Clinical efficacy of treatment for primary tracheal tumors by flexible bronchoscopy: Airway stenosis recanalization and quality of life

Abstract

The aim of the present study was to evaluate the effectiveness of interventional treatment of primary tracheal tumors through flexible bronchoscopy. The clinical data of 38 patients with primary tracheal tumours who underwent flexible bronchoscopy intervention therapy between January 2011 and January 2017 were retrospectively analyzed. The average time interval from onset of symptoms to the appearance of actual clinical manifestations in the 38 patients ranged from 0 to 60 months, with an average of 8.1±11.6 months and a median of 4.2 months. The rate of misdiagnosis at the first visit was 36.8% (14/38). After interventional treatment, the overall efficiency (complete + partial response) of airway stenosis recanalization in the 38 patients was 89.5%. In 3 patients with benign tumors, the anhelation score was reduced following treatment (1.00±0.77 vs. 3.13±1.21 at the pre-treatment stage; P<0.001). The overall survival rates of the 35 patients at 1, 3 and 5 years were 69.3, 48.7 and 20.3%, respectively. Therefore, flexible bronchoscopic intervention may effectively smoothen the airways of patients and relieve the symptoms of anhelation. Combining radiotherapy and chemotherapy may improve patient prognosis and safety.

Endoscopic Excision of Primary Tracheal Schwannoma: A Case Report

“…The criterion standard management of tracheal schwannoma is open surgical tracheal resection with end-to-end anastomosis. APPROVED GALLEY PROOF However, it is not suitable for long segmental tracheal resection [17]. Reports of the use of endoscopic excision of this tumor have increased in recent literature [3].…”

“…However, it is not suitable for long segmental tracheal resection [ 17 ]. Reports of the use of endoscopic excision of this tumor have increased in recent literature [ 3 ].…”

Molecular Features of a Primary Transmural Tracheal Schwannoma: Clinical Experience and Review of the Literature

“…However, it is not suitable for long segmental tracheal resection, owing to the lack of an ideal material for a tracheal substitute. 1 Alternative treatment consists of a complete endoscopic approach, especially in patients whose tumors were pedunculated-type and intraluminal. 10 Of note, there were some cases of tumor local recurrence after endoscopic resection, 5 , 8 , 11 whereas no relapse was recorded in surgical resection.…”

“…Primary tracheal tumor is an uncommon disease, with an estimated incidence of one case per million. 1 The majority of these neoplasms are malignancies and mostly consists of squamous cell carcinoma and adenoid cystic carcinoma. 2 Primary tracheal neurogenic tumors are extremely rare, constituting less than 0.5% of primary tracheal tumors.…”

Central airway obstruction from lymphomatoid granulomatosis treated with an endobronchial stent

“…Five-year survival rates of malignant tracheal tumors in non-surgically and surgically treated patients are 10% and 50%, respectively. A retrospective study focused on multiple primary tracheal tumors showed that 90% of cases were recanalized with the use of multiple bronchoscopy procedures leading to significant dyspnea improvement [ 8 ].…”