Clinical efficacy and immune regulation with peanut oral immunotherapy

Jones, Stacie M.; Pons, Laurent; Roberts, Joseph L.; Scurlock, Amy M.; Perry, Tamara T.; Kulis, Mike; Shreffler, Wayne G.; Steele, Pamela H.; Henry, Karen A.; Adair, Margaret; Francis, James; Durham, Stephen R.; Vickery, Brian P.; Zhong, Xiao‐Ping; Burks, A. Wesley

doi:10.1016/j.jaci.2009.05.022

Cited by 626 publications

(693 citation statements)

References 39 publications

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“…Oral SIT possesses a high potential for the development of novel treatment modalities. In fact such approaches including oral immunotherapy for food allergy are under development [89][90][91][92][93].…”

Section: Clinical Usementioning

confidence: 99%

Mechanisms of allergen-specific immunotherapy

Akdiş

2011

Journal of Allergy and Clinical Immunology

461

264

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Section: Clinical Usementioning

confidence: 99%

Mechanisms of allergen-specific immunotherapy

Akdiş

2011

Journal of Allergy and Clinical Immunology

461

264

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“…In addition, the IgG4 antibodies to aeroallergens can produce a decrease in the processing and presenting activity of the APCs (DCs and B cells) thereby inhibiting the binding of allergen-IgE complexes to CD23 (van Neerven et al 1999;Wachholz et al 2003). In a similar way, in patients with peanut allergy the IgE-facilitated allergen binding assay has noted the possibility that these sIgG4 antibodies have a functional role in the inhibition of CD23-medited presentation by B cells to T cells (Jones et al 2009). …”

Section: Mechanisms Of Oit In Food Allergymentioning

confidence: 99%

Food Allergy and the Oral Immunotherapy Approach

Cabrera

Urra

2014

Arch. Immunol. Ther. Exp.

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Food allergy represents an increasing health problem, with children being the most affected population. The symptoms can appear within minutes or hours of ingesting the offending food, producing skin manifestations, respiratory, gastrointestinal and anaphylactic reactions in the severe forms. Food allergy is established by the loss of tolerance to food proteins, and is characterized by an altered balance of regulatory T (Treg) cells and the shift to Th2 type cytokines in the intestinal lamina propria. We have described the contribution of different factors in establishing oral tolerance, such as the antigenic exposition route, the gut microenvironment, and the timing of the food introduction. Apart from avoiding the food, immunotherapy is the only intervention which produces oral desensitization to food proteins. Among the underlying immunological mechanisms of oral immunotherapy (OIT) are the changes in humoral immunity (a decrease of allergen-specific IgE and an increase of allergen-specific IgG4) and cellular changes such as the increased number of FoxP3 ? Treg cells. At present, the experiences of OIT with various foods are offering promising results. OIT appears to be safe producing low adverse reactions, and effective in inducing desensitization in most subjects with food allergy.

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“…Three full-text articles and three abstracts relating to a total of six studies satisfied our inclusion criteria and were therefore included in this review (see the PRISMA flow diagram in Figure 1 and Table 1). [29][30][31][32][33][34] We also found several ongoing studies that had not yet reported on any of the outcomes of interest ( Table 2).…”

Section: Resultsmentioning

confidence: 90%