Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Abstract

Introduction Vitamins C, E, and A and substances of plant origin, including azelaic acid and phytic acid are frequently used in cosmetic preparations to counteract oxidative stress and negative effects of free radicals. The aim of the study was to evaluate a novel combined therapy consisting of azelaic acid, ascorbic acid, and phytic acid applied layer on layer. Methods Twenty study participants received a series of eight treatments performed every 7 days. Twenty percent azelaic acid and then 30% phytic acid were applied to the entire face, while 40% l‐ascorbic acid only on the left side. The preparations were applied layer by layer. Skin parameters were measured before the series of treatments (T0), after the series of eight treatments (T1–8 weeks), and 1 month after the end of the treatment (T2–12 weeks). Results The application of two and three active compounds resulted in a significant improvement in erythema and hyperpigmentation both on the forehead and the cheeks, however, more pronounced effects were observed when all the three active compounds were used. Both applied types of treatment considerably increased skin moisture. All the participants (100%) were satisfied with the effects of the treatment. A majority of them reported an improvement in skin hydration, firmness, and elasticity, more uniform skin tone and a reduction of skin redness and wrinkles. Conclusions Topical application of these active compounds resulted in improvement of skin elasticity and flexibility, reduction of wrinkles, hyperpigmentation, erythema, and telangiectasia as well as amelioration of skin tone.

A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging

“…No studies on azelaic acid and skin aging met the inclusion criteria. While there are a handful of published studies investigating the use of azelaic acid in conjunction with other ingredients, for example, a 2022 study wherein three active compounds resulted in a significant improvement in erythema and hyperpigmentation, 57 none are RCTs and no studies have been conducted on the use of azelaic acid as a monotherapy in skin aging.…”

FG-4592 relieves diabetic kidney disease severity by influencing metabolic profiles via gut microbiota reconstruction in both human and mouse models

“…Furthermore, azelaic acid and chlorogenic acid are also reported to harbor antioxidant effects which are widely topically used in acne and other inflammatory skin diseases ( Markiewicz-Tomczyk et al, 2022 ; Szabo et al, 2022 ). In our study, azelaic acid was relatively increased in the DKD-FG group.…”

Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

“…It has been shown that vitamin C is capable of repairing DNA, alleviating oxidative stress, and modulating the activity of telomeres in the aging process, thereby eventually leading to longevity [221]. Vitamin C was generally used as a supplement in cosmetic and dermatologic products for anti-skin-aging purposes [208,[222][223][224]. For instance, a split-face, randomized controlled trial indicated that vitamins C and E improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles of fifty female volunteers aged 30-65 years [225].…”