Clinical evaluation of high—molecular-weight sodium hyaluronate for the treatment of patients with periarthritis of the shoulder

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E2 production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

“…29 In clinical practice, however, intraarticular HA injection is well tolerated, and no adverse effects have been reported in most previous studies. [12][13][14][15][30][31][32] Different sets of experiments will be required to confirm our data and verify our working hypothesis.…”

Hyaluronan modulates cell proliferation and mRNA expression of adhesion‐related procollagens and cytokines in glenohumeral synovial/capsular fibroblasts in adhesive capsulitis

“…There is a growing body of evidence supporting the use of HA in patients with adhesive capsulitis of the shoulder, [15][16][17][18] although the mechanisms responsible for the effect have not yet been clarified. Recently, our study has demonstrated that HA inhibits cell proliferation and expression of procollagen a1 (III) mRNA in tendon-derived fibroblasts from patients with rotator cuff disease, suggesting that exogenous HA prevents postoperative adhesion of the repaired rotator cuff tendon.…”

“…Two were men and five were women, with an average age of 55 years (range: 42-65). The average duration of symptoms was 10 months (range: [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. All of the patients had globally restricted range of motion of the shoulder.…”

“…[15][16][17][18] However, the mechanisms responsible for clinical improvement following HA injection are not fully understood.…”

Hyaluronic Acid in the Treatment of Osteoarthritis: What is New

“…In addition, most of the patients experienced an improvement in the shoulder function score and in the activities of daily living (Itokazu & Matsunaga, 1995;Merolla et al, 2011). A recent study comparing Hylan G -F 20 versus 6 methylprednisolone acetate shows that hyaluronic acid is effective in reducing pain for up to 6 months, whereas corticosteroid injections result in improvement at 1 month only (Merolla et al, 2011).…”