Clinical efficacy and safety of NSCLC ancillary treatment with compound Kushen injection through immunocompetence regulation: A systematic review and meta-analysis

Wang, Dan; Shan, Jinjun; Huang, Tongxing; Peng, Wenpan; Zhu, Dongwei; Zhou, Xianmei; Wu, Qi

doi:10.1016/j.phymed.2022.154315

Cited by 6 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ingredients of S. flavescens include alkaloids, flavonoids, triterpenoids, and lignans [6,7]. Although the mechanism of activities was not clarified, it is believed that alkaloids and flavonoids are the bioactive component [8]. The typical alkaloids are the quinolizindine alkaloids such as matrine, sophocarpine, oxymatrine, sophoridine, sophorine, and oxysophocarpine.…”

Section: Introductionmentioning

confidence: 99%

Screening of Alkaloids in Sophora Flavescens with Liquid Chromatography Tandem Data-Dependent Acquisition Mass Spectrometry

Wang,

Ding

2023

J. Pharm. Res. Int.

View full text Add to dashboard Cite

A novel and simple hyphenated method was applied for the screening of alkaloids in S. flavescens. The approach combined easy sample extraction with an ultra-high-performance liquid chromatography (UPLC) and a high-resolution mass spectrometry (HRMS) in the data-dependent acquisition (DDA) method. With the optimized chromatographic program, ten alkaloids were screened. Among them, matrine, oxymatrine, oxysophoridine, sophocarpine, and oxysophocarpine were identified and quantified. The other five alkaloids were identified with accurate m/z value in MS1 and product ions in MS2. The quantification method was validated with specificity, linearity, recovery, and precision. The LOD and LOQ were determined. In twelve batches of collected S. flavescens roots, the identified ten alkaloids were all observed. The oxymatrine was the most abundant component, and sophocarpine was the least abundant in these samples. This comprehensive method is a powerful tool for the biochemical and clinical research of S. flavescens. It can also be adopted in resource utilization and related medicine quality control.

show abstract

Section: Introductionmentioning

confidence: 99%