Clinical efficacy of botanical extracts from Eupatorium adenophorum against the Sarcoptes scabiei (Sarcoptidae: Sarcoptes) in rabbits

Nong, Xiang; Ren, Yongjun; Wang, Jiahai; Xie, Yue; Fang, Chunlin; Yang, Dapeng; Liu, Tianfei; Zhang, Runhui; Chen, Lin; Gu, Xiaobin; Peng, Xuerong; Wang, Shuxian; Lai, Songjia; Yang, Guangyou

doi:10.1016/j.vetpar.2013.02.020

Cited by 25 publications

(18 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A single topical dose of selamectin at 10-12 mg/kg reduced the number of mites found on skin scrapings of Angora rabbits (Kurtdede et al, 2007) and eliminated clinical signs and parasitic infestation in a group of mixed-breed rabbits at a dose of 30 mg/rabbit (Farmaki et al, 2009). (Nong et al, 2013). (Nong et al, 2013).…”

Section: Treatment Prevention and Controlmentioning

confidence: 99%

Biology and Diseases of Rabbits

Nowland

Brammer

García

et al. 2015

Laboratory Animal Medicine

View full text Add to dashboard Cite

Section: Treatment Prevention and Controlmentioning

confidence: 99%

Biology and Diseases of Rabbits

Nowland

Brammer

García

et al. 2015

Laboratory Animal Medicine

View full text Add to dashboard Cite

“…At present, many aspects of E.adenophorum are being studied widely [5]. Previous study indicated that E. adenophorum has the acaricidal activity [6–8], antitumor activity [9, 10], potential anti-inflammatory and other biological activities [11]. The previous reports showed that purified extracts from E. adenophorum could cause hepatotoxicity of mice and livestock [8, 12–15], especially the 9-oxo-10,11-dehydro-agerophorone which is the main poisonous components of E. adenophorum [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

Luo

et al. 2016

Oncotarget

Self Cite

View full text Add to dashboard Cite

E. adenophorum has reported to cause hepatotoxicity. But, the precise effects of E. adenophorum on hepatocytes is unclear. Saanen goats were fed on E. adenophorum to detect the cytotoxicity effects of E. adenophorum on hepatocytes. Our study has shown that the typical apoptotic features, the increasing apoptotic hepatocytes and activated caspase-9, −3 and the subsequent cleavage of PARP indicated the potent pro-apoptotic effects of E. adenophorum. Moreover, the translocation of Bax and Cyt c between mitochondria and cytosol triggering the forming of apoptosome proved that the mitochondria-mediated apoptosis was triggered by E. adenophorum. Furthermore, E. adenophorum increased the MDC-positive autophagic vacuoles and the subcellular localization of punctate LC3, the ratio of LC3-II/LC3-I and the protein levels of Beclin 1, but decreased that of P62, indicating the potent pro-autophagic effects of E. adenophorum. In addition, E. adenophorum significantly inhibited the protein leves of p-PI3K, p-Akt and p-mTORC1, but increased PTEN and p-AMPK. Also, the p-mTORC2 and p-Akt Ser473 were inhibited, indicating that the supression of mTORC2/Akt pathway could induce the autophagy of hepatocytes. The autophagy-realted results indicated that the inhibition of PI3K/Akt/mTORC1- and mTORC2/Akt-mediated pathways contributed to the pro-autophagic activity of E. adenophorum. These findings provide new insights to understand the mechanisms involved in E. adenophorum-caused hepatotoxicity of Saanen goat.

show abstract

“…To test the activity against S. scabiei, 10 specimens were placed on the filter paper in the Petri dishes and incubated at 25˚C under 75% relative humidity for 0.5, 1, 2, 4 or 6 h (16,17). Three replicates were performed for each concentration of the extract.…”

Section: Methodsmentioning

confidence: 99%

Acaricidal activity of extracts from Ligularia virgaurea against the Sarcoptes scabiei mite in vitro

Luo

Liao

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

The aim of the present study was to investigate the acaricidal activity of . An extract was prepared by refluxing with ethanol and steam distillation, and its toxic effect was tested against . The data from the toxicity tests were analyzed using a complementary log-log (CLL) model. The ethanol extract exhibited strong acaricidal activity against these mites; at a concentration of 2 g/ml it killed all within 2 h and at 1 g/ml it killed all within 6 h. Similarly, 2, 1, 0.5 and 0.25 g/ml concentrations of the extract had strong toxicity against, with median lethal time (LT) values of 0.716, 1.741, 2.968 and 4.838 h, respectively. The median lethal concentration (LC) values were 1.388, 0.624, 0.310 and 0.213 g/ml for mite in 1, 2, 4 and 6 h, respectively. The results indicate that the extract has strong acaricidal activity and may be exploited as a novel treatment for the effective control of acariasis in animals.

show abstract

Clinical efficacy of botanical extracts from Eupatorium adenophorum against the Sarcoptes scabiei (Sarcoptidae: Sarcoptes) in rabbits

Cited by 25 publications

References 39 publications

Biology and Diseases of Rabbits

Biology and Diseases of Rabbits

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

Acaricidal activity of extracts from Ligularia virgaurea against the Sarcoptes scabiei mite in vitro

Contact Info

Product

Resources

About