Clinical efficacy and safety of nano‐microneedle‐assisted phenylethyl resorcinol for the treatment of infraorbital dark circles

Yu, Cheng-Qian; Xu, Xue‐Gang; Chen, Hong‐Duo; Li, Yuanhong

doi:10.1111/jocd.13641

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…Utilizing this method, drug penetration can be increased by up to 10 or 20 times. 11,12,18 However, it should be noted that the rate of "local irritation from medication" of group A was higher than that of group B, which might be related to the application of nano-microneedles.…”

Section: Discussionmentioning

confidence: 90%

“…Nano-microneedle technology has emerged in recent years to promote the penetration of drugs into the skin. 11,12 It has the advantages of safety, convenience, rapidity, and painlessness, which had been used in clinical practice. This study will review and report the clinical application effects and adverse reactions of the three methods: introduction of timolol maleate with nano-microneedles, application of timolol maleate, and oral propranolol.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and Safety of Introduction Timolol Maleate by Manometer Microneedles among Infantile Hemangioma: A Retrospective Study in China

Yuan

Wang

2023

Eur J Pediatr Surg

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Objective The objective of the study was to compare the effective rate, cure rate, adverse reaction rate, and effective time of three methods in the treatment of infantile hemangioma, hoping to provide reference for improving the clinical therapeutic effect. Methods This is a retrospective study of 307 infantile hemangioma patients admitted to the Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, from January 2014 to October 2021. The patients were divided into three groups. In group A, timolol maleate solution was introduced by the nano-microneedle technique (97 cases); in group B, timolol maleate drops dipped in medical swabs were applied (107 cases); and group C patients took propranolol orally (103 cases). The effective rate, cure rate, adverse reaction rate, and effective time of treatment were recorded and compared. Results The total effective rate, total cure rate, and total adverse reaction rate of the three groups were 87.6, 65.2, and 9.4%, respectively. The results showed that the effective and cure rates of group A were higher than those of group B (92.8 and 76.3%, respectively; p < 0.05), the adverse reaction rate of group C was higher than that of group B (17.5%, p < 0.05), and the effective time of group A was shorter than that of groups B and C. In most patients, symptoms significantly improved within 2 months (p < 0.05). Conclusion Timolol maleate introduced by nanometer microneedles is an effective and safe treatment for superficial hemangioma in infants with the highest effective and cure rates, lower incidence of adverse reactions, and the shortest effective treatment time.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Introduction Timolol Maleate by Manometer Microneedles among Infantile Hemangioma: A Retrospective Study in China

Yuan

Wang

2023

Eur J Pediatr Surg

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“…The diameter of each needle is only 80 nm, which is almost noninvasive. Utilizing this method, drug penetration can be increased by up to 10 or 20 times [11,12,18]. However, it should be noted that the rate of "Local irritation from medication" of Group NM was higher than Group MS, which might be related to the application of nano-microneedles.…”

Section: Discussionmentioning

confidence: 99%

“…It can be used for the delivery of drugs and other substances between cells because of their small diameter. The study found that the nano-microneedles can exert their effects while minimizing the damage to the intracellular environment [11,12]. The nano-microneedle has the advantages of safety, convenience, rapidity, and painlessness which had been used in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Delivery Timolol Maleate via Nanometer Microneedles among Superficial Infantile Hemangioma: a retrospective study in China

Yuan

Wang

et al. 2022

Preprint

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Background: Infantile hemangioma is common and affects multidemensionally. Drug therapy is a commonly used method in clinical practice, but its effect needs to be improved. The main challenge derives from the drug penetration and safety. The emergence of nanometer microneedle technology seems to solve these problems. The proposed study aims to review the efficacy and safety of the nano-microneedle by comparing with other drug therapy methods.Methods: A retrospective study reviewed patients with infantile hemangioma who were admitted to a tertiary stomatological hospital from January 2014 to October 2021. The cases were divided into three groups according to the different drugs and the different methods of drug administration, namely timolol maleate solution introduced by nanometer microneedle technology (NM), timolol maleate drops dipped with a medical swab (MS), and propranolol orally (PO). The effective rate, the cure rate, the rate of adverse reactions, and the time for treatment to be effective were recorded and compared.Results：A total of 307 cases were reviewed in the study (NM=97, MS=107, PO=103). The total effective rate, total cure rate, total rate of adverse reactions were 87.6%, 65.2%, 9.4%, respectively. There was statistically significant difference in the effective rate, the cure rate, the rate of adverse reactions, the time for treatment to be effective between the three groups. The results of the pairwise comparison showed that the effective rate of NM was higher than that of MS (P＜0.05), the cure rate of NM was higher than that of MS (P＜0.05), the rate of adverse reactions of OP was higher than that of MS (P＜0.05), the time for treatment to be effective of NM was shorter than that of MS and OP (P＜0.05).Conclusions: Our study revealed that delivery timolol maleate via nanometer microneedle is an efficacy and safety in infantile with superficial hemangioma. It has the highest effective rate and cure rate, lower incidence of adverse reactions, and shortest time for treatment to be effective.

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“…Neither invasive nor non-invasive therapies can provide effective treatment yet; consequently, the satisfaction and cure of patients are not satisfied. Therefore, new approaches and finding new medications for IOD are appreciated [7,8]. Traditional medicines and natural products have been proposed as possible sources of novel pharmaceuticals [9,10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Artemisia Absinthium L. Eye-Cream on Infra-Orbital Dark Circle: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Zargaran,

Hamdi,

Shirbeigi

et al. 2023

GMJ

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Background: The relative darkening of the lower eyelid skin, often linked with dark circles, may make one seem tired and older than the actual age. Considering the recommendations in the sources of Persian medicine regarding Artemisia absinthium L., this clinical trial aimed to investigate the effectiveness of cream prepared from the aqueous extraction of A.absinthium for infra-orbital dark circles removal.Materials and Methods: In this double-blind controlled clinical trial, an eye cream is made with 20% of the aqueous extract of A.absinthium in the base of the cream. For standardization based on Artemisinin, the high-performance liquid chromatography (HPLC) method was used. In two drug and placebo groups, 60 patients were equally enrolled in the trial. Erythema and pigmentation were evaluated via MexameterÂ®. Results: The cream was standardized, including 1.29Â±0.02 Âµg/mg Artemisinin in the product. Finally, 21 and 24 patients in the drug and placebo groups completed the study, respectively. In these groups, the difference in the mean Â± standard deviation (SD) delta erythema (DE), delta luminance (DL), erythema, and melanin factors before and after the research were significant (P<0.05). However, the rate of reduction of DE, Erythema, and Melanin and the rise of DL are more significant in the treatment group than in the placebo group. Furthermore, the mean values of DE and DL factors before the research were significantly different in the two groups (P<0.001), but after the investigation did not show a significant difference. The mean value of the Erythema factor in the two groups before (P=0.25) and after (P=0.5) did not show a significant difference. The mean value of Melanin after the research between the two groups showed a significant difference (P=0.01). Conclusion: The results show that the cream prepared from the herbal composition of Persian medicine improves the infra orbital dark circle around the eyes.[GMJ.2023;12:e2413]

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Clinical efficacy and safety of nano‐microneedle‐assisted phenylethyl resorcinol for the treatment of infraorbital dark circles

Cited by 5 publications

References 12 publications

Efficacy and Safety of Introduction Timolol Maleate by Manometer Microneedles among Infantile Hemangioma: A Retrospective Study in China

Efficacy and Safety of Introduction Timolol Maleate by Manometer Microneedles among Infantile Hemangioma: A Retrospective Study in China

Efficacy and Safety of Delivery Timolol Maleate via Nanometer Microneedles among Superficial Infantile Hemangioma: a retrospective study in China

Evaluation of the Effect of Artemisia Absinthium L. Eye-Cream on Infra-Orbital Dark Circle: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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