Clinical efficacy of the 595 nm pulsed dye laser in the treatment of childhood superficial hemangioma – analysis of 10-year application in Chinese patients

Chen, Wei; Liu, Shengxiu; Yang, Chonglin; Yang, Sen

doi:10.3109/09546634.2013.806979

Cited by 15 publications

(19 citation statements)

References 15 publications

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“…But there is controversy about the role of PDL in the treatment of IH. We found that the 595 nm PDL can improve treatment efficiency in patients with superficial hemangiomas, with fewer side-effects [8]. 595 nm PDL has been used in our department for the treatment of skin vascular disease, mainly for IH and port wine stains, since 2005.…”

Section: Discussionmentioning

confidence: 85%

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Curative effect study of pulsed dye laser in the treatment of 43 patients with hand infantile hemangioma

Chen¹,

Yang²,

Liu³

et al. 2014

European Journal of Dermatology

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Curative effect study of pulsed dye laser in the treatment of 43 patients with hand infantile hemangiomaObjective: Pulsed dye laser has been proved to be fairly effective in the treatment of infantile hemangioma. But the effect varies in different body sites. The objective of this study was to assess the long-term outcome and complications of 595 nm pulsed dye laser in the treatment of hand infantile hemangioma in our laser department, retrospectively. Patients and Methods: The patients with hand infantile hemangioma who had received pulsed dye laser (595 nm V-beam, Candela Cop., Wayland, MA. Parameters: fluence 10∼13 J/cm 2 , pulse duration 20∼40 ms, spot diameter 7 mm, epidermal cooling 20/40 s) treatment in past 5 years were recruited for the study. Detailed demographics, results of questionnaires and clinical examination were entered into a database and statistical analyses were conducted where applicable. Results: 43 patients with hand infantile hemangioma were recruited, including 29 females and 14 males, with a mean age of 8.92 months at treatment time. 7 patients with 10 hemangioma lesions at other sites from the hand meanwhile received laser treatment. There was a significant difference in the subjective assessment of clearing between hand lesions and additional other site hemangioma (p<0.001). The average Patient Satisfaction Score was 7.25 for hand hemangioma, the average Patient Satisfaction Score was 4.45 for other site hemangioma lesions, there was a significant difference between hand and non-hand lesions (p<0.001). Conclusions: 595 nm pulsed dye laser provides a safe and effective modality with lower morbidity for hand hemangioma.

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Section: Discussionmentioning

confidence: 85%

“…Michel [10] and Witman et al [11] reported that the majority of hemangiomas had different side-effects after PDL treatment but these side-effects could be tolerated in our limited databases [8]. Many documents have reported side-effects arising in patients with hemangioma treated by PDL.…”

Section: Discussionmentioning

confidence: 93%

Curative effect study of pulsed dye laser in the treatment of 43 patients with hand infantile hemangioma

Chen¹,

Yang²,

Liu³

et al. 2014

European Journal of Dermatology

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“…). Among 153 publications included in the full review, 29 studies addressed lasers: 12 comparative studies (4 RCTs, reported in multiple publications, of good and fair quality and 8 retrospective cohort studies of fair and poor quality ) and 17 case series (1 good , 2 fair , and 14 poor quality for harms reporting ). Most studies included children with IH in multiple locations; one included children with only airway IH and another with hand IH .…”

Section: Resultsmentioning

confidence: 99%

“…Two cohort studies compared PDL with adjunctive β‐blockers and with β‐blockers alone . Case series reported harms associated with PDL , Nd:YAG lasers , combined PDL and Nd:YAG , long‐pulse Alexandrite laser , and CO 2 laser . Table outlines key study outcomes.…”

Section: Resultsmentioning

confidence: 99%

Laser treatment of infantile hemangioma: A systematic review

2015

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Studies of laser treatment of IH primarily addressed different laser modalities compared with observation or other laser modalities. PDL was the most commonly studied laser type, but multiple variations in treatment protocols did not allow for demonstration of superiority of a single method. Most studies reported a higher success rate with longer pulse PDL compared to observation in managing the size of IH, although the magnitude of effect differed substantially. Studies generally found PDL more effective than other types of lasers for cutaneous lesions. When first introduced as a primary treatment for IH, various laser modalities generally offered superior outcomes compared with steroid therapy and observation. In the era of β-blocker therapy, laser treatment may retain an important role in the treatment of residual and refractory lesions.

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“…As the leading effective laser treatment for IH, PDL works through selective photothermolysis to prevent enlargement and promote involution of IH [25,26]. Instead of waiting passively for natural regression that may take a long time and even lead to suboptimal cosmetic results and psychosocial distress despite later intervention, the high safety profile of topical timolol and/or PDL presents a splendid opportunity to actively intervene early, safely, and nonsystemically with a higher likelihood of earlier and complete regression [10,12,[27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Novel Combination Topical Timolol and Pulsed Dye Laser Therapy for Early Effective Safe Treatment of Infantile Hemangiomas

Chang¹,

Kang²

2017

J Clin Exp Dermatol Res

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Introduction: Infantile Hemangiomas (IH) are the most common benign pediatric tumors and carry potential cosmetic and functional sequelae. Topical timolol and Pulsed Dye Laser (PDL) are effective IH therapies and previous studies have suggested the superiority of combination timolol-PDL therapy for IH over timolol alone. We present our experience using combination timolol and PDL therapy for IH, postulate a synergistic effect, and analyze the impact of age on outcomes.

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Clinical efficacy of the 595 nm pulsed dye laser in the treatment of childhood superficial hemangioma – analysis of 10-year application in Chinese patients

Abstract: Our experience confirmed the satisfactory clinical efficacy and safety of the 595 nm tunable pulse dye laser in the treatment of childhood superficial hemangioma.

Cited by 15 publications

References 15 publications

Curative effect study of pulsed dye laser in the treatment of 43 patients with hand infantile hemangioma

Curative effect study of pulsed dye laser in the treatment of 43 patients with hand infantile hemangioma

Laser treatment of infantile hemangioma: A systematic review

Novel Combination Topical Timolol and Pulsed Dye Laser Therapy for Early Effective Safe Treatment of Infantile Hemangiomas

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