Objective: To measure space closure during the retraction of upper permanent canines with selfligating and conventional brackets. Materials and Methods: Fifteen patients who required maxillary canine retraction into first premolar extraction sites as part of their orthodontic treatment completed this study. In a random split-mouth design, the retraction of upper canines was performed using an elastomeric chain with 150 g of force. The evaluations were performed in dental casts (T0, initial; T1, 4 weeks; T2, 8 weeks; T3, 12 weeks). The amount of movement and the rotation of the canines as well as anchorage loss of the upper first molars were evaluated. Results: There was no difference between self-ligating and conventional brackets regarding the distal movement of upper canines and mesial movement of first molars (P . .05). Rotation of the upper canines was minimized with self-ligating brackets (P , .05). Conclusion: Distal movement of the upper canines and anchorage loss of the first molars were similar with both conventional and self-ligating brackets. Rotation of the upper canines during sliding mechanics was minimized with self-ligating brackets. (Angle Orthod. 2011;81:292-297.)