Clinical efficacy of spray‐based heat‐treated lactobacilli in canine atopic dermatitis: a preliminary, open‐label, uncontrolled study

Santoro, Domenico; Fagman, Lana; Zhang, Yanping; Yu, Fahong

doi:10.1111/vde.12915

Cited by 7 publications

(6 citation statements)

References 31 publications

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“…Canine atopic dermatitis (CAD) is an immunoinflammatory cutaneous disease that causes itching (pruritis), swollen spots, and elevated dark gray patches on the paws, neck, ear, mouth, tail, armpit, thighs, and other sites [1,2]. Several owners observed that dogs with CAD start rubbing against objects, scratching, and biting their feet [3]. The etiology of CAD is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

Adam

Park²,

Cho³

et al. 2022

Vet World

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Background and Aim: Canine atopic dermatitis (CAD) is a hereditary susceptibility to the development of allergic symptoms in response to repeated exposure to generally innocuous substances known as "allergens." Allergens can be plants, animals, mold, mites, or milk. At present, serological enzyme-linked immunoassay (ELISA) kits are used for immunoglobulin E (IgE)-specific allergen detection due to their simplicity and accuracy. This study aimed to detect allergens in dogs with CAD and determine how they differ according to season, breed, age, and sex using a serological test in six provinces in South Korea for 12 months. This will allow practitioners to easily understand the risk factors related to CAD. Materials and Methods: In this study, IgE allergen-specific ELISA kits were used. The allergens were detected in serum samples collected from different regions considering season, sex, breed, and age. Allergens were divided into the following Ten categories: 1. Dairy, yeast, and egg, 2. grains, 3. vegetables, 4. meat, 5. seafood, 6. animals, 7. mold, 8. insects, 9. mites, and 10. trees. Results: The percentage of allergens detected in males (54.8%) was higher than that of females (45.2%); 54.2% of allergens occurred in 3-year-old dogs or older. Moreover, regarding frequency, 65.6% of overall allergens occur during autumn; Chungcheongnam-do and Jeollabuk-do showed 20.7% and 20.9%, respectively. Additionally, among allergens categories, notable allergen occurrence was as follows: 38.3% corn; 28.7% potatoes; 22.7% duck; 24.4%,codfish; 31.2% animal wool; 95.6% Aspergillus fumigatus; 31.9% flea; 41.8% oak; and 25.0% sheep's sorrel grass. Conclusion: This study showcases the frequency of 60 allergens in six provinces detected in dogs with CAD; most likely from food or the environment using serological ELISA kits. Environmental sensitizer results can be considered for humans suffering from allergies to avoid a similar environment. A large-scale study can be performed to evaluate the allergens in the state. However, neither a skin test nor feed analysis was conducted, which is a limitation of this study.

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Section: Introductionmentioning

confidence: 99%

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

Adam

Park²,

Cho³

et al. 2022

Vet World

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“…At each assessment the owner's previous digital PVAS10 evaluation was prepopulated, as this has been recently demonstrated to lead to better agreement between owners' perceptions and changes in pruritus scores and is believed to improve scoring reliability and effectiveness [94]. While other studies regularly employ use of this scale [49,63,64,[95][96][97][98][99][100], to our knowledge none have shown the score from the previous assessment, and, more commonly, less reliable versions of visual analogue scales or numerical scales are employed [75,101]. Given that dogs representing mild pruritus (digital PVAS10 < 3.6) were enrolled, an appropriate outcome threshold is normal to very mild pruritus (digital PVAS10-N: <2) [76].…”

Section: Discussionmentioning

confidence: 99%

A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs

Tate,

Tanprasertsuk,

Jones

et al. 2024

Animals

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Pruritic dermatitis (PD) is a common presentation of canine allergic skin diseases, with diversity in severity and treatment response due to complex etiopathogenesis. Evidence suggests the gut microbiota (GM) may contribute to the development of canine allergies. A 10-week double-blind randomized controlled trial evaluated a novel probiotic and nutraceutical blend (PNB) on clinical signs of skin allergy, health measures, and the GM of privately owned self-reported pruritic dogs. A total of 105 dogs were enrolled, with 62 included in pruritus and health analysis and 50 in microbiome analysis. The PNB supported greater improvement of owner-assessed clinical signs of PD at week 2 than the placebo (PBO). More dogs that received the PNB shifted to normal pruritus (digital PVAS10-N: <2) by week 4, compared to week 7 for the PBO. While a placebo effect was identified, clinical differences were supported by changes in the GM. The PNB enriched three probiotic bacteria and reduced abundances of species associated with negative effects. The PBO group demonstrated increased abundances of pathogenic species and reduced abundances of several beneficial species. This trial supports the potential of the PNB as a supplemental intervention in the treatment of PD; however, further investigation is warranted, with stricter diagnostic criteria, disease biomarkers and direct veterinary examination.

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“…Comparatively, in cAD, TP corresponds to the treatment of flares, or "reactive therapy"; SP corresponds to the prevention of flares, or "proactive therapy"; and PP corresponds to strategies or interventions that are implemented to avoid the development of the disease altogether. However, while there is extensive research to develop and improve existing treatments [7,27,28,30,33,35,[39][40][41][42][43] and even to develop proactive strategies [21,44], cAD primary prevention is entirely neglected. Despite Marsella (2013) suggesting that skin barrier repair interventions could prove beneficial when initiated in early life in cAD's predisposed breeds [45], research on these strategies has not been pursued.…”

Section: What Is Prevention?mentioning

confidence: 99%

Primary Prevention of Canine Atopic Dermatitis: Breaking the Cycle—A Narrative Review

Fernandes,

Alves,

Schmidt

et al. 2023

Veterinary Sciences

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Canine atopic dermatitis (cAD) is a common and distressing skin condition in dogs, affecting up to 30% of the canine population. It not only impacts their quality of life but also that of their owners. Like human atopic dermatitis (hAD), cAD has a complex pathogenesis, including genetic and environmental factors. Current treatments focus on managing clinical signs, but they can be costly and have limitations. This article emphasizes the importance of preventing cAD from developing in the first place. Understanding the role of the skin’s protective barrier is crucial, as its dysfunction plays a vital role in both hAD and cAD. hAD prevention studies have shown promising results in enhancing the skin barrier, but more research is needed to support more robust conclusions. While hAD primary prevention is currently a focal point of intensive investigation in human medicine, research on cAD primary prevention remains under-researched and almost non-existent. Pioneering effective prevention strategies for cAD holds immense potential to enhance the quality of life for both dogs and their owners. Additionally, it bears the promise of a translational impact on human research. Hence, further exploration of this crucial topic is not only relevant but also timely and imperative, warranting support and encouragement.

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Clinical efficacy of spray‐based heat‐treated lactobacilli in canine atopic dermatitis: a preliminary, open‐label, uncontrolled study

Cited by 7 publications

References 31 publications

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs

Primary Prevention of Canine Atopic Dermatitis: Breaking the Cycle—A Narrative Review

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