Clinical epidemiology of adenovirus pneumonia among Chinese hospitalized children

Tian, Jiao; Wang, Xinyu; Li, Qi; Zhang, Linlin; Ai, Junhong; Feng, Guoshuang; Zeng, Yueping; Wang, Ran; Xie, Zhengde

doi:10.1007/s00203-024-03870-3

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…In conclusion, considering the economic burden and health threats posed by adenovirus pneumonia, delving into its mechanisms holds profound significance ( 43 ). This study reveals a novel regulatory mechanism involving the 100 kDa protein encoded by HAdV-7 in the activation of the NLRP3 inflammasome.…”

Section: Discussionmentioning

confidence: 99%

Activation of the NLRP3 inflammasome by human adenovirus type 7 L4 100-kilodalton protein

Duan,

Zhu,

Zhang

et al. 2024

Front. Immunol.

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Human adenovirus type 7 (HAdV-7) is a significant viral pathogen that causes respiratory infections in children. Currently, there are no specific antiviral drugs or vaccines for children targeting HAdV-7, and the mechanisms of its pathogenesis remain unclear. The NLRP3 inflammasome-driven inflammatory cascade plays a crucial role in the host’s antiviral immunity. Our previous study demonstrated that HAdV-7 infection activates the NLRP3 inflammasome. Building upon this finding, our current study has identified the L4 100 kDa protein encoded by HAdV-7 as the primary viral component responsible for NLRP3 inflammasome activation. By utilizing techniques such as co-immunoprecipitation, we have confirmed that the 100 kDa protein interacts with the NLRP3 protein and facilitates the assembly of the NLRP3 inflammasome by binding specifically to the NACHT and LRR domains of NLRP3. These insights offer a deeper understanding of HAdV-7 pathogenesis and contribute to the development of novel antiviral therapies.

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Section: Discussionmentioning

confidence: 99%

Activation of the NLRP3 inflammasome by human adenovirus type 7 L4 100-kilodalton protein

Duan,

Zhu,

Zhang

et al. 2024

Front. Immunol.

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Risk factor analysis and prediction model construction for severe adenovirus pneumonia in children

Liang,

Wu,

Chen

et al. 2024

Ital J Pediatr

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Background Severe adenovirus pneumonia in children has a high mortality rate, but research on risk prediction models is lacking. Such models are essential as they allow individualized predictions and assess whether children will likely progress to severe disease. Methods A retrospective analysis was performed on children with adenovirus pneumonia who were hospitalized at the Children’s Hospital of Nanjing Medical University from January 2017 to March 2024. The patients were grouped according to clinical factors, and the groups were compared using Ridge regression and multiple logistic regression to identify risk factors associated with severe adenovirus pneumonia. A prediction model was constructed, and its value in clinical application was evaluated. Results 699 patients were included in the study, with 284 in the severe group and 415 in the general group. Through the screening of 44 variables, the final risk factors for severe adenovirus pneumonia in children as the levels of neutrophils (OR = 1.086, 95% CI: 1.054‒1.119, P < 0.001), D-dimer (OR = 1.005, 95% CI: 1.003‒1.007, P < 0.001), fibrinogen degradation products (OR = 1.341, 95% CI: 1.034‒1.738, P = 0.027), B cells (OR = 1.076, 95%CI: 1.046‒1.107, P < 0.001), and lactate dehydrogenase (OR = 1.008, 95% CI: 1.005‒1.011, P < 0.001). The value of the area under the receiver operating characteristic curve was 0.974, the 95% CI was 0.963–0.985, and the P-value of the Hosmer-Lemeshow test was 0.547 (P > 0.05), indicating that the model had strong predictive power. Conclusion In this study, the clinical variables of children with adenovirus pneumonia were retrospectively analyzed to identify risk factors for severe disease. A prediction model for severe disease was constructed and evaluated, showing good application value.

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Clinical epidemiology of adenovirus pneumonia among Chinese hospitalized children

Cited by 2 publications

References 29 publications

Activation of the NLRP3 inflammasome by human adenovirus type 7 L4 100-kilodalton protein

Activation of the NLRP3 inflammasome by human adenovirus type 7 L4 100-kilodalton protein

Risk factor analysis and prediction model construction for severe adenovirus pneumonia in children

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