Clinical Efficacy and Cost-Benefit Analysis of Nocturnal Home Oxygen Therapy in Patients With Central Sleep Apnea Caused by Chronic Heart Failure

Improvement of Quality of Life With Nocturnal Oxygen Therapy in Heart Failure Patients With Central Sleep Apnea

“…Accordingly, cost savings of 51% were achieved, even including the cost of using the oxygen concentrator. 33 Although there were no differences in the overall event rates between the HOT and control groups in the present study, the lack of statistical significance for this comparison may reflect low study power rather than a lack of difference in the event rate between the groups. This is attributed to the small sample size and the greater proportion of patients with more severe HF (NYHA functional class III, 10 vs 5) and the smaller proportion of less severe HF patients (NYHA functional class II, 16 vs 20) in the treatment arm as compared with the control group, though this difference was not statistically significant.…”

Obstructive Sleep Apnea and Cardiovascular Disease

“…68,69 Previous reports described clinical benefits of bi-level positive airway pressure, home oxygen therapy and adaptive servoventilation for heart failure patients with CSA. [70][71][72] …”

Treatment Options for Cheyne-Stokes Respiration and Heart Failure

“…A subsequent questionnaire survey regarding the morbid events in those who continued HOT more than 6 months completed by physicians who participated in this study demonstrated that frequencies of hospitalization and emergency visit per year were reduced by 25%. Accordingly, cost savings, even including the cost for the use of the oxygen concentrator, were achieved by 51% [21]. Then, we continued to assess the effects of a prolonged use of nasal nocturnal oxygen and confirmed the sustained benefits observed in the short-term study [22].…”