Clinical evaluation of a nystatin pastille for treatment of denture-related oral candidiasis

Interventions for the Management of Denture Stomatitis: A Systematic Review and Meta‐Analysis

“…Articles that did not mention any blinding of participants or personnel or assessment of outcome or that clearly stated that they were not blinded were rated as being at high risk of bias. Eight studies were blinded to participants, personnel, and outcome assessment …”

Cleaning removable orthodontic appliances — a survey

“…For example, Candida rapidly re -establishes itself in patients wearing removable prostheses after local anti-infective therapy for stomatitis. This may be at least partially due to microorganisms remaining in the acrylic [3,10].…”

“…Zum einen soll dadurch das Risiko für Karies, candidaassoziierte Stomatitis und Halitosis reduziert werden, andererseits soll, insbesondere bei Patienten mit eingeschränkter Immunabwehr, eine mögliche (Re-)Infektion durch die HKA vermieden werden. So zeigt sich beispielsweise bei Prothesenträgern mit Stomatitis nach Beendigung einer lokalen antiinfektiven Therapie häufig eine schnelle Candida-Reetablierung, was vermutlich unter anderem auf die im Kunststoff verbleibenden Mikroorganismen zurückzuführen ist [3,10].…”

Conventional and alternative antifungal therapies to oral candidiasis

“…Reasons for the use of nystatin over other drugs in the treatment of fungal denture stomatitis still remain: Johnson et al (23) in a clinical study showed nystatin (pastille) to be effective in reducing or eliminating the Candida organism associated with denture stomatitis; Truhlar et al . (53) showed that antifungal activity of nystatin in liners decreased with time, and that in vitro fungicidal activity was proportional to the concentration of nystatin administrated.…”