Clinical efficacy of leukofiltration on cardiopulmonary bypass related inflammatory response: Fact or Foe?

During critical illness, dramatic alterations in neutrophil biology are observed including abnormalities of granulopoeisis and lifespan, cell trafficking and antimicrobial effector functions. As a result, neutrophils transition from powerful antimicrobial protectors into dangerous mediators of tissue injury and organ dysfunction. In this article, the role of neutrophils in the pathogenesis of critical illness (sepsis, trauma, burns and others) will be explored, including pathological changes to neutrophil function during critical illness and the utility of monitoring aspects of the neutrophil phenotype as biomarkers for diagnosis and prognostication. Lastly, we review findings from clinical trials of therapies that target the harmful effects of neutrophils, providing a bench-to-bedside perspective on neutrophils in critical illness.

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Leukocyte Filtration Ameliorates the Inflammatory Response in Patients With Mild to Moderate Lung Dysfunction

Onorati

Santini

Mariscalco

et al. 2011

The Annals of Thoracic Surgery

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Clinical efficacy of leukofiltration on cardiopulmonary bypass related inflammatory response: Fact or Foe?

Abstract: Leukocyte filtration on coated surfaces alleviated systemic inflammatory response with a better clinical outcome in high risk patients.

Cited by 7 publications

References 22 publications

Effects of interventions targeting the systemic inflammatory response to cardiac surgery on clinical outcomes in adults

Effects of interventions targeting the systemic inflammatory response to cardiac surgery on clinical outcomes in adults

Neutrophils in critical illness

Leukocyte Filtration Ameliorates the Inflammatory Response in Patients With Mild to Moderate Lung Dysfunction

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