Clinical efficacy and safety of a once‐daily formulation of carbimazole in cats with hyperthyroidism

Frénais, R.; Rosenberg, Dan; Burgaud, S.; Horspool, L. J. I.

doi:10.1111/j.1748-5827.2009.00772.x

Cited by 26 publications

(23 citation statements)

References 13 publications

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“…In New Zealand, the use of carbimazole to treat cats with hyperthyroidism is off‐label, as the drug is not registered for veterinary use. In Europe, a once daily long‐acting carbimazole tablet (Vidalta) has been registered for veterinary use, and the FDA recently approved methimazole for the treatment of cats with hyperthyroidism in the United States …”

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confidence: 99%

The Efficacy and Safety of a Novel Lipophilic Formulation of Methimazole for the Once Daily Transdermal Treatment of Cats with Hyperthyroidism

Hill

Gieseg

Kingsbury

et al. 2011

Veterinary Internal Medicne

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Background: Previous studies on transdermal methimazole have used pluronic lecithin organogel as the vehicle. This might not be the most suitable vehicle for a lipophilic drug, such as methimazole.Hypothesis/Objectives: Once daily transdermal administration of a novel lipophilic formulation of methimazole is as safe and effective as oral carbimazole in treating hyperthyroidism in cats.Animals: Forty-five client-owned cats diagnosed with hyperthyroidism. Methods: Prospective study. Cats with newly diagnosed, untreated hyperthyroidism were treated with carbimazole (5 mg PO, q12h) or methimazole (10 mg) applied to the inner pinnae q24h. Cats were examined after 0, 1, 4, 8, and 12 weeks of treatment. Clinical signs, body weight, systolic blood pressure, hematologic, serum biochemical and urine parameters, total serum thyroxine concentrations (TT4), and serum methimazole concentrations were recorded.Results: No significant differences between groups were detected at day 0. Both formulations were effective in treating hyperthyroidism. No significant differences were detected in thyroxine concentrations, body weight, blood pressure, heart rate, alkaline phosphatase, alanine aminotransferase, creatinine, urea, and urine specific gravity (USG) between groups. The serum methimazole concentrations correlated poorly with TT4-concentrations in both groups.Conclusions and Clinical Importance: In this 12-week trial, once daily application of a novel formulation of transdermal methimazole applied to the pinnae was as effective and safe as twice daily oral carbimazole in the treatment of cats with hyperthyroidism. This novel formulation and transdermal application could have practical advantages to some pet owners.

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confidence: 99%

The Efficacy and Safety of a Novel Lipophilic Formulation of Methimazole for the Once Daily Transdermal Treatment of Cats with Hyperthyroidism

Hill

Gieseg

Kingsbury

et al. 2011

Veterinary Internal Medicne

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“…), 12 (Trepanier ) or 24 hours (Frenais et al . ), or can be applied as a transdermal gel (Buijtels et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…, Frenais et al . ). Carbimazole is the prodrug of thiamazole (methimazole) and is commonly used to treat feline hyperthyroidism.…”

Section: Introductionmentioning

confidence: 97%

Carbimazole‐associated hypersensitivity vasculitis in a cat

Bowlt

Cattin

Stewart

2013

J of Small Animal Practice

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Feline hyperthyroidism can be treated medically, surgically or with radioactive iodine. Carbimazole inhibits both triiodothyronine and thyroxine synthesis in the thyroid gland and reported side effects include mild eosinophilia, leucopenia and lymphocytosis, thrombocytopenia, elevated liver enzyme activities, gastrointestinal signs and skin abnormalities. This case report describes a cat with carbimazole-associated apparent hypersensitivity vasculitis causing digital and tail necrosis, with multiple renal infarcts. Withdrawal of carbimazole resulted in stable disease.

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“…The lower range is preferred initially and dose escalation can be made, based on total thyroxine blood concentration measurement. A sustained release formulation of carbimazole also exists that is efficient when given once daily (Frenais et al, 2009). Even though vomiting and anorexia are less commonly observed than methimazole, there are no studies comparing the adverse reactions of the two drugs.…”

Section: Carbimazolementioning

confidence: 99%

Feline hyperthyroidism: diagnosis and treatment

Kasabalis

Soubasis

Petanides

2017

J Hellenic Vet Med Soc

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Hyperthyroidism is a common endocrinopathy in cats older than 8 years, with no sex or breed predisposition. Benign adenomas and adenomatous hyperplasia of the thyroid gland is observed in the majority of cases. Symptoms reflect the effect of thyroid hormone excess in various systems, with weight loss, polyphagia, polyuria-polydipsia, cardiovascular and gastrointestinal abnormalities being common clinical manifestations. On clinical examination, there is frequently prominent thyroid enlargement. Common laboratory abnormal findings include increased activity of alkaline phosphatase and alanino-aminotransferase, hyperphosphataemia, azotaemia and decreased concentration of ionized calcium and creatinine. Definite diagnosis of the disease is based on the demonstration of increased blood concentration of thyroid hormones.Measurement of thyroxine concentration, alone or in conjunction with concentration of free thyroxine, is usually sufficient to reach a diagnosis. When diagnosis is uncertain, thyroid stimulating hormone, scintigraphy and dynamic function tests can be used. The possibility of concurrent diseases (e.g., renal failure, diabetes mellitus) must be investigated, as their presence has implications on diagnosis and treatment. Medical therapy, thyroidectomy, radionine therapy and low iodine diet are also valid options for treatment. Each has advantages and disadvantages that a clinician must take into consideration before instigating treatment. Prognosis for hyperthyroidism is favourable if no severe disease exists concurrently.

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Clinical efficacy and safety of a once‐daily formulation of carbimazole in cats with hyperthyroidism

Abstract: Once daily administration of controlled-release carbimazole tablets was effective and had expected tolerance in hyperthyroid cats during short- and long-term treatment.

Cited by 26 publications

References 13 publications

The Efficacy and Safety of a Novel Lipophilic Formulation of Methimazole for the Once Daily Transdermal Treatment of Cats with Hyperthyroidism

The Efficacy and Safety of a Novel Lipophilic Formulation of Methimazole for the Once Daily Transdermal Treatment of Cats with Hyperthyroidism

Carbimazole‐associated hypersensitivity vasculitis in a cat

Feline hyperthyroidism: diagnosis and treatment

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