Clinical efficacy and safety of Ganshuang granules as an adjuvant treatment for chronic hepatitis B liver fibrosis: A protocol for systematic review and meta analysis

Traditional Chinese Medicine Ganshuang Granules Attenuate CCl4‐Induced Hepatic Fibrosis by Modulating Gut Microbiota

“…GS is a compound preparation of Chinese herbs and has been widely used for the treatment of liver diseases, including acute/chronic hepatitis and liver cirrhosis. [15] At present, there was limited evidence about its effects on hepatic fibrosis. Here, our results demonstrated the therapeutic value of GS in regressing hepatic fibrosis in CCl 4 -induced models.…”

“…GS is a compound preparation of Chinese herbs and has been widely used for the treatment of liver diseases, including acute/chronic hepatitis and liver cirrhosis [15] . At present, there was limited evidence about its effects on hepatic fibrosis.…”

“…Ganshuang granules (GS) is a commercial prepared prescription TCM and has been widely used in the treatment of chronic liver diseases. [15,16] However, its antifibrotic activity and underlying molecular mechanism remain poorly defined, particularly regarding the gut microbiota homeostasis. A better understanding of the relationship between GS and gut microbiota might form the basis for novel therapies.…”

“…In this context, the gut microbiota has emerged as an important frontier to understand the mechanism of TCM. Ganshuang granules (GS) is a commercial prepared prescription TCM and has been widely used in the treatment of chronic liver diseases [15,16] . However, its antifibrotic activity and underlying molecular mechanism remain poorly defined, particularly regarding the gut microbiota homeostasis.…”