Clinical efficacy of photodynamic therapy as an adjunct to mechanical debridement in the treatment of per-implantitis with abscess

Almohareb, Thamer; Alhamoudi, Nawaf; Deeb, Modhi Al; Bin-Shuwaish, Mohammed S.; Mokeem, Sameer A; Shafqat, Syed Saad; Vohra, Fahim; Abduljabbar, Tariq

doi:10.1016/j.pdpdt.2020.101750

Cited by 46 publications

(42 citation statements)

References 27 publications

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“…Secondary outcomes were also determined in the present research ( Table 3 ). Eleven papers [ 6 , 17 , 22 , 24 , 30 , 49 , 50 , 51 , 52 , 53 , 54 ] reported bone loss. A generalized reduction of approximately 0.75 mm was obtained after 12 months of follow-up ( Table 3 ) when systemic antibiotics were administrated in conjunction with other therapies, such as mechanical debridement, bone graft plus membrane or even titanium granulates.…”

Section: Resultsmentioning

confidence: 99%

“…A generalized reduction of approximately 0.75 mm was obtained after 12 months of follow-up ( Table 3 ) when systemic antibiotics were administrated in conjunction with other therapies, such as mechanical debridement, bone graft plus membrane or even titanium granulates. Plaque score was also analyzed in eleven studies [ 1 , 6 , 16 , 22 , 47 , 48 , 50 , 52 , 54 , 56 , 57 ]. Plaque scores in all groups were significantly reduced from baseline to successive follow-up periods when systemic antibiotics were used in combination with complementary therapies.…”

Section: Resultsmentioning

confidence: 99%

“…Plaque scores in all groups were significantly reduced from baseline to successive follow-up periods when systemic antibiotics were used in combination with complementary therapies. Suppuration was determined in eight articles [ 6 , 24 , 47 , 48 , 50 , 52 , 53 , 57 ], and most showed a significant reduction after systemic antibiotic administration. Eight articles [ 1 , 6 , 16 , 24 , 30 , 55 , 56 , 57 ] also reported total bacterial counts, and Prevotella intermedia / nigrescens , Porphyromonas gingivalis , and Aggregatibacter actinomycetemcomitans were some of the most common bacteria associated with peri-implantitis.…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of Systemic Antibiotic Therapy in the Treatment of Peri-Implantitis

Toledano-Osorio

Vallecillo

Toledano³

et al. 2022

IJERPH

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Research has been conducted into the advantages of the systemic administration of antibiotics. The aim of this systematic review and meta-analysis was to assess the efficacy of systemic antibiotic administration in the treatment of peri-implantitis in terms of bleeding on probing (BoP) and probing pocket depth (PPD). Literature searches were performed across PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) to identify randomized controlled trials and observational clinical studies. After peri-implantitis treatment, PPD was reduced by 0.1 mm (p = 0.58; IC 95% [−0.24, 0.47]), indicating a non-significant effect of antibiotic administration on PPD. The BoP odds ratio value was 1.15 (p = 0.5; IC 95% [0.75, 1.75]), indicating that the likelihood of bleeding is almost similar between the test and control groups. Secondary outcomes were found, such as reduced clinical attachment level, lower suppuration and recession, less bone loss, and a reduction in total bacterial counts. In the treatment of peri-implantitis, the systemic antibiotic application reduces neither PPD nor BoP. Therefore, the systemic administration of antibiotics, in the case of peri-implantitis, should be rethought in light of the present results, contributing to address the problem of increasing antibiotic resistance.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of Systemic Antibiotic Therapy in the Treatment of Peri-Implantitis

Toledano-Osorio

Vallecillo

Toledano³

et al. 2022

IJERPH

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“…Both of these antimicrobial techniques were adjunctive to MD. Based on the obtained results, the authors concluded that aPDT was also effective in reducing severe peri‐implant symptoms compared with conventional antimicrobial therapy and could be used as an adjunctive approach (33). It is important to emphasize that aPDT as a complimentary technique seems to provide better results than single therapies (34–36).…”

Section: Mechanisms Involved In Disinfection and Biomodulation Outcomes Promoted By Antimicrobial Photodynamic Therapy (Apdt) In Implant mentioning

confidence: 99%

Antimicrobial Photodynamic Therapy (aPDT) as a Disinfection and Biomodulation Approach in Implant Dentistry

Rastelli

2021

Photochem & Photobiology

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This article is a highlight of the paper by Choe et al. in this issue of Photochemistry and Photobiology. In that review paper, the disinfection and biomodulation outcomes promoted by antimicrobial photodynamic therapy (aPDT) on peri‐implantitis infection were stated and discussed. The killing of the oral pathogens by aPDT is based on the generation of reactive oxygen species (ROS). Besides that, biomodulation can also be provided by aPDT and improve the healing and modulate the inflammatory process. Although aPDT has shown positive effects on the treatment of peri‐implantitis disease mainly as a complimentary technique, the authors suggested that more and standardize clinical studies are needed to support the clinical application of aPDT for that purpose. Also, the standardization of parameters related to the light source and photosensitizers is required. In addition, nano‐based materials may improve aPDT performance against oral biofilms and could increase the hopes of overcoming dental implant failures.

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“…aPDT, can eliminate the microorganisms in hard-to-reach areas not accessible in periodontal therapy. Thus, it may be used as an alternative for the treatment of periodontitis and peri-implantitis (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Effect of Photodynamic Therapy with Indocyanine Green Followed by 660 nm Photobiomodulation Therapy on Fibroblast Viability

Etemadi

Imani

Jafari

et al. 2021

Photochem & Photobiology

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This in vitro study sought to assess the effect of repetitive PBMT on the viability of fibroblasts following aPDT with indocyanine green (ICG). In this in vitro experimental study, human gingival fibroblasts (HGFs) were obtained and incubated in a culture medium. After reaching 10 000 cells cm À2 , the cells were divided into five groups of control, aPDT with ICG and 808 nm (energy density of 24 J cm À2 ), PBMT immediately after aPDT, PBMT with 660 nm (energy density of 7.2 J cm À2 ) immediately and 24 h after aPDT and PBMT immediately and 24 and 48 h after aPDT in 48-well plates. Cell viability was evaluated using the methyl thiazolyl tetrazolium (MTT) assay after 1, 4 and 7 days of incubation. Statistical analyses were performed using one-way ANOVA. Cell viability significantly decreased in group 2 (P < 0.002). We observed no significant increase in cell viability at any time point in group 3 (P > 0.05). Cell viability significantly increased in groups 4 and 5 after the first day of incubation (P < 0.000). Emission of 660 nm as PBMT for two and three times along with passage of time would increase the viability of HGFs following aPDT with ICG.

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Clinical efficacy of photodynamic therapy as an adjunct to mechanical debridement in the treatment of per-implantitis with abscess

Cited by 46 publications

References 27 publications

A Systematic Review and Meta-Analysis of Systemic Antibiotic Therapy in the Treatment of Peri-Implantitis

A Systematic Review and Meta-Analysis of Systemic Antibiotic Therapy in the Treatment of Peri-Implantitis

Antimicrobial Photodynamic Therapy (aPDT) as a Disinfection and Biomodulation Approach in Implant Dentistry

In Vitro Effect of Photodynamic Therapy with Indocyanine Green Followed by 660 nm Photobiomodulation Therapy on Fibroblast Viability

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