Clinical efficacy of N-acetylcysteine for COVID-19: A systematic review and meta-analysis of randomized controlled trials

Liu, Ting-Hui; Wu, Jheng-Yan; Huang, Po-Yu; Tsai, Ya-Wen; Hsu, Wan-Hsuan; Chuang, Min-Hsiang; Tang, Hung-Jen; Lai, Chih-Cheng

doi:10.1016/j.heliyon.2024.e25179

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e25179

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Clinical efficacy of N-acetylcysteine for COVID-19: A systematic review and meta-analysis of randomized controlled trials

Ting-Hui Liu,

Jheng-Yan Wu,

Po-Yu Huang

et al.

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2024

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Role of Biomarkers Diagnostic Tools in Patients with COVID-19: Stratification Made Easy

Salman,

Abdallah,

Eldahdouh

et al. 2024

IJGM

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Background and Aims In coronavirus disease 2019 (COVID-19) patients, several serum biomarkers have been identified. Upon intensive care unit (ICU) admission, these laboratory markers become more crucial to distinguish between patients with severe cases of COVID-19. It might assist doctors in predicting the course of illnesses and treating patients appropriately. This work was to investigate the role of biomarkers in patients with COVID-19 classification admitted to the hospital and identified by reverse transcription polymerase chain reaction (RT-PCR). Methods Peripheral blood sample was taken from COVID-19 cases isolated on admission to determine C-reactive protein (CRP), D-dimer, Fibrinogen, neutrophil–lymphocyte ratio (NLR), leukocytes CRP ratio (LeCR), lymphocyte–CRP ratio (LCR), interleukin-6 (IL6), leukocytes interleukin 6 ratio (LeIL6), systemic inflammatory index (SII), platelet-to-lymphocyte ratio (PLR), and tissue plasminogen activator inhibitor one (tPAI-1). Follow-up for IL6, Ferritin, D-dimer, and tPAI-1 were determined on the 3 rd and 7 th days. Results Comparisons of severity revealed that hypertension, chronic obstructive pulmonary disease (COPD), and Ischemia were major risk factors in COVID-19 patients. There was a statistically significant difference between the test groups for fibrinogen (p < 0.000), IL6 (p < 0.009), LeCR (p < 0.006), and LCR (p < 0.011). Conclusion Based on laboratory test findings at the time of ICU admission, we can distinguish severe cases of COVID-19.

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Role of Biomarkers Diagnostic Tools in Patients with COVID-19: Stratification Made Easy

Salman,

Abdallah,

Eldahdouh

et al. 2024

IJGM

View full text Add to dashboard Cite

show abstract

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Clinical efficacy of N-acetylcysteine for COVID-19: A systematic review and meta-analysis of randomized controlled trials

Cited by 1 publication

References 20 publications

Role of Biomarkers Diagnostic Tools in Patients with COVID-19: Stratification Made Easy

Role of Biomarkers Diagnostic Tools in Patients with COVID-19: Stratification Made Easy

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