Clinical-endoscopic relevance of incidental colorectal lesions detected by PET-CT

Durán, Carmen Garrido; Capo, M. A.; Caparrós, Carmen García; García, Marta Giménez; Domenech, J.

doi:10.17235/reed.2018.4719/2016

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Several patients presented with more than one lesion during colonoscopy. Every attempt was made to explore findings at the PET with the localization at colonoscopy, which is also described in the literature [30]. We did not explore the association of the anatomical location of the PET-avid lesions with individual findings on colonoscopy and the final pathological reference.…”

Section: Discussionmentioning

confidence: 99%

Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients

et al. 2020

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Background and study aims Further diagnostics of incidental colorectal lesions on 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is questionable. Therefore, we aimed to evaluate the clinical importance of incidentally detected colorectal lesions on FDG-PET/CT. Patients and methods In the North Denmark Region, a retrospective study was performed among 19,987 patients who had an FDG-PET/CT from January 2006 to December 2015. Among these patients, we identified patients with a colonoscopy within 12 months from the PET/CT scan and a description of incidental colorectal PET-avid lesions on the PET/CT. PET findings were compared with colonoscopy-detected lesions and eventually histopathology. Results Incidental PET-avid lesions were observed in 549 patients. Colonoscopy revealed lesions in 457 (83 %), among whom 338 patients had a final histopathological diagnosis. Malignant and premalignant lesions were found in 297 patients (54 % among patients with a PET-avid lesion). The lesions were cancer in 76 patients and adenoma in 221 patients of whom 30 had high-grade and 191 low-grade adenomas. The findings changed patient management in 166 cases (30 % of all patients with a PET-avid lesion). A colonoscopy-based surveillance program was initiated for 80 % of patients with high-grade adenoma. No patients with PET-avid lesions but normal colonoscopy developed colorectal cancer during 3 years of observation (median observation time 7 years). Conclusions Incidental colorectal FDG uptake was infrequently observed, but when present, it was associated with a high rate of malignant or premalignant lesions. Our results indicate that patients with incidental colorectal FDG uptake should be referred to diagnostic work-up including colonoscopy.

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Section: Discussionmentioning

confidence: 99%

Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients

et al. 2020

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“…Gutman et al reported that 15 of 20 patients with focal colonic FDG uptake had positive endoscopic findings. 10 van Hoeij et al, 11 Treglia et al, 7 Garrido Durán et al 12 and Putora et al 13 reported a PPV of 62% to 86%. In view of the high likelihood of identifying a polypoid lesion, our study supports previous suggestions of performing endoscopy for further investigations of incidental focal colonic activity.…”

Section: Discussionmentioning

confidence: 99%

Incidental Focal Colonic Uptake of 18F-fluorodeoxyglucose on Positron Emission Tomography/Computed Tomography: Its Incidence and Clinical Significance

Hui

Kung

Yong

2020

Hong Kong Journal of Radiology

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“…Incidental FDG uptake was found in 3.6% of patients in PET/CT evaluations for non-GI system diseases 8 . However, false positive involvements were detected in 9.3–63% of patients, emphasizing the need to interpret PET/CT results 9 carefully.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of patients via colonoscopy who underwent positron emission tomography/computerized tomography due to colon involvement

Ekmen,

Aksoy

2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: Fluorodeoxyglucose is not a tumor-specific agent and it can also be involved in benign conditions, which may cause diagnostic confusion. This research aims to elucidate the colonoscopic findings of patients who underwent colonoscopy due to colon involvement in positron emission tomography/computerized tomography. METHODS: A total of 71 patients who underwent colonoscopy due to colonic involvement in positron emission tomography/computerized tomography at SBU Keçiören Training and Research Hospital Gastroenterology Clinic Endoscopy Unit have been analyzed retrospectively. Demographic characteristics of the patients, areas of involvement in positron emission tomography/computerized tomography, and severity have been obtained from the hospital database. RESULTS: The gastrointestinal involvement area of 22.5% (n=16) of the patients was ascending colon, 15.5% (n=11) was sigmoid, 15.5% (n=11) was rectum, 12.7% (n=9) was stomach, 11.3% (n=8) was transverse colon, 8.5% (n=6) was anal canal, 5.6% (n=4) was esophagus, and 5.6% (n=4) was descending colon. The endoscopic findings of 19.7% (n=14) patients were normal, whereas 29.6% (n=21) had polyps, 9.9% (n=7) had cancer, 2.8% (n=2) had an ulcer, 15.5% (n=11) had gastritis, 14.1% (n=10) had hemorrhoids, and 7% (n=5) had colitis. CONCLUSION: Fluorodeoxyglucose-positron emission tomography can detect unexpected distant metastases with high sensitivity because it allows whole-body imaging. Curative resection significantly contributes to the choice of treatment modality in the pre-operative period of colorectal cancer patients with planned surgery.

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Clinical-endoscopic relevance of incidental colorectal lesions detected by PET-CT

Abstract: there is a good correlation between the findings identified by PET-CT and the endoscopic study. In our study, a SUVmax > 11 g/ml suggests a malignant pathology, which aids the prioritization of an endoscopic study.

Cited by 6 publications

References 19 publications

Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients

Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients

Incidental Focal Colonic Uptake of 18F-fluorodeoxyglucose on Positron Emission Tomography/Computed Tomography: Its Incidence and Clinical Significance

Evaluation of patients via colonoscopy who underwent positron emission tomography/computerized tomography due to colon involvement

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