Clinical Efficacy of the GnRH Agonist (Deslorelin) in Dogs Affected by Benign Prostatic Hyperplasia and Evaluation of Prostatic Blood Flow by Doppler Ultrasound

Abstract

In six German Shepherds dogs, GnRH agonist implants (Deslorelin) were inserted subcutaneously one month after histological confirmation of benign prostatic hyperplasia (BPH). Prostatic volume (PV), characteristics of ejaculate, serum testosterone concentrations and Doppler parameters of prostatic and subcapsular arteries were detected at different time intervals, for 6 month. The prostatic volume showed a significantly reduction starting at day 37. The decrease in sperm concentration, motility and increase in morphological abnormal sperm were observed from day 22 to day 37, when it was no longer possible to obtain the ejaculate. The values of peak systolic velocity and end-diastolic velocity in prostatic and subcapsular arteries showed from day 11 a gradual decrease, significant at day 22 until day 37 and reaching the lowest values at day 52 until the end of observation. The power Doppler pixel intensity of both arteries showed a gradual decrease from day 5 until day 52. In particular, a significant decrease was observed for both arteries from day 11. Testosterone serum concentration decreased to undetectable levels by day 11 until the end of the observations. All these Doppler parameters and testosterone values were positively correlated with the prostatic volume. Furthermore, testosterone values were positively correlated with peak systolic velocity, end diastolic velocity and pixel numbers. The use of implants containing GnRH analogues, even in asymptomatic subjects, is effective for the control of BPH and the application of Doppler exam of prostatic blood flow represent an non-invasive tool for monitoring the response of medical treatment.

Two-dimensional and Doppler sonographic prostatic appearance of sexually intact French Bulldogs

“…There is evidence that the prostatic vascular system is a primary target of androgen action [35] and other evidence suggests that the regression of the prostatic parenchyma in treated dogs occurs secondarily to the regression of the prostatic vascular system through cell death mediated by tissue ischemia/hypoxia [33].…”

“…In men, the use of Doppler allows for the visualization of neoplastic [27] and hyperplastic changes [28] and for determining prognosis after surgical resection [29,30]. In dogs, the Doppler technique represents a valid noninvasive method for characterizing the blood flow in the prostatic artery in normal dogs [31], benign hyperplasia prostatic-affected dogs [7,32], and treated dogs [33]. The mean RI and PI obtained in the present study for the prostatic artery are similar to those found in the literature [6,7].…”

Pharmacological Treatment for Common Prostatic Conditions in Dogs – Benign Prostatic Hyperplasia and Prostatitis: an Update

“…Recently, colour Doppler blood flow indices indicating dog prostate perfusion after treatment with a 4.7 mg deslorelin implant were described and compared to initial, pre‐treatment values (Polisca et al. ) and values reported for BPH by Günzel‐Apel et al. ().…”

“…Recently, colour Doppler blood flow indices indicating dog prostate perfusion after treatment with a 4.7 mg deslorelin implant were described and compared to initial, pre-treatment values (Polisca et al 2013) and values reported for BPH by G€ unzel-Apel et al (2001). The systolic peak velocity (SPV) and end diastolic velocity (EDV) in prostatic and subcapsular arteries decreased gradually from day 11 after implant administration.…”

Androgen Deficiency and Progression of Benign Prostatic Hyperplasia in Patients With Metabolic Syndrome: Is There Any Controversy? (A Literature Review)

“…Это позволяет предполагать, что при андроген-ной недостаточности кровоснабжение ПЖ может ухуд-шаться. Подтверждением этому являются данные, сви-детельствующие, что при ингибировании синтеза тестостерона введением агониста гонадотропин-рили-зинг-гормона деслорелина собакам наряду со снижени-ем его концентрации в крови регистрировали ухудшение кровоснабжения гиперплазированной железы, оцененное допплерографией простатических и субкапсулярных ар-терий и картированием ПЖ [44]. В клиническом иссле-довании О. Б. Жуков и соавт.…”