Clinical Efficacy and Safety of<i>Navayasa Churna</i>in the Management of Iron Deficiency Anemia

Sk, Sharma; Sharma, Bhagwan Sahai; Rajesh, S.; Singh, Harbans; Sharma, Omraj; Meena, BR; Kumavat, VB

doi:10.5005/jp-journals-10064-0012

Cited by 7 publications

(3 citation statements)

References 68 publications

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“…These phytoactives also chelate Fe1 153,154 and might help to reduce gut dysbiosis that can result from the unabsorbed Fe. Several clinical studies conducted on Fe preparations used in Ayurveda to treat Pandu (IDA) have shown encouraging results without exhibiting the common side effects as seen with conventional modern Fe preparations [143][144][145][146][147][148][154][155][156][157][158][159][160][161][162][163] .…”

Section: Fig 5: Typical Process Of Bhasma Preparationmentioning

confidence: 99%

Untitled

2022

IJPSR

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Iron deficiency anaemia afflicts a large proportion of the human population, compromising productivity and quality of life. Iron supplements are widely prescribed for treating anaemia. However, poor compliance due to side effects, particularly gastrointestinal side effects, remain a hurdle in alleviating the problem, leading to unabated high prevalence. Thus, a fresh look at novel approaches to supplementation is essential. Iron toxicity is attributed to the Fenton Reaction and generation of reactive oxygen species leading to oxidative stress. Several studies suggest that the FR and ROS caused by excess iron, results in chronic inflammation, leading to metabolic syndrome, diabetes mellitus, atherosclerosis, cancer, neurodegenerative disorders. Iron chelates have been developed as treatment modalities to reduce free radical generation, reduce GI side effects, and enhance absorption. Classical Fe chelators, developed to counteract iron overload/ toxicity, cannot be used in IDA, due to severe side effects. In Ayurveda, iron formulations are prepared using phytomolecules that chelate iron and/or reduce OS. These phytomolecules are metabolized by the gut microbiota, which plays an important role in oxidative stress, release of inflammatory cytokines and GI side effects. The antioxidant, anti-inflammatory and antimicrobial actions of bio-active phytomolecules of Ayurvedic plants highlight their potential for reducing possible oxidant damage and side effects associated with iron supplementation. The present communication summarises the role of reactive oxygen species, potential of oxidant damage in causing side effects and microbial dysbiosis due to iron. Management of ‗Pandu' an anaemia -like condition described in Ayurveda and use of selected medicinal phytoactives are reviewed.

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Section: Fig 5: Typical Process Of Bhasma Preparationmentioning

confidence: 99%

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2022

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“…[ 17 18 ] The evidence on the safety and efficacy of many Ayurvedic interventions is available in the public domain. [ 19 20 21 22 ]…”

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confidence: 99%

Dhatri Lauha in the management of iron deficiency anemia

Rai

Srikanth²,

Rao³

et al. 2021

AYU (An International Quarterly Journal of Research in Ayurveda)

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Background: The burden of iron-deficiency anemia (IDA) remains persistently high in India due to the poor tolerability of oral iron supplementation. Therefore, more focus is required to explore traditional medicine for safe and effective options for managing IDA. Aim: To assess the clinical safety and efficacy of Dhatri Lauha in patients with IDA. Materials and methods: An open-label, prospective, single-arm, multi-center trial was conducted at 12 centers with a sample size of 40 participants per study site. Patients with IDA aged 18-60 years with hemoglobin levels in the range of 6-10gm/dl, mean corpuscular volume (MCV) <80 fl, mean corpuscular hemoglobin concentration (MCHC) <34 μg/dl, serum ferritin <30 μg/dl and serum iron <50 μg/dl were included in the study. Dhatri Lauha 500 mg capsule was administered twice daily with lukewarm water after meals for 45 days. The primary outcome measure was the change in hemoglobin (Hb%) level from baseline to day 45. Secondary outcome measures included the change in MCV, MCHC, serum iron and ferritin levels, incidence of adverse events, and change in safety parameters (liver and kidney function tests). The mean (statistical) change in outcome measures from baseline to day 45 was compared using a paired sample t-test. Results: Out of 458 participants enrolled in the study, 400 contributed to the final analysis. A significant difference was observed in the outcome parameters such as Hb%, MCV, MCHC, serum ferritin, and serum iron levels ( P < 0.001) after 45 days of treatment. Mean Hb% changed from 8.46 ± 1.14 g/dl at baseline to 9.18 ± 1.61 g/dl on day 45 ( P < 0.001). LFT and KFT were within the normal limits after the study period. No participant withdrew from the study due to adverse events. Conclusions: Dhatri Lauha is a safe intervention and can be expected to improve hemoglobin levels, red blood cell parameters, and iron stores in patients with IDA. Future RCTs with a larger sample size, standard care as control and a longer follow-up may produce more accurate and reliable results.

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“…While going through these drugs, properties such as Rasa, Guna, Virya, Vipaka and specific actions like Dipana, Pacana, Rasayana, Grahi as similar with Panduhara drugs which are mentioned in Bhavaprakasha Nighantu.Further clinical efficacy of these formulations has been scientifically proven. (Sarita S.N et al 2018)[60] and (Babita Yadav et al 2017) [61]. CONCLUSION There are 38 single drugs i.e., herbal, mineral and liquids has been mentioned in Bhavaprakasha Nighantu which have Panduhara action and additionally 19 drugs are mentioned in the formulations Punarnava Mandura and Navayasa Churna in Bhavaprakasha Samhitha.…”

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Panduhara drugs of Bhavaprakasha Nighantu and Samhita - A Review

Sravani

M.Ravali

Lakshmi

2023

J Ayurveda Integr Med Sci

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Pandu Roga is one of the diseases mentioned in Ayurveda characterised by pallor which is associated with different colours according to Doshas (Body humours) involved. This can be clinically corelated to Anaemia in modern science due to resemblance of signs and symptoms. Bhavaprakasha Nighantu is one of the oldest Lexicon that provides information about the Ayurvedic drugs and their properties in details. This is a literary survey based on Bhavaprakasha Nighantu and Bhavaprakasha Samhitha was aimed to find out single drugs and their properties which are used in the treatment of the disease Pandu. In Bhavaprakasha Nighantu Pandu Hara drugs are six in Haritaki Varga, nine in Guducyadi Varga, five in Vatadi Varga, eight in Dhatu Varga, three in Sakha Varga were found. The author also mentioned Dugda (milk) in Dugda Varga, Takra (buttermilk) in Takra Varga, Naveena Ghrita (freshly made ghee) in Ghrita Varga, Tushodaka (sour barley gruel) and Sukta (fermented gruel) in Sandhaniya Varga, Go-mutra (cow’s urine) in Mutra Varga as Pandu Hara. Total 38 single drugs have mentioned in Bhavaprakasha Nighantu. In Bhavaprakasha Samhita there are two main classical formulations which are useful in Pandu Roga and most of the ingredients of these formulations are similar with single drugs mentioned in Bhavapraksha Nighantu and 19 drugs are additionally found in Bhavaprakasha Samhitha.

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Clinical Efficacy and Safety ofNavayasa Churnain the Management of Iron Deficiency Anemia

Cited by 7 publications

References 68 publications

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Dhatri Lauha in the management of iron deficiency anemia

Panduhara drugs of Bhavaprakasha Nighantu and Samhita - A Review

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