Clinical Evaluation of an Enamel Matrix Protein Derivative Combined With a Bioactive Glass for the Treatment of Intrabony Periodontal Defects in Humans

Sculean, Anton; Barbé, Giovanni; Chiantella, Giovanni Carlo; Arweiler, Nicole Birgit; Berakdar, Mohammad; Brecx, M

doi:10.1902/jop.2002.73.4.401

Cited by 135 publications

(191 citation statements)

References 35 publications

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“…3,4,5,32 The positive results of the control group (ABBM alone) are in accordance with findings from previous studies which had failed to show significant differences between treatment with ABBM alone or combinations of ABBM with enamel matrix derivative or platelet-rich plasma (PRP). 30,39 Although the results of this study suggest that treatment with ABBM-PRF may not have provided significantly better results than those obtained with ABBM alone, the possibility for PRF to show any beneficial effects over the control group might have been masked by the fact that treatment with ABBM alone resulted in significant improvement.…”

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confidence: 71%

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intra-bony defects. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with a simplified technique. Although certain studies have reported the use of PRF in the treatment of intra-bony defects, to date, none of them have evaluated its additive effects with ABBM. Therefore, a randomised, split-mouth clinical trial was conducted to compare healing of intra-bony defects treated with an ABBM-PRF combination with healing of those treated with ABBM alone. By using a split-mouth design, 15 paired intra-bony defects were randomly treated with either ABBM alone (control group) or ABBM-PRF combination (test group). Following clinical parameters and radiographical measurements were recorded at baseline and 6 months after treatment: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, depth of defect and defect angle. Preoperative clinical and radiographical measurements were similar for the test and control groups. Statistically significant reductions in GI, PD, CAL, vertical bone loss, depth of intra-bony defect and widening of defect angle were detected after treatment in both groups. With respect to inter-group analysis, gain in CAL was significantly greater in the test group than in the control group, whereas no inter-group differences were observed in any other parameter. The results of this study indicate that both therapies are effective in the treatment of intra-bony defects.

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confidence: 71%

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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“…The results of clinical studies [15][16][17] , however, appear to contradict this proposition. In many clinical studies [18][19][20] , patients were treated using larger size β-TCP particles, with clearly more favorable results in terms of periodontal regeneration. To our knowledge, a direct comparison of the 2 types of β-TCP particle in combination with PDGF-BB in histologic study of the treatment of periodontal defects is lacking.…”

Section: Introductionmentioning

confidence: 99%

Effect of β tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog

Irokawa¹,

Ota²,

Yamamoto³

et al. 2010

Dent. Mater. J.

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The aim of this study was to investigate the effect of β tricalcium phosphate (β-TCP) particle size on recombinant human plateletderived growth factor-BB (rhPDGF-BB)-induced regeneration of periodontal tissue in dog. The control group (rhPDGF-BB alone) was characterized by incomplete, newly formed bone. The large-particle β-TCP (L-TCP(O))/rhPDGF-BB group showed a statistically significant increase in both new bone and cementum formation compared to the small-particle β-TCP (S-TCP(G))/rhPDGF-BB group. These findings suggest that L-TCP(O)-particle promotes rhPDGF-BB-induced formation of bone and cementum.

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“…22 There are some studies that investigated the outcomes of Bio-Oss and Emdogain combination. 23 On the other hand, Biocorall is a natural xenograft that has been investigated both experimentally and clinically. 24,25 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Bone Repair Capacity and the Cytotoxic Properties of a Particular Xenograft: An Experimental Study in Rats

Saraydın¹,

Develıoğlu²

2011

Turkiye Klinikleri J Med Sci

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one repair is a major challenge for reconstructive surgery. The reconstruction of segmental mandibular defects following trauma or ablative surgery remains controversial because no single method results in the replacement of tissue that precisely matches the quantitiy or structural qualities of autogenous mandibular bone. Moreover, current A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Bo ne grafts ha ve be en wi dely used in os se o us de fects in me di ci ne and dentistry (e.g. pe ri o don to logy, imp lan to logy). This study aims to as sess bo ne and tis su e res pon se to a xe nog raft (Uni lab Sur gi bo ne) af ter the first and third month of imp lan ta ti on and its cyto to xi city in vit ro. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Fif te en rats, each of which ha ving a 5 mm cri ti cal-si ze, symmet ri cal, cir cu lar de fects in the cor pus of the man dib le we re rec ru i ted. The ex pe ri men tal de fects we re fil led with the bi o ma te ri al whe re as de fects on the op po si te si de we re used as con trols (sham-ope ra ted gro up). Af ter his to lo gi cal fol low-up, se ri al sec ti ons we re pre pa red for eva lu a ti on un der light micros co pe. The cyto to xi city of xe nog raft was exa mi ned in vit ro. R Re e s su ul lt t: : Xe nog rafts did not show any cyto to xi city for the cells. The re was no cal lus for ma ti on in the imp lan ta ti on si te at the first and third months, and Uni lab Sur gi bo ne ma te ri al was sur ro un ded with fib ro us tis su e. Den se col la geno us tis su e was ob ser ved in the con trol si te at the first and third months. C Co on nc c l lu u s si i o on n: : Alt ho ugh there was no evi den ce of bo ne bu il ding, the bi o ma te ri al se ems bi o com pa tib le and can be con si de red as a spa ce fil ler for such app li ca ti ons in den tistry.K Ke ey y W Wo or rd ds s: : Bo ne and bo nes; cyto to xi city tests, immu no lo gic; den tal prost he sis re pa ir; os te o ge ne sis Ö ÖZ ZE ET T A Am ma aç ç: : Ke mik greft ler ke mik de fekt le rin de tıp ve diş he kim li ğin de yay gın ola rak kul la nıl -mak ta dır (ör ne ğin pe ri o don to lo ji, imp lan to lo ji). Bu ça lış ma bir xe nog raf ta (Uni lab Sur gi bo ne) imp lan tas yon dan son ra ki birinci ve üçüncü ay da ke mik ve do ku ya nı tı nı de ğer len dir me yi amaç -la mak ta dır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Man di bu la kor pu sun da 5 mm kri tik bo yut lu si met rik da i re sel defekt le re sa hip 15 sı çan ça lış ma ya alın mış tır. Ça lış ma ya esas de fekt ler bi yo ma ter yal ile dol du ru lurken, kar şı ta raf ta ki de fekt ler kon trol ola rak kul la nıl dı. His to lo jik ta kip son ra sın da, ışık mik ros ko bu al tın da de ğer len dir me için se ri ke sit ler ha zır lan dı. Xe nog raft si to tok si si te si in vit ro in ce len di. B Bu ul l--g gu u l la ar r: : Xe nog raft lar hüc re ler için her han gi bir si to tok si si te gös ter me di. İmp lan tas yon ala nın da birinci ve üçüncü ay da kal lus oluş ma dı, ve Uni lab Sur gi ...

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Clinical Evaluation of an Enamel Matrix Protein Derivative Combined With a Bioactive Glass for the Treatment of Intrabony Periodontal Defects in Humans

Cited by 135 publications

References 35 publications

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

Effect of β tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog

Evaluation of the Bone Repair Capacity and the Cytotoxic Properties of a Particular Xenograft: An Experimental Study in Rats

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