Clinical Efficacy of Tacrolimus $\text{Ointment}+3\%$ Boric Acid Lotion Joint Chinese Angelica Decoction in Chronic Perianal Eczema

Abstract

Objective. To unearth the clinical efficacy of tacrolimus ointment + 3 % boric acid lotion joint Chinese angelica decoction in chronic perianal eczema. Methods. Patients with chronic perianal eczema admitted to hospital from June 2018 and June 2019 were retrospectively analyzed. Patients in the control group ( n = 38 ) underwent basic therapy with tacrolimus ointment + 3 % boric acid lotion, whereas those in the observation group ( n = 38 ) were given oral Chinese angelica decoction on the basis of the above therapy. Patient’s baseline information before therapy and clinical symptoms after therapy were observed and compared, including pruritus ani score, anus drainage and damp score, skin lesion score, skin lesion area score, life quality index score, and IL-2, IL-4, and IgE levels in serum. Overall efficacy in the two groups was also evaluated. Results. No significant differences were found in the baseline information between the observation group and control group before therapy. After therapy, pruritus ani score ( P = 0.023 ), anus drainage and damp score ( P = 0.041 ), skin lesion score ( P = 0.025 ), and skin lesion area score ( P = 0.035 ) of patients in the observation group were remarkably lower than those in the control group. Significantly higher release levels of clinical symptoms of patients in the observation group were indicated. With respect to the control group, the life quality score ( P = 0.020 ) and IgE level in serum ( P = 0.003 ) of patients in the observation group were significantly lower, while IL-4 level in serum was significantly higher ( P = 0.129 ). The therapy in the observation group achieved better clinical efficacy. Overall efficacy in the observation group was markedly favorable with respect to the control group. Conclusion. With respect to tacrolimus ointment + 3 % boric acid lotion, patients with chronic perianal eczema displayed better clinical efficacy after jointly being treated by Chinese angelica decoction.

Computational Screening of the Natural Product Osthole and Its Derivates for Anti-Inflammatory Activity

“…We modified this group by removing the methyl (protonated: 1, deprotonated: 2) and also modified the 7th position with a phenoxy (3) group and with three triazoles containing aromatic and heteroaromatic methoxy groups (4)(5)(6). Furthermore, we modified the OS compound at the 4th position, adding various electron-withdrawing groups, such as -CN (7) and -CF3 (8), and heteroaromatic and aromatic rings (9 and 10). In addition to these derivatives, we performed double modifications at the 6th and 5th positions using methoxy groups (11 and 14) and also used a chiral cyclic ring structure at the 6-7th position (12 and 13).…”

“…(4)(5)(6). The modifications at 4th positions are electron-withdrawing cyano (7), trifluoro (8), and aromatic and heteroaromatic functionalities. The other modifications include at 6th and 5th position (11 and 14), and a chiral cyclic ring structure at 6-7th position (12 and 13).…”

“…Novel computational methods have opened up new possibilities for processing complex natural products and using their derivates to develop novel drugs [4]. Traditional Chinese medicine (TCM) and the Indian system of medicine (ISM) have been using the plants called Cnidium monnieri (L) Cusson [5,6], and Angelica archangelica Linn [7][8][9], respectively, for various disease conditions, such as itchy skin [10], eczema [7], erectile dysfunction [4,6,11], cancer [12], and osteoporosis [13][14][15][16], as well as fungal and bacterial infections [17,18]. Osthole (7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one) is a natural coumarin and a major chemical constituent in the above-mentioned plants [15,[17][18][19], and has been recognized as a promising lead compound in drug discovery research associated with various pharmacological activities, such as anti-cancer [19,20], anti-inflammatory [21][22][23], antioxidative [20,24], antiangiogenic activity [25], antiallergic [26][27][28], immunomodulation [27,29,30], and hepatoprotective activities [31][32][33][34][35].…”