Clinical efficacy of chlorhexidine chips and tetracycline fibers as an adjunct to non surgical periodontal therapy

Singh, Munishwar; Shreehari, AK; Garg, Pankaj Kumar; Singh, Sangeeta

doi:10.4103/2278-9626.134840

Cited by 5 publications

(10 citation statements)

References 19 publications

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“…[ 2 9 10 11 13 17 18 19 20 ] Seven articles were retrieved after electronic search of medical database and included for reading full text[ 2 11 12 14 19 20 21 ] and four articles were included after hand search. [ 9 10 13 18 ] Unpublished data of two studies were obtained from approval letter available at center for drug evaluation and research, USA. [ 17 ] Three articles were excluded for the reason as no random concealed allocation or blinding done,[ 14 ] cases of aggressive periodontitis were also included[ 12 ] and results of control group not available [ Figure 1 ].…”

Section: Resultsmentioning

confidence: 99%

“…Two out of ten included studies were conducted in USA[ 17 ] and one in Brazil;[ 18 ] others were conducted in India. [ 2 9 10 11 13 19 20 ] The number of sites in studies ranged from 13 to 140. The age of the subjects included ranged from 20 to 75 years.…”

Section: Resultsmentioning

confidence: 99%

“…Of ten included studies, only one had used doxycycline as LDD,[ 20 ] six studies had used 2% minocycline gel[ 2 13 17 18 19 ] where remaining three had used 8% tetracycline fibers. [ 9 10 11 ] Follow-up period varies from 3 to 9 months [ Table 2 ]. Seven studies evaluated PD after 3 months, five did follow-up for 6 months and four followed up the participants for 9 months.…”

Section: Resultsmentioning

confidence: 99%

“…Recent trials[ 2 9 10 11 12 13 14 15 ] evaluated sustained release system incorporating tetracycline gave promising results except one study,[ 2 ] but pooling of data of such trials and its quality assessment is required before implementing in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis

Nadig

Shah

2016

J Indian Soc Periodontol

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Background:The aim of the present meta-analysis is to determine the efficacy of tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis.Materials and Methods:MEDLINE, EBSCO, Cochrane database, and Google Scholar were used to identify studies in English published up to January 31, 2017. An additional hand search of relevant journals and of the bibliographies of the paper identified was also performed. Articles retrieved were screened using specific inclusion criteria by two independent reviewers. Randomized control trials investigating the effect of tetracycline group of antibiotics as local drug delivery agents in chronic periodontitis were included in the study.Results:Ten relevant articles were selected for the meta-analysis, of which five articles were retrieved after electronic search, three articles were included after hand search, and two unpublished articles were included. The number of patients in studies ranged from 13 to 140 sites with mean age ranging from 20 to 75. A total of 588 sites were treated using tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. The meta-analysis showed standard difference in mean −1.02 mm (95% confidence interval [CI] 0.28, 1.75) for clinical gain in attachment in favor of tetracycline group. Standard difference in mean for probing depth (PD) was 1.20 mm (95% CI 0.57, 1.87) in tetracycline group.Conclusion:The results of this meta-analysis showed a significant improvement in periodontal parameters such as CAL, PD, and sulcular bleeding index in favor of tetracycline as local drug delivery compared to placebo.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis

Nadig

Shah

2016

J Indian Soc Periodontol

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“…Untuk mengurangi kendala tersebut, dalam beberapa tahun terakhir, tetrasiklin dibuat dalam bentuk sediaan chip yang terbuat dari kolagen. 12 Chip ini memiliki kekurangan, yaitu harganya yang cukup mahal dan sifatnya yang harus diambil kembali dari poket karena tidak dapat diresorpsi tubuh secara alami.…”

Section: Pendahuluanunclassified

Pengaruh Lama Perendaman terhadap Absorpsi Tetrasiklin pada Adsorben Limbah Sisik Ikan Gurami (Osphronemus Gouramy)

Pratama

Barqly

Widyastuti

et al. 2016

Majalah Kedokteran Gigi Indonesia

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Sisik ikan gurami (Osphronemus Gouramy) merupakan salah satu sumber alternatif kolagen alami yang bersifat biodegradable (mudah terurai) dan bio-compatible (kompatibel dengan jaringan sekitarnya) serta memiliki potensi sebagai bioadsorben. Sifat bioadsorben kolagen ini sudah dimanfaatkan sebagai media transport antibiotik tetrasiklin dalam bentuk chip, yang digunakan sebagai antibiotik lokal dalam perawatan periodontitis. Kekurangan chip ini yaitu harganya mahal serta harus diambil kembali dari jaringan gingiva karena tidak dapat diresorpsi tubuh. Potensi bioadsorben sisik dari ikan gurami diduga dapat dimanfaatkan sebagai media transport tetrasiklin dalam bidang biomedis. Penelitian ini bertujuan untuk mengetahui potensi absorbsi, kadar absorbsi serta pengaruh lama perendaman limbah sisik ikan gurami terhadap absorbsi antibiotik tetrasiklin. Sampel penelitian berupa sisik ikan gurami yang didapat dari rumah makan seafood di daerah Jember, Jawa Timur. Sebanyak 500 mg sisik ikan direndam ke dalam 20 ml larutan induk tetrasiklin hidroklorida dalam beaker glass. Larutan diambil sebanyak 200 μl dengan mikropipet pada jam ke-0, jam ke-1, jam ke-2, jam ke-4, jam ke-12 dan jam ke-24 setelah perendaman. Absorbansi sisik ikan gurami terhadap tetrasiklin pada masing-masing interval waktu perendaman dibaca menggunakan spektrofotometer dengan panjang gelombang 450nm. Tahapan ini diulangi sebanyak lima kali. Hasilnya kadar tetrasiklin dalam larutan pada lama perendaman 1 jam menunjukkan kadar terendah yaitu 160,6 μg/μl. Dari pengamatan mikroskopis terlihat adanya ikatan antara tetrasiklin dan kolagen sisik ikan. Sisik ikan gurami dapat mengabsorbsi tetrasiklin dengan lama perendaman efektif yaitu 1 jam dengan mekanisme ikatan antara kolagen sisik ikan dengan kristal tetrasiklinInfluence of Immersion Length on Tetracycline Absorption on Gourami (Osphronemus Gouramy) Scales as Adsorbent. Gourami (Osphronemus Gouramy) scales are one of the natural sources of collagen. This fish scale’s collagen has functional properties, such as bio-degradable (easily decomposed), bio-compatible (compatible with surrounding tissue), and potential as bio-adsorbent. The absorbent properties of collagen are currently used as a transport material in local drug delivery for periodontal disease treatment, which is known as tetracycline chip. However, this chip is made of synthetic collagen so it is not absorbable by the body’s system. The price is also expensive. This study’s aim is to prove the potency of Gourami scales as a source of collagen in medical treatment, especially as a transport material of tetracycline for periodontal disease treatment. The gourami scale was obtained from seafood restaurant in Jember, Jawa Timur. About 500 mg of gourami scales was immersed into 20 ml tetracycline solution in beaker glass. About 200 μl solution from the beaker glass was taken with micropipette after 1-hour, 2-hour, 4-hour, 12-hour and 24-hour after immersed. After that, the solution was collected into an eppendorf for each time. The absorbance was measured with spectrophotometer at 450 nm wave length. This procedure was repeated five times. The lowest absorbance occured at 1-hour time (160,6 μg/μl). The result from light and inverted microscope examination shows a bond between collagen from gourami scales with tetracycline. Gourami scale has the ability to absorb the highest rate of tetracycline at 1-hour immersed time by forming a bond between collagen and tetracycline.

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Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Clinical Trial

Singh¹,

Sridhar

Shrihatti³

et al. 2018

The Journal of Alternative and Complementary Medicine

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Clinical efficacy of chlorhexidine chips and tetracycline fibers as an adjunct to non surgical periodontal therapy

Cited by 5 publications

References 19 publications

Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis

Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis

Pengaruh Lama Perendaman terhadap Absorpsi Tetrasiklin pada Adsorben Limbah Sisik Ikan Gurami (Osphronemus Gouramy)

Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Clinical Trial

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