Clinical efficacy of mineralized collagen (MC) versus anorganic bovine bone (Bio-Oss) for immediate implant placement in esthetic area: a single-center retrospective study

Dai, Yan; Xu, Jin; Han, Xiaohui; Cui, Fuzhai; Zhang, Dongsheng; Huang, Shengyun

doi:10.1186/s12903-021-01752-4

Cited by 8 publications

(6 citation statements)

References 31 publications

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“…DIPY, an indirect adenosine agonist, is an extensively studied biologic compound [ 55 , 62 , 63 , 64 , 65 , 65 , 66 , 67 , 67 , 68 , 68 , 69 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 ]. Historically, it has been used as a vasodilatory and antiplatelet agent [ 98 , 99 , 100 , 101 ].…”

Section: Resultsmentioning

confidence: 99%

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Translational Experimental Basis of Indirect Adenosine Receptor Agonist Stimulation for Bone Regeneration: A Review

Ehlen,

Mirsky,

Slavin

et al. 2024

IJMS

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Bone regeneration remains a significant clinical challenge, often necessitating surgical approaches when healing bone defects and fracture nonunions. Within this context, the modulation of adenosine signaling pathways has emerged as a promising therapeutic option, encouraging osteoblast activation and tempering osteoclast differentiation. A literature review of the PubMed database with relevant keywords was conducted. The search criteria involved in vitro or in vivo models, with clear methodological descriptions. Only studies that included the use of indirect adenosine agonists, looking at the effects of bone regeneration, were considered relevant according to the eligibility criteria. A total of 29 articles were identified which met the inclusion and exclusion criteria, and they were reviewed to highlight the preclinical translation of adenosine agonists. While preclinical studies demonstrate the therapeutic potential of adenosine signaling in bone regeneration, its clinical application remains unrealized, underscoring the need for further clinical trials. To date, only large, preclinical animal models using indirect adenosine agonists have been successful in stimulating bone regeneration. The adenosine receptors (A1, A2A, A2B, and A3) stimulate various pathways, inducing different cellular responses. Specifically, indirect adenosine agonists act to increase the extracellular concentration of adenosine, subsequently agonizing the respective adenosine receptors. The agonism of each receptor is dependent on its expression on the cell surface, the extracellular concentration of adenosine, and its affinity for adenosine. This comprehensive review analyzed the multitude of indirect agonists currently being studied preclinically for bone regeneration, discussing the mechanisms of each agonist, their cellular responses in vitro, and their effects on bone formation in vivo.

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Section: Resultsmentioning

confidence: 99%

“…3.3.1. DIPY DIPY, an indirect adenosine agonist, is an extensively studied biologic compound [55,[62][63][64][65][65][66][67]67,68,68,69,[81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97]. Historically, it has been used as a vasodilatory and antiplatelet agent [98][99][100][101].…”

Section: Indirect Agonistsmentioning

confidence: 99%

Translational Experimental Basis of Indirect Adenosine Receptor Agonist Stimulation for Bone Regeneration: A Review

Ehlen,

Mirsky,

Slavin

et al. 2024

IJMS

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“…The alveolar process contracts to a certain extent due to the reduction of the biomechanical stimulation and the physiological remodeling of the alveolar bone to fill the postextraction space. − Some studies showed that bone remodeling results in 40–60% of the vertical and horizontal bone loss during the first two years of alveolar bone healing. , Bio-Oss is widely used in clinical practice for the preservation of the alveolar ridge, achieving good results to some extent. However, it is prone to collapse, and it does not maintain a good and stable shape . Hence, the ideal material for alveolar bone healing has not yet been found.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is prone to collapse, and it does not maintain a good and stable shape. 7 Hence, the ideal material for alveolar bone healing has not yet been found.…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin/Collagen/Hydroxyapatite Scaffolds Obtained by 3D Printing Technology and Loaded with Recombinant Human Erythropoietin in the Reconstruction of Alveolar Bone Defects

Liu

Wang

Sun

et al. 2022

ACS Biomater. Sci. Eng.

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The fast osteogenesis of the large alveolar fossa and the maintenance of the height of the alveolar ridge after tooth extraction have always been a clinical challenge. Therefore, this work describes the creation of innovative silk fibroin/collagen/ hydroxyapatite (SCH) biological scaffolds by 3D printing technology, which are loaded with recombinant human erythropoietin (rh-EPO) for the reconstruction of bone defects. Low-temperature 3D printing can maintain the biological activity of silk fibroin and collagen. The SCH scaffolds showed the ideal water absorption and porosity, being a sustained-release carrier of rh-EPO. The optimized scaffolds had ideal mechanical properties in vitro, and MC3T3-E1 cells could easily adhere and proliferate on it. In vivo experiments in rabbits demonstrated that the composite scaffolds gradually degraded and promoted the accumulation and proliferation of osteoblasts and the formation of collagen fibers, significantly promoting the reconstruction of mandibular defects. In this study, a novel composite biological scaffold was prepared using 3D printing technology, and the scaffold was innovatively combined with the multifunctional growth factor rh-EPO. This provides a new optimized composite material for the reconstruction of irregular mandible defects, and this biomaterial is promising for clinical reconstruction of alveolar bone defects.

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“…ICBM mainly consists of collagen type I [ 7 ], whereas BioOss ® Collagen consists of a mixture of cancellous granules and collagen [ 8 ]. ICBM is predominately used in research settings [ 6 , 7 ], BioOss ® is often used in clinical routines [ 9 , 10 ]. Augmentative results of xenogeneic materials vary in literature [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Xenogeneic and Alloplastic Carriers for Bone Augmentation on Human Unrestricted Somatic Stem Cells

et al. 2022

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Alloplastic and xenogeneic bone grafting materials are frequently used for bone augmentation. The effect of these materials on precursor cells for bone augmentation is yet to be determined. The aim of this study was to ascertain, in vitro, how augmentation materials influence the growth rates and viability of human unrestricted somatic stem cells. The biocompatibility of two xenogeneic and one alloplastic bone graft was tested using human unrestricted somatic stem cells (USSCs). Proliferation, growth, survival and attachment of unrestricted somatic stem cells were monitored after 24 h, 48 h and 7 days. Furthermore, cell shape and morphology were evaluated by SEM. Scaffolds were assessed for their physical properties by Micro-CT imaging. USSCs showed distinct proliferation on the different carriers. Greatest proliferation was observed on the xenogeneic carriers along with improved viability of the cells. Pore sizes of the scaffolds varied significantly, with the xenogeneic materials providing greater pore sizes than the synthetic inorganic material. Unrestricted somatic stem cells in combination with a bovine collagenous bone block seem to be very compatible. A scaffold’s surface morphology, pore size and bioactive characteristics influence the proliferation, attachment and viability of USSCs.

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Clinical efficacy of mineralized collagen (MC) versus anorganic bovine bone (Bio-Oss) for immediate implant placement in esthetic area: a single-center retrospective study

Cited by 8 publications

References 31 publications

Translational Experimental Basis of Indirect Adenosine Receptor Agonist Stimulation for Bone Regeneration: A Review

Translational Experimental Basis of Indirect Adenosine Receptor Agonist Stimulation for Bone Regeneration: A Review

Silk Fibroin/Collagen/Hydroxyapatite Scaffolds Obtained by 3D Printing Technology and Loaded with Recombinant Human Erythropoietin in the Reconstruction of Alveolar Bone Defects

Influence of Xenogeneic and Alloplastic Carriers for Bone Augmentation on Human Unrestricted Somatic Stem Cells

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