Clinical efficacy and safety of trimonthly administration of goserelin acetate 10.8 mg in premenopausal Chinese females with symptomatic adenomyosis: a prospective cohort study

Sun, Hao; Yuan, Man; Wang, Xinyu; Xue, Jie; Pan, Zangyu; Li, Hua; Yang, Linqing; Wang, Liming; Zhang, Shihong; Ren, Qianhui; Yan, Shumin; Liu, Dong; Zhang, Xinmei; Wang, Guoyun

doi:10.1080/09513590.2022.2160435

Cited by 1 publication

(1 citation statement)

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“…Sun et al [ 45 ] compared the efficacy and safety of goserelin, either by monthly or trimonthly administration, in 139 women with symptomatic adenomyosis. Women were included if they had dysmenorrhea and/or menorrhagia and had been diagnosed with adenomyosis by ultrasound.…”

Section: Resultsmentioning

confidence: 99%

Adenomyosis and Abnormal Uterine Bleeding: Review of the Evidence

Habiba,

Guo,

Benagiano

2024

Biomolecules

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Background: Thomas Cullen described bleeding abnormalities and dysmenorrhea as the “expected” presentations of adenomyomas. Adenomyosis is included within the FIGO classification of structural causes of abnormal uterine bleeding (AUB). Nevertheless, this long-standing association has been questioned by some authors who reported a high incidence of adenomyosis in uteri removed for indications other than AUB or dysmenorrhea. Here, we examine evidence for the link between adenomyosis and AUB. Methods: A comprehensive Medline literature review of all publications to October 2023. Results: Sixty-three articles were identified and included in the review. Despite a large body of studies, the available literature does not provide conclusive evidence of a link between adenomyosis and AUB. This is because of unsuitable study design, or poor characterization of the study population or of the inclusion or exclusion criteria. Additional challenges arise because of the lack of agreed criteria for diagnosing adenomyosis and the often absence of detailed assessment of menstrual blood loss. Adenomyosis often coexists with other conditions that have also been linked to similar symptoms, and many cases of adenomyosis are asymptomatic. Conclusion: Most of the existing literature and studies that addressed treatment outcome of adenomyosis started from the premise that a link between the condition and AUB had been proven. Yet, published information shows that aspects such a relationship is still uncertain. Further research is needed to address the relation between AUB and adenomyosis burden (or subtypes), distribution, and concomitant pathology.

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Section: Resultsmentioning

confidence: 99%