Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study

Shao, Yanxiong; Zhou, Huaiyu

doi:10.1080/09546634.2019.1610548

Cited by 29 publications

(43 citation statements)

References 19 publications

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“…Chitosan mouthwash (0.5%) reduced aphthous stomatitis pain and ulcer size, exhibiting comparable performance to Triamcinolone, a corticosteroid product [165]. Similar results could also be achieved by using a mucoadhesive film [166]. Dental surgery clinical trials also found chitosanbased wound treatments to significantly shorten bleeding time and improve wound healing for patients undergoing minor surgery and tooth extractions [167,168].…”

Section: Human Clinical Trials Utilizing Chitin and Chitosan For Wounmentioning

confidence: 87%

“…Human clinical trials utilizing commercially available and custom-made chitin and chitosan wound treatments, resulting in significant improvements in the healing of ear, nasal, oral, and skin wounds, in addition to treatment of ulcers and serious hemorrhages. Data from [162][163][164][165][166][167][168][169][170][171][172][173][174][175][176][177]. Chitosan, unknown [177] These wound treatments have experienced significant success in oral clinical trials where they have been used to treat aphthous stomatitis (mouth ulcers), postoperative and tooth extraction wounds.…”

Section: Human Clinical Trials Utilizing Chitin and Chitosan For Wounmentioning

confidence: 99%

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Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

et al. 2020

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Chitin and its derivative chitosan are popular constituents in wound-treatment technologies due to their nanoscale fibrous morphology and attractive biomedical properties that accelerate healing and reduce scarring. These abundant natural polymers found in arthropod exoskeletons and fungal cell walls affect almost every phase of the healing process, acting as hemostatic and antibacterial agents that also support cell proliferation and attachment. However, key differences exist in the structure, properties, processing, and associated polymers of fungal and arthropod chitin, affecting their respective application to wound treatment. High purity crustacean-derived chitin and chitosan have been widely investigated for wound-treatment applications, with research incorporating chemically modified chitosan derivatives and advanced nanocomposite dressings utilizing biocompatible additives, such as natural polysaccharides, mineral clays, and metal nanoparticles used to achieve excellent mechanical and biomedical properties. Conversely, fungi-derived chitin is covalently decorated with -glucan and has received less research interest despite its mass production potential, simple extraction process, variations in chitin and associated polymer content, and the established healing properties of fungal exopolysaccharides. This review investigates the proven biomedical properties of both fungal- and crustacean-derived chitin and chitosan, their healing mechanisms, and their potential to advance modern wound-treatment methods through further research and practical application.

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Section: Human Clinical Trials Utilizing Chitin and Chitosan For Wounmentioning

confidence: 87%

Section: Human Clinical Trials Utilizing Chitin and Chitosan For Wounmentioning

confidence: 99%

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

et al. 2020

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“…Yanxiong Shao and Haiwen Zhou showed that reduction in ulcer size in the treated group with a mucoadhesive film containing chitosan was significantly more than that of the control group but there was no significant difference in terms of pain score, reduction in pain score and ulcer size between two groups [35]. They presented chitosan as an effective agent to use in the oral mucoadhesive film for the healing of RAS.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of zinc sulfate mucoadhesive formulation on recurrent aphthous stomatitis: a randomized double-blind, placebo-controlled clinical trial

et al. 2020

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Background: Recurrent aphthous stomatitis (RAS) is a common lesion that affects the oral mucosa. There are several methods to treat RAS, including systemic and topical formulations. This study was conducted to evaluate the anti-inflammatory effect of topical zinc sulfate and its efficacy in the treatment of RAS. Methods: A double-blind randomized clinical trial was conducted on 46 patients with RAS. They were randomly assigned into two groups to receive a zinc sulfate mucoadhesive tablet or placebo for 7 days. The pain severity was measured at baseline and daily while the diameter of the lesion was measured at baseline and on days 3, 5, and 7. The obtained data were analyzed in SPSS V.16. Results: There was no significant difference in the mean diameter of lesions and pain at baseline between the two groups (P = 0.643 and P = 0.842, respectively). However, on the third, fifth, and seventh days of the study, the diameter of the lesion significantly reduced in the intervention group (P = 0.001) and the pain intensity became significantly different between groups from the fourth day of the study (P = 0.001). Conclusion: Zinc sulfate mucoadhesive tablet was effective in recovery and reducing the pain and diameter of the aphthous lesion and could be considered for the treatment of RAS. Trial registration: Evaluation of the effectiveness of zinc sulfate mucoadhesive tablet in the improvement of recurrent aphthous stomatitis (RAS), IRCT20151109024975N9.

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“…Zhang et al constructed a Matrine/CS bio-film with biodegradable chitosan as the carrier material, which displayed good antibacterial performance, biocompatibility, and anti-inflammatory properties during healing of the aphtha (Zhang C. et al, 2019). The clinical trial results of Shao et al showed that chitosan can effectively promote drug penetration, robustly adheres to oral mucosa epithelial cells, has a strong curative effect, and can be applied as an excellent medicine for treating oral ulcerative lesions (Shao and Zhou, 2019).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Healing and Antimicrobial Efficacy of Chitosan-g-Polyacrylamide in a Rat Model of Gingival Ulcers

Zheng

Yin

et al. 2020

Front. Chem.

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Patients in dental hospitals often experience oral ulcerative lesions, which lead to pain and affect the patient's quality of life. At present, the goal of treating oral ulcerative lesions with drugs is to reduce inflammation and promote ulcer healing. However, very few antibacterial and hemostatic drugs are designed to be suitable for the microenvironment of gingival ulcers. Based on this, we have designed a natural therapeutic agent for oral ulcerative lesions that meets the various requirements of oral ulcerative lesion medication. The chitosan-g-polyacrylamide (CP) copolymer is composed of chitosan as the main chain and polyacrylamide polymers as the side chains. Antibacterial experiments show that this polymer can effectively inhibit the proliferation of Gram-negative (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). In vitro cell experiments also show that the CP copolymer is non-toxic, which is conducive to ulcer wound healing. Coagulation experiments prove that the CP copolymer can accelerate blood coagulation to stop bleeding. In experiments using a Wistar rat gingival ulcer model, the CP copolymer significantly promoted ulcer healing and shortened the healing time. These results indicate that the CP copolymer may serve as a potential therapeutic agent for oral ulcerative lesions.

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Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study

Cited by 29 publications

References 19 publications

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

Evaluation of zinc sulfate mucoadhesive formulation on recurrent aphthous stomatitis: a randomized double-blind, placebo-controlled clinical trial

Enhanced Healing and Antimicrobial Efficacy of Chitosan-g-Polyacrylamide in a Rat Model of Gingival Ulcers

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