Clinical efficacy and safety of dexmedetomidine and buprenorphine, butorphanol or diazepam for canine hip radiography

Leppänen, M. K.; McKusick, Brett C; Granholm, Mikael; Westerholm, Fia C; Tulamo, Riitta‐Mari; Ce, Short

doi:10.1111/j.1748-5827.2006.00030.x

Cited by 40 publications

(51 citation statements)

References 11 publications

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“…Many literatures suggested that BTR has minimal cardiovascular and respiratory effects, but when administered with α2 agonists it increases their depressant effect on heart and respiratory rates (Trim, 1983, Ko, et al, 2000, Sinclair, 2003 also bradycardiac effects of α2 agonists and butorphanol appeared to be additive (Bartram et al 1994). We proved here in our study that the DTM have the same side effects of MDM and DXM when combined with BTR (Bartram, et al, 1994, Grimm et al, 2000, Ko, et al 2000, Leppanen et al, 2006, Salla et al, 2014, Puighibet et al, 2015, Lee et al, 2016, Tamura et al, 2016.…”

Section: Resultssupporting

confidence: 67%

“…The common form of α2 agonist in pet clinics, medetomidine (MDM) showed similar effect when combined with BTR and the author's stated that MDM-BTR could be enough for sedation of dogs to perform various clinical procedures (Bartram et al 1994). The MDM and its dextro-isomer (dexmedetomidine) (DXM) also has been previously used in similar studies (Bartram et al, 1994, Grimm et al, 2000, Ko et al, 2000, Leppanen et al, 2006, Salla et al, 2014, Puighibet et al, 2015, Lee et al, 2016, Tamura et al, 2016. The same combination in other animal species also proved to be efficient for sedation and antinociception like in equine (Joubert et al, 1999, Abu-Ahmed, 2007 and in ruminant (Carroll et al, 1998, Lin andRiddell, 2003).…”

Section: Resultsmentioning

confidence: 98%

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Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Abu-Ahmed¹

2017

AJVS

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Key words:Balanced anesthesia, detomidine, nalbuphine, butorphanol, dog.The continuous search for suitable and effective drug combination for dog sedation and analgesia is an aim for most of researchers. The current experimental study aimed to evaluate and compare the sedative, analgesic and cardiorespiratory effects of detomidine/butorphanol, detomidine/nalbuphine, diazepam/butorphanol and diazepam/nalbuphine combinations in sex healthy mongrel dogs. Detomidinebutorphanol or nalbuphine resulted in deep degree of sedation and a reliable period of intense antinociceptive effect. The Longest period of sedation was recorded post diazepam-butorphanol injection. However, diazepam-nalbuphine resulted in the shortest period of both sedation and antinociception. Significant reduction of pulse and respiratory rates was observed post detomidine-opioids combination while diazepamopioids combination resulted in minimal cardiorespiratory effect. It could be concluded that detomidine-butorphanol induced a strong preemptive antinociceptive effect and a state of balanced anesthesia with minimal response to noxious stimulation.

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Section: Resultssupporting

confidence: 67%

Section: Resultsmentioning

confidence: 98%

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Abu-Ahmed¹

2017

AJVS

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“…Such myorelaxation was also observed in a study with dogs, which compared the combination of dexmedetomidine and buprenorphine with butorphanol and diazepam 16 . In the present study, the reduction of EMG values was more prominent than that of BIS values.…”

Section: Body Temperaturementioning

confidence: 81%

Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy

et al. 2010

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PURPOSE: To evaluate hemodynamics and bispectral index (BIS) in bitches anesthetized with ketamine and midazolam in combination with dexmedetomidine or medetomidine and submitted to ovariohysterectomy. METHODS: Twenty bitches pretreated with levomedetomidine and buprenorphine were anesthetized with 5 mg.kg-1 ketamine and 0.2 mg.kg-1 midazolam i.v. Continuous infusion of 0.4 mg.kg-1.h-1 midazolam and 20 mg.kg-1.h-1 ketamine was initiated in combination with DEX (n=10): 20 µg.kg-1.h-1 dexmedetomidine or MED (n=10): 30 µg.kg-1.h-1 medetomidine over 30 minutes. A pharmacokinetic study provided dexmedetomidine plasma concentration, set to be 3.0 ng.mL-1. RESULTS: BIS decreased in both groups (P<0.05), but it was lower in DEX (P<0.05) as compared to MED. No differences were found in hemodynamic parameters (heart rate, systolic, diastolic and mean arterial pressure) between groups (P>0.05), but heart rate decreased in both groups, as compared to control values (P<0.05). Respiratory rate decreased (P<0.05) and expired end tidal CO2 increased progressively (P<0.05) and similarly in both groups. Anesthetic recovery period was similar between groups (P<0.05) with no adverse effects. CONCLUSION: Continuous administration of dexmedetomidine with calculated plasma concentration equal to 3 ng.mL-1 in combination with midazolam and ketamine provides suitable anesthesia for spay surgery in bitches, hemodynamic stability and calm awakening with no adverse effects.

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“…To reduce the cardiovascular effects and keep or potentiate the sedative effects of alpha 2 agonists, several authors proposed the combination of these agents with other drugs (Leppänen et al, 2006;Monteiro et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Methadone and Dexmedetomidine Combination as Premedicant Agents for Ovariectomy in Cats

Briganti¹,

Breghi²,

Vannozzi³

et al. 2015

American Journal of Animal and Veterinary Sciences

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Abstract:The purpose of this study was to assess sedative and analgesic effects produced by the association of methadone and dexmedetomidine, administered intramuscularly as premedication for ovariectomy in cats. Twenty-four healthy cats were enrolled in the study. The values of heart and respiratory rate were recorded as Tbase. Cats received methadone 0.5 mg kg −1 and dexmedetomidine 5 mcg kg −1 IM. Sedation and ease for catheterization were scored using a simple descriptive scale ranging from 0 (no sedation) to 3 (profound sedation) and 0 (very difficult) to 3 (very easy). General anesthesia was induced with propofol and after endotracheal intubation it was maintained with isoflurane. During the surgery Heart Rate (HR), Respiratory Rate (RR), hemoglobin oxygen saturation, Doppler blood pressure, expiratory isoflurane percentage and end tidal of carbon dioxide were recorded every five minutes. At the end of the surgery all animals received robenacoxib 2 mg kg −1 subcutaneously. Recovery was scored using a simple descriptive scale ranging from 0 (poor) to 3 (excellent). The median sedation score was 2 (range 0-3); the only adverse effect associated with the premedication was vomiting occurred in 20% of the cats. No animals became excited after premedication. The median ease for catheterization was 3 (range 1-3). After premedication HR and RR showed a decrease of 28% and of 32%, respectively, in comparison to Tbase values. The median recovery score was 3 (range 1-3). No animal required additional analgesia after the surgery. The association of dexmedetomidine 5 mcg kg −1 and methadone 0.5 mg kg −1 employed in this study resulted in overall good sedation quality without any major adverse reaction. The onset of sedation was quite fast (about 7 min), suggesting synergic effect of the two molecules. Most of cats showed an easy catheterization and the recovery was excellent for the majority of cases.

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Clinical efficacy and safety of dexmedetomidine and buprenorphine, butorphanol or diazepam for canine hip radiography

Abstract: Dexmedetomidine sedative protocols, particularly in combination with butorphanol and diazepam, can be used effectively and safely in dogs for radiographic procedures.

Cited by 40 publications

References 11 publications

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy

Methadone and Dexmedetomidine Combination as Premedicant Agents for Ovariectomy in Cats

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