Clinical efficacy of a chlorhexidine‐based mouthrinse containing hyaluronic acid and an antidiscoloration system in patients undergoing flap surgery: A triple‐blind, parallel‐arm, randomized controlled trial

Trombelli, Leonardo; Simonelli, Anna; Pramstraller, Mattia; Guarnelli, Maria Elena; Fabbri, Chiara; Maietti, Elisa; Farina, Roberto

doi:10.1111/idh.12361

Cited by 13 publications

(28 citation statements)

References 38 publications

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“…In particolare, il SM è utilizzato in concentrazioni comprese tra 0,1% e 0,5% (peso/volume to- sh-out di almeno 10 giorni [20,21,32,35,36] ; soltanto lo studio di Cortellini et al [22] non prevedeva wash-out. Tre studi sono stati condotti su pazienti sottoposti a chirurgia parodontale [22,30,37] , mentre tutti gli altri non prevedevano trattamenti odontoiatrici durante i periodi sperimentali.…”

Section: Composizione E Meccanismo D'azioneunclassified

“…Tutti gli studi includevano come collutorio test il prodotto commerciale contenente CLX e l'ADS. Nella maggior parte degli studi la concentrazione di CLX del collutorio test era pari a 0,2%, mentre in alcuni studi è stata testata la concentrazione di 0,12% [20,38] ; in due studi i collutori test contenevano, oltre alla CLX, acido ialuronico e cloruro di cetilpiridinio, rispettivamente [37,39] . Il collutorio controllo (senza l'ADS) conteneva la stessa concentrazione di CLX del collutorio test; due studi prevedevano un ulteriore collutorio controllo contenente CLX 0,12% [30,39] .…”

Section: Composizione E Meccanismo D'azioneunclassified

“…Nella maggior parte degli studi i partecipanti ricevevano istruzioni di igiene orale all'arruolamento (brushing studies). In 5 studi i partecipanti non spazzolavano i denti durante i periodi sperimentali [30,32,35,38,40] (non-brushing studies), mentre in due studi venivano fornite istruzioni di igiene orale dopo 7 giorni dall'inizio dello studio (dopo la prima rilevazione) [22,37] .…”

Section: Composizione E Meccanismo D'azioneunclassified

“…Per escludere eventuali effetti confondenti nella valutazione delle pigmentazioni, la maggior parte degli studi prevedeva un controllo dei cromogeni alimentari durante il periodo sperimentale [19,21,30,32,36,37,40] ; in questi studi era fornita ai partecipanti una lista di alimenti e bevande da non consumare in prossimità dell'utilizzo del collutorio. [21,30,35,39] ; in uno studio la presenza di pigmentazioni è stata valutata mediante analisi visiva diretta e di fotografie digitali [20] .…”

Section: Composizione E Meccanismo D'azioneunclassified

“…Anche i risultati relativi all'efficacia antiplacca non sono univoci: 5 studi [21,30,32,36,37] non hanno evidenziato differenze significative tra collutori test e controllo mentre 4 studi [19,35,38,39] hanno riportato una minore attività antiplacca da parte del collutorio contenente ADS; 2 studi hanno indicato una maggiore attività antiplacca da parte del collutorio test [20,40] . [3,13,16] .…”

Section: Composizione E Meccanismo D'azioneunclassified

See 4 more Smart Citations

Pigmentazioni dentarie da clorexidina: una revisione critica

Pizzo¹,

Buttacavoli²,

Giuliana³

2020

Dental Cadmos

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Section: Composizione E Meccanismo D'azioneunclassified

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Pigmentazioni dentarie da clorexidina: una revisione critica

Pizzo¹,

Buttacavoli²,

Giuliana³

2020

Dental Cadmos

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Early periodontal wound healing after chlorhexidine rinsing: a randomized clinical trial

Graziani,

Izzetti,

Perić

et al. 2024

Clin Oral Invest

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Objectives This single-center randomized, parallel design, clinical trial with a 2-week follow-up involved patients affected by periodontitis undergoing periodontal surgery. The aim was to evaluate periodontal surgical wound healing with the use of chlorhexidine-based mouth rinses versus an untreated control group. Materials and methods Periodontal surgery was performed following a standardized protocol. Patients were randomly prescribed i) chlorhexidine (CHX) + anti-discoloration system (ADS) + hyaluronic acid (HA), ii) CHX + ADS or iii) no treatment (control group). Plaque score, gingival inflammation, and Early Healing Index (EHI), assessing the degree of wound closure and the presence of fibrin and necrosis, were evaluated at 3, 7 and 14 days after surgery. Results In total, 33 patients were enrolled. Patients were comparable at baseline for all measured clinical parameters. At 3-days wound healing was significantly improved in all patients treated with CHX + ADS-based mouth rinses with a lower EHI score at the interdental papillae compared with control group (p < 0.01). CHX + ADS + HA group presented improved healing across all time points in terms of EHI, plaque containment, and gingival inflammation when compared to control group (p < 0.01). Conclusions The usage of CHX-ADS following periodontal surgery improved early wound healing, reduced plaque accumulation and gingival inflammation. During the early post-operative period the adjunct of HA further improved soft tissue closure. Clinical relevance This study aims at evaluating the response of gingival tissues to mouth rinsing with chlorhexidine and anti-discoloration system (CHX + ADS) or CHX + ADS + hyaluronic acid (CHX + ADS + HA) versus no rinse in terms of healing of the periodontal surgical wound. CHX + ADS mouth rinses enhanced early soft tissue closure after periodontal surgery and contributed to the reduction in plaque accumulation and gingival inflammation. The adjunct of HA may be beneficial especially in the early post-operative period. CHX + ADS administration following periodontal surgery may improve soft tissue healing in the first two post-operative weeks.

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Tolerability of a green tea-based mouth rinse: A pilot study

Abdulkarim

Alsubhi

bukhari

et al. 2019

The Saudi Dental Journal

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IntroductionMouth rinse containing essential oil is one of the most popular, over the counter dental products which has been promoted to have anti-inflammatory, anti-plaque and anti-microbial properties. An essential oil alcohol-free mouth rinse with green tea has been introduced recently and promoted for management of periodontitis and gingivitis. As the role of chlorhexidine gluconate (CHX) mouth rinse in management of periodontal disease has been evaluated previously, the aim of this study is to compare the tolerability of none-alcohol containing green tea-based (NAGT) mouth rinse with CHX mouth rinse.MethodsForty healthy subjects were enrolled in September 2018 at King Abdulaziz University and allocated randomly to two study arms: NAGT mouth rinse and chlorhexidine gluconate mouth rinse. Study subjects were instructed to follow the manufacturer instructions and rinse twice daily for two weeks. Collected data included age, gender, smoking history in addition to subjective assessment using a validated questionnaire. Intraoral clinical examination was completed at baseline and 2-weeks time point.ResultsThe data of 36 patients were included in this study and analyzed. At 2 weeks, NAGT group reported higher burning sensation score compared to chlorhexidine group (mean: 4.33 and 0.6 respectively; P < 0.05). Reported mucosal dryness was more evident in NAGT group (mean: 1.9 Vs 1.7 for chlorhexidine group). Oral examination revealed significant mucosal desquamation (27.8%) in NAGT group. However, oral ulceration was reported equally in both groups (5.6%).ConclusionThe current data demonstrates an overall less tolerability of a non-alcohol containing green tea-based mouth rinse compared to chlorhexidine gluconate. Further long term randomized clinical trials are recommended to confirm our findings.

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Clinical efficacy of a chlorhexidine‐based mouthrinse containing hyaluronic acid and an antidiscoloration system in patients undergoing flap surgery: A triple‐blind, parallel‐arm, randomized controlled trial

Abstract: Postsurgery plaque control based on either CHX or CHX + HA + ADS mouthrinses results in optimal plaque control and quality of early gingival healing along with limited tooth and tongue staining.

Cited by 13 publications

References 38 publications

Pigmentazioni dentarie da clorexidina: una revisione critica

Pigmentazioni dentarie da clorexidina: una revisione critica

Early periodontal wound healing after chlorhexidine rinsing: a randomized clinical trial

Tolerability of a green tea-based mouth rinse: A pilot study

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