Clinical Evaluation of Carbocain (Mepivacaine Hci)

SUMMARY 0.5% LAC‐43 (Marcaine®), 2% mepivacaine (Carbocaine®) and 2% prilocaine (Citanest®), all with adrenaline 1:200,000, were compared in extradural anaesthesia in a controlled study. The anaesthesia is illustrated graphically as a surface (segment‐minutes). This makes it possible to compare the results with those of other investigators as regards time of onset, duration and spread of analgesia, regardless of how these have been defined. The duration of analgesia was the only property of those investigated where significant differences between the agents were observed. The duration, defined as the time between the first and last appearance of analgesia, was, on an average, approximately 5 hours for LAC‐43 and 3 hours for mepivacaine and prilocaine. No significant side effects were observed with any of the agents. The results obtained in this investigation are strongly in favour of the use of LAC‐43 whenever a long duration of effect is required.

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A Comparative Study of Lac‐43, Mepivacaine and Tetragaine in Caudal Anaesthesia

Herbring¹

1966

Acta Anaesthesiol Scand

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A long-acting local anaesthetic is desirable in analgesic blocks. Even in operations in which post-operative pain may be expected to be particularly troublesome, e. g. in haemorrhoid operations, anaesthesia with a long-acting local anaesthetic must be considered of invaluable help. Many attempts have been made to produce local anaesthetics with long duration. However, owing to serious side effects, inter alia, irreversible nerve damage, none of the agents previously tested have come into general use. LAC-43 (Marcahem), an agent synthetised at AB Bofors Nobelkrut, Bofors, is a new long-acting local anaesthetic. Chemically, LAC-43 is 1-n-butyl-DL-piperidine-2-carboxylic acid-2,6dimethylanilide hydrochloride and the formula is given in Fig. 1. The toxicity and effect of the drug have been carefully investigated in tests on animals (HENN and BRATTSAND ( 1966)5). Thorough examinations of LAC-43, e.g. intravenous toxicity in man ( JORFELDT et al. (1946)O) and the effect on the conduction velocity in nerves, indicate that this agent does not seem to give rise to any appreciable side effects.Used in controlled clinical investigations, LAC-43 has proved to give a long duration in digital blocks (WIDMAN (1964)15), ulnar blocks (ALBERT and LOFSTROM (1965)1), intercostal blocks (DOTTORI et al. (1964p, TELIWO

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Clinical Evaluation of Carbocain (Mepivacaine Hci)

Cited by 3 publications

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Facial Nerve Block*

Facial Nerve Block*

A Comparison of the Properties of Lag‐43, Prilocaine and Mepivacaine in Extradural Anaesthesia

A Comparative Study of Lac‐43, Mepivacaine and Tetragaine in Caudal Anaesthesia

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