Clinical efficacy of intravenous immunoglobulin in patients with severe inflammatory chest disease and IgG3 subclass deficiency

Bernatowska, Ewa; Pac, Małgorzata; Skopcynska, H.; Pum, M.; Eibl, Martha M.

doi:10.1111/j.1365-2249.1991.tb05703.x

Cited by 23 publications

(7 citation statements)

References 9 publications

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“…Several studies have demonstrated that IgG subclass deficiency and impairment of antibody production are frequent findings in this group of patients [19,20]. In our early studies IgG3 deficiency was the most common [18].…”

Section: Discussionmentioning

confidence: 98%

“…CRS may be related stronger to allergy than to humoral immunologic defect and ongoing allergic inflammation may contribute to sinus pathology. The group of children with IgG3 subclass deficiency, upper and lower respiratory tract infections with bronchitis and severe steroid-dependent asthma was studied [19]. During the first year of observation patients received conventional treatment with antibiotics and antiasthmatics.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic rhinosinusitis in primary antibody immunodeficient patients

Bernatowska¹,

Mikołuć²,

Krzeski³

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Chronic rhinosinusitis in primary antibody immunodeficient patients

Bernatowska¹,

Mikołuć²,

Krzeski³

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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“…Associations between IgG3 responses and improved infectious disease outcomes have also been observed for chikungunya and plasmodium infection [15,[18][19][20][21], among others. Furthermore, individuals with reduced or deficient serum levels of IgG3 tend to have recurrent upper respiratory infections [22][23][24][25]. Collectively, these clinical associations and subclass switch experiments suggest the functional importance of the IgG3 subclass.…”

Section: Introductionmentioning

confidence: 94%

Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies

et al. 2020

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Antibody functions such as neutralization require recognition of antigen by the Fab region, while effector functions are additionally mediated by interactions of the Fc region with soluble factors and cellular receptors. The efficacy of individual antibodies varies based on Fab domain characteristics, such as affinity for antigen and epitope-specificity, and on Fc domain characteristics that include isotype, subclass, and glycosylation profile. Here, a series of HIV-specific antibody subclass and hinge variants were constructed and tested to define those properties associated with differential effector function. In the context of the broadly neutralizing CD4 binding site-specific antibody VRC01 and the variable loop (V3) binding antibody 447-52D, hinge truncation and extension had a considerable impact on the magnitude of phagocytic activity of both IgG1 and IgG3 subclasses. The improvement in phagocytic potency of antibodies with extended hinges could not be attributed to changes in either intrinsic antigen or antibody receptor affinity. This effect was specific to phagocytosis and was generalizable to different phagocytes, at different effector cell to target ratios, for target particles of different size and composition, and occurred across a range of antibody concentrations. Antibody dependent cellular cytotoxicity and neutralization were generally independent of hinge length, and complement deposition displayed variable local optima. In vivo stability testing showed that IgG molecules with altered hinges can exhibit similar biodistribution and pharmacokinetic profiles as IgG1. Overall, these results suggest that when high phagocytic activity is desirable, therapeutic antibodies may benefit from being formatted as human IgG3 or engineered IgG1 forms with elongated hinges.

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“…A sample size of 21 had 80% power at a 5% level of significance to detect differences in the proportion of asthma exacerbations before and after treatment, based on previous data. 17 To allow for the possibility of up to 30% of participants withdrawing early from the study, a recruitment target of 30 participants was set. The intention-to-treat (ITT) population comprised all subjects who received at least 1 IVIG infusion; the per-protocol (PP) population comprised the subjects in the ITT population without full protocol deviations.…”

Section: Methodsmentioning

confidence: 99%

Effects of Immunoglobulin Replacement on Asthma Exacerbation in Adult Asthmatics with IgG Subclass Deficiency

Kim

Ban

et al. 2017

Allergy Asthma Immunol Res

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PurposeRecurrent respiratory tract infection is a common manifestation of primary immunodeficiency disease, and respiratory viruses or bacteria are important triggers of asthma exacerbations. Asthma often coexists with humoral immunodeficiency in adults, and some asthmatics with immunoglobulin (Ig) G subclass deficiency (IgGSCD) suffer from recurrent exacerbations. Although some studies suggest a benefit from Ig replacement, others have failed to support its use. This study aimed to assess the effect of Ig replacement on asthma exacerbation caused by respiratory infection as well as the asthma control status of adult asthmatics with IgGSCD.MethodsThis is a multi-center, open-label study of adult asthmatics with IgGSCD. All patients received monthly intravenous immunoglobulin (IVIG) for 6 months and were evaluated regarding asthma exacerbation related to infection, asthma control status, quality of life, and lung function before and after IVIG infusion.ResultsA total of 30 patients were enrolled, and 24 completed the study. Most of the patients had a moderate degree of asthma severity with partly (52%) or uncontrolled (41%) status at baseline. IVIG significantly reduced the proportion of patients with asthma exacerbations, lowered the number of respiratory infections, and improved asthma control status, compared to the baseline values (P<0.001). The mean asthma-specific quality of life and asthma control test scores were improved significantly (P=0.009 and P=0.053, respectively); however, there were no significant changes in lung function.ConclusionsIVIG reduced the frequency of asthma exacerbations and improved asthma control status in adult asthmatics with IgGSCD, suggesting that IVIG could be an effective treatment option in this population.

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Clinical efficacy of intravenous immunoglobulin in patients with severe inflammatory chest disease and IgG3 subclass deficiency

Cited by 23 publications

References 9 publications

Chronic rhinosinusitis in primary antibody immunodeficient patients

Chronic rhinosinusitis in primary antibody immunodeficient patients

Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies

Effects of Immunoglobulin Replacement on Asthma Exacerbation in Adult Asthmatics with IgG Subclass Deficiency

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