Clinical Efficacy and Patient Satisfaction with U-500 Insulin Pump Therapy in Patients with Type 2 Diabetes

Bulchandani, Deepti; Konrady, Tara; Hamburg, Mitchell S.

doi:10.4158/ep.13.7.721

Cited by 38 publications

(41 citation statements)

References 19 publications

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“…Administration of U-500 insulin via multiple daily injections showed an increase or no significant change in weight. Conversely, one study using continuous infusion administration revealed a 24.3% decrease in weight [22]. Overall, both methods of administration of U-500 insulin are effective.…”

Section: Choice Of Methods Of U-500 Insulin Deliverymentioning

confidence: 81%

“…Each study showed a statistically significant decrease in HbA 1c with an average of 2.02% across the studies. Three of the four studies demonstrated no significant change in total daily insulin dose, whereas the other study reported a decrease in total daily insulin doses [22]. The effect of U-500 insulin given via infusion on weight is unclear at this time with [22], no change [23], and weight gain all reported [9, 24••].…”

Section: U-500 Use By Continuous Subcutaneous Insulin Infusionmentioning

confidence: 96%

“…Bulchandani et al [22] performed a patient satisfaction survey regarding U-500 insulin use via pump delivery, and patients were asked to rate their satisfaction with insulin pump therapy compared with conventional insulin therapy, blood glucose control, and concern about side effects of insulin pump. The majority of patients reported higher satisfaction with U-500 insulin pump compared with conventional insulin therapy [22]. Similarly, Lane et al [23,24••] also found significantly greater satisfaction with the U-500 insulin use via pump.…”

Section: Patient Satisfaction With U-500 Insulin Usementioning

confidence: 99%

See 2 more Smart Citations

Extreme Insulin Resistance: Indications and Approaches to the Use of U-500 Insulin in Type 2 Diabetes Mellitus

Dailey

Tannock

2010

Curr Diab Rep

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The use of U-500 insulin in the management of highly insulin resistant diabetic patients is growing. There are a number of reports that have noted the effects of U-500 insulin using multiple daily injections or continuous subcutaneous insulin infusion on hemoglobin A(1c), weight, and total daily insulin dosage. The effect of U-500 insulin use on glycemic control, changes in body weight, total daily insulin dosage, incidence of hypoglycemia, and effect on lipid levels and blood pressure as well as patient satisfaction and quality of life will be reviewed. In addition, this article will delineate algorithms of U-500 use, compare multiple daily injections or continuous subcutaneous insulin infusion, and discuss U-500 insulin pharmacokinetics.

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Section: Choice Of Methods Of U-500 Insulin Deliverymentioning

confidence: 81%

Section: U-500 Use By Continuous Subcutaneous Insulin Infusionmentioning

confidence: 96%

Section: Patient Satisfaction With U-500 Insulin Usementioning

confidence: 99%

See 1 more Smart Citation

Extreme Insulin Resistance: Indications and Approaches to the Use of U-500 Insulin in Type 2 Diabetes Mellitus

Dailey

Tannock

2010

Curr Diab Rep

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“…U-500 dose rates and ratios may be converted either by dividing or multiplying by 5 for continuous subcutaneous insulin infusion (CSII). [13][14][15] U-500 in insulin pumps has been evaluated in small retrospective studies and one prospective study, as well as a few case reports. [13][14][15][16] …”

Section: Concentrated Insulin For Insulin Pumpmentioning

confidence: 99%

Clinical use of Humulin R U-500 insulin in the UK: results of the first Association of British Clinical Diabetologists’ U-500 audit

et al. 2016

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Human soluble insulin Humulin R U-500 has been in use worldwide for marked insulin resistance but is not specifically licensed in the UK. The Association of British Clinical Diabetologists conducted a nationwide audit of Humulin R U-500 to understand its use in the UK. The results show that 67 out of 119 clinicians who responded to the survey are using U-500R. The commonest indication for using it was a high daily insulin dose. These results are the first glimpse of the practical usage of high strength insulin in the UK and may help our approach to patients with high insulin resistance and the use of newly available higher concentration insulins. Br J Diabetes 2016;16:185-187

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“…Humulin U-500R dose rates and ratios may be converted by either dividing or multiplying by 5 for CSII. [44][45][46] Newer products may not be available in vials to avoid the dose conversion necessity. BIOD-531, which demonstrates similar activity with the exception of faster onset of action compared with Humulin U-500R, is also a potential insulin which may be useful in pumps.…”

Section: Concentrated Insulin For Insulin Pumpsmentioning

confidence: 99%

Insulin U100, 200, 300 or 500?

Dashora

Castro

2016

Br J Diabetes

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This article reviews the currently available information about insulin preparations in a concentration higher than 100 units/mL. These might be particularly useful in people with significant insulin resistance and high insulin requirement. U-200 insulin has low variability and lower (nocturnal) or similar risk of hypoglycaemia compared with U-100 insulin but is currently more expensive. U-300 glargine insulin has low variability, less weight gain and lower nocturnal hypoglycaemia in some studies in comparison to U-100 glargine. It is priced lower than U-100 glargine. U-500R insulin has been in use for some time worldwide but is not licensed in the UK. It also has low variability and lower cost per unit of insulin compared with U-100R. There is no specific delivery device and it has a higher risk of hypoglycaemia and weight gain. More insulins are in development (U-500 short-acting analogue [Fluorolog] and U-400 pre-mix like insulin BIOD-531, amongst others). Br J Diabetes 2016;16:10-15

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Clinical Efficacy and Patient Satisfaction with U-500 Insulin Pump Therapy in Patients with Type 2 Diabetes

Cited by 38 publications

References 19 publications

Extreme Insulin Resistance: Indications and Approaches to the Use of U-500 Insulin in Type 2 Diabetes Mellitus

Extreme Insulin Resistance: Indications and Approaches to the Use of U-500 Insulin in Type 2 Diabetes Mellitus

Clinical use of Humulin R U-500 insulin in the UK: results of the first Association of British Clinical Diabetologists’ U-500 audit

Insulin U100, 200, 300 or 500?

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