated above were taken on every 0, 7th and 15th day of the drug administration respectively. In the conducted study, similar symptomatic measurements were observed on day 0 in both treatment groups, and slight improvements were observed on 7th day. It was observed that after a full course of drug administration for 15 days, both of the treatment groups achieved statistically significant improvements in all the five measures, but Xinmailong was found to be more (almost double) statistically significant as compared with the available drug treatments for chronic heart failure.

Vasoconstrictive effect of <i>Xinmailong</i> injection in rat aorta

“…Our results are in consistent with the findings of clinical study which showed XML greatly improved the left ventricular ejection fractions in patients with chronic heart failure (Ma et al, 2013). Currently, it is widely recognized that the force of muscle contraction generated in heart mostly depends on the Ca 2+ influx as well as the release of Ca 2+ from sarcoplasmic reticulum.…”

“…We presume that the counterbalance between the XML-induced elevation of PGI 2 level and the XML-produced vasoconstriction keeps the maintenance of SBP. This finding provides another possible interpretation why XML is considered as a "safe drug" to treat the heart failure (Ma et al, 2013).…”

Predicting therapeutic response in patients with heart failure: the story of C-reactive protein

“…Other nontraditional therapies and supplements have been studied in several randomized studies in patients with chronic HF [47][48][49][50][51][52]. However, despite CRP-lowering effects, a correlation between clinical outcomes and CRP could not be established.…”

Normalizing Electrocardiograms of Both Healthy Persons and Cardiovascular Disease Patients for Biometric Authentication

“…dynamic heart rate variation, and acts as the diagnostic basis of various cardiovascular diseases (CVDs), e.g. arrhythmia [11], [12]. So it is becoming one of the major new features for the biometric authentication problem [1], [6], [9], [10], [13].…”